Effect of Free and Nanoencapsulated Copaiba Oil on Monocrotaline-induced Pulmonary Arterial Hypertension

Carraro, Cristina Campos; Castro, Alexandre Luz de; Tavares, Ângela Maria Vicente; Fernandes, Rafael Oliveira; Ortiz, Vanessa Duarte; Barboza, Tatiane Evelyn; Pereira, Cláudio; Apel, Miriam Anders; Silva, Onilda Santos da; Llesuy, Susana; Araújo, Alex Sander da Rosa; Belló‐Klein, Adriane

doi:10.1097/fjc.0000000000000442

Cited by 16 publications

(15 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the results reported by other studies with copaiba oil, there are uses of copaiba oil as a vehicle for administration of medicaments, for topical and oral treatment 28,29 , in food technology 30 , dental procedures 30 , and cardiorespiratory processes. 9 Here we can observe a positive result in the use of copaiba oil of 78% according to ►Table 4. This can demonstrate versatility in the use of copaiba oil for different purposes.…”

Section: Resultsmentioning

confidence: 67%

“…8 Likewise, the administration of nanoencapsulated copaiba oil significantly reduced the right ventricular hypertrophy of Wistar rats as well as the oxidative stress. 9 In another study, the administration of copaiba oil by gavage reduced the amount of abdominal adhesions and accelerated the formation of collagen fibers without damaging the early stages of healing. 10 Although a large part of the studies showed positive results with the use of copaiba oil, a small part showed that copaiba oil did not show significant results in the applied objectives.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

View full text Add to dashboard Cite

Recent studies demonstrated that one of the major components of the copaiba oil, β-caryophyllene, has an anti-inflammatory effect. 4 Copaiba oil is extracted from the copaifera, a Abstract Many medicinal plants are sought as alternative therapies for various conditions, as opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of plants with various therapeutic and medicinal properties. One of them is copaiba oil, a natural product of the biodiversity of the Amazon. The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as a great alternative in the treatment of illnesses associated with inflammatory and infectious processes. The purpose of the present study is to evaluate and analyze the latest publications on the use of copaiba oil in the PubMed/Medline database from 2014 to 2017. Forty-two articles were collected, verifying anti-inflammatory activity, antimicrobial activity, healing, and antitumor activity. The results found on researches with copaiba oil according to publication dates were 11.9% in 2014, 38.1% in 2015, 16.7% in 2016, and 33.3% in 2017. In the analyzed studies, the proposed administration of copaiba oil was 50% topical, 28.6% oral, 9.5% enteral, 4.8% subcutaneous, and 7.1% others. In the objectives of the presente study in relation to the administration of copaiba oil, the result was 31% antimicrobial, 28.6% anti-inflammatory, 9.5% antitumor, 9.5% healing, and 21% others. Regarding the types of research, we have found 50% in vitro, 40.4% in vivo animals, 2.4% in vivo human, 2.4% review and 4.8% others. Regarding the significance factor evaluation, the result was 100% positive in antitumor activity, 84% positive in infection and inflammation pathology, 62% positive in others, like dental processes, food technology application support and as a drug absorption vehicle, and 50% in healing. The results presented in the current meta-analysis show that copaiba oil is an effective alternative to treatments of illnesses such as chronic inflammation, infectious diseases, various types of cancer, autoimmune diseases, and as a vehicle for the absorption of other drugs. Thus, more studies regarding the benefits of copaiba oil could provide a great contribution to the medical community in the treatment of the aforementioned illnesses.

show abstract

Section: Resultsmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 98%

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Thus, the authors concluded that nanoformulation is more effective on heart tissue than pulmonary circulation. Moreover, the preparation of nanocapsules using pectin aqueous solution with antioxidant effect could have a synergistic effect with copaiba oil and increased pharmacological effect (Campos et al, 2017). Therefore, nanoencapsulation has been known effective in favorable delivery and better efficiency of copaiba oil.…”

Section: Pulmonary Arterial Hypertensionmentioning

confidence: 99%

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nouri

Hajialyani

Izadi

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Metabolic syndrome includes a series of metabolic abnormalities that leads to diabetes mellitus and cardiovascular diseases. Plant extracts, due to their unique advantages like anti-inflammatory, antioxidant, and insulin sensitizing properties, are interesting therapeutic options to manage MetS; however, the poor solubility and low bioavailability of lipophilic bioactive components in the herbal extracts are two critical challenges. Nano-scale delivery systems are suitable to improve delivery of herbal extracts. This review, for the first time, focuses on nanoformulations of herbal extracts in MetS and related complications. Included studies showed that several forms of nano drug delivery systems such as nanoemulsions, solid lipid nanoparticles, nanobiocomposites, and green-synthesized silver, gold, and zinc oxide nanoparticles have been developed using herbal extracts. It was shown that the method of preparation and related parameters such as temperature and type of polymer are important factors affecting physicochemical stability and therapeutic activity of the final product. Many of these formulations could successfully decrease the lipid profile, inflammation, oxidative damage, and insulin resistance in in vitro and in vivo models of MetS-related complications. Further studies are still needed to confirm the safety and efficacy of these novel herbal formulations for clinical application.

show abstract

“…BCP is one of the most important components of Copaiba oil, popularly used in Brazil for respiratory and cardiovascular illnesses. The nanocapsules of copaiba oil were shown to attenuate monocrotalineinduced pulmonary arterial hypertension in rats by counteracting the oxidative stress and inflammation, and by improving the cardiac function (Campos et al, 2017). One of the major clinical features and reasons for death in COVID-19 patients is respiratory distress syndrome, that also leads to acute cardiac injury .…”

Section: Bcp May Be Prospective In Covid-19 Associated Cardiovascular Conditionsmentioning

confidence: 99%

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

et al. 2021

View full text Add to dashboard Cite

Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite tremendous social preventive measures. Identifying candidate drugs for the prevention and treatment of COVID-19 is crucial. The pathogenesis and the complications with advanced infection mainly involve an immune-inflammatory cascade. Therefore, therapeutic strategy relies on suppressing infectivity and inflammation, along with immune modulation. One of the most promising therapeutic targets for the modulation of immune-inflammatory responses is the endocannabinoid system, particularly the activation of cannabinoid type 2 receptors (CB2R), a G-protein coupled receptor which mediates the anti-inflammatory properties by modulating numerous signaling pathways. To pharmacologically activate the CB2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (BCP), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. BCP is recognized as a full selective functional agonist on CB2 receptors and produces therapeutic effects by activating CB2 and the nuclear receptors, peroxisome proliferator-activated receptors (PPARs). BCP is regarded as the first dietary cannabinoid with abundant presence across cannabis and non-cannabis plants, including spices and other edible plants. BCP showed tissue protective properties and favorably modulates numerous signaling pathways and inhibits inflammatory mediators, including cytokines, chemokines, adhesion molecules, prostanoids, and eicosanoids. Based on its pharmacological properties, molecular mechanisms, and the therapeutic potential of BCP as an immunomodulator, anti-inflammatory, organ-protective, and antiviral, we hypothesize that BCP could be a promising therapeutic and/or preventive candidate to target the triad of infection, immunity, and inflammation in COVID-19. In line with numerous studies that proposed the potential of cannabinoids in COVID-19, BCP may be a novel candidate compound for pharmaceutical and nutraceutical development due to its unique functional receptor selectivity, wide availability and accessibility, dietary bioavailability, nonpsychoactivity, and negligible toxicity along with druggable properties, including favorable pharmacokinetic and physicochemical properties. Based on reasonable pharmacological mechanisms and therapeutic properties, we speculate that BCP has potential to be investigated against COVID-19 and will inspire further preclinical and clinical studies.

show abstract

Effect of Free and Nanoencapsulated Copaiba Oil on Monocrotaline-induced Pulmonary Arterial Hypertension

Cited by 16 publications

References 54 publications

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

Contact Info

Product

Resources

About