Effect of gala apples (Malus domestica Borkh) on lipidemia of hyperlipidemic rats

Salgado, Jocelem Mastrodi; Curte, Fabiana; Mansi, Débora Niero

doi:10.1590/s0101-20612008000200032

Cited by 12 publications

(7 citation statements)

References 35 publications

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“…This appeared to have been through the mechanism of the fruit that lowers overall blood cholesterol level and inflammation [13]. Significantly reduced plasma cholesterol, LDL cholesterol (LDL-C) and triglyceride concentrations resulted on several animal and human apple consumption trials [21][22][23][24].…”

Section: Page 4 Of 11mentioning

confidence: 99%

Biologically Active Triterpenoids and Their Cardioprotective and Anti- Inflammatory Effects

Bakovic¹

2015

J Bioanal Biomed

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Section: Page 4 Of 11mentioning

confidence: 99%

Biologically Active Triterpenoids and Their Cardioprotective and Anti- Inflammatory Effects

Bakovic¹

2015

J Bioanal Biomed

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“…Em estudo, utilizando ratos alimentados com dietas acrescidas de banha de porco e diferentes doses de resíduo do abacaxizeiro, Piedade & Canniati-Brazaca (2003) observaram, após 45 dias de tratamento, redução em torno de 21,5% na concentração de CT dos animais que receberam 25% de resíduo. A administração de dieta hipercolesterolêmica adicionada de 25% de maçã gala demonstrou redução de 20,7% da concentração de CT em ratos, após 30 dias de tratamento (Salgado et al, 2008). Comparandose os resultados aqui apresentados com os da literatura, é possível verificar que a redução da concentração de CT obtida com a administração de farinha de cubiu por 14 dias é semelhante, e às vezes superior às obtidas com administração de outros frutos por período de tratamento superiores, indicando que com a administração do cubiu, os resultados são obtidos mais rapidamente.…”

Section: Gruposunclassified

Efeito hipolipemiante da suplementação dietética com a farinha do cubiu (Solanum sessiliflorum Dunal) em ratos hipercolesterolêmicos

Maia

Schwertz

Sousa

et al. 2015

Rev. bras. plantas med.

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RESUMO:Estudos com frutas e vegetais ricos em fibra alimentar tem demonstrado efeito redutor das concentrações sanguíneas de colesterol total, atuando de forma preventiva contra a hipercolesterolemia. O objetivo do presente trabalho foi analisar a composição química da farinha de cubiu e avaliar o efeito de seu consumo sobre a lipemia de ratos hipercolesterolêmicos. Foram utilizados 8 animais para cada tratamento, em 7 grupos sendo: 1 controle; 3 experimentais com 5%, 25% e 50% da recomendação de fibras (AIN-93) provenientes da farinha de cubiu; e 3 grupos per feeding tendo celulose e pectina como fonte de fibra alimentar nas mesmas proporções dos grupos experimentais. Ao final do ensaio foi verificado que não houve variação significativa no consumo de ração pelos animais e no ganho de massa corporal no decorrer do experimento. Os tratamentos com farinha de cubiu reduziram as concentrações de colesterol total (-21,6%), LDL-c (-56,8%), aumentaram a excreção de colesterol fecal (+116%), e diminuíram o colesterol hepático (-32,1%). Nenhum dos tratamentos promoveu alteração significativa nas concentrações de triglicerídeos. Os tratamentos com pectina e celulose demonstraram resultados semelhantes aos do cubiu. Os resultados observados servem como base para futuros estudos visando o aproveitamento biotecnológico deste fruto. Palavras-chave:Solanum sessiliflorum Dunal, cubiu, fibra alimentar, hipercolesterolemia.ABSTRACT: Hypolipidemic effect of diet supplementation with cocona (Solanum sessiliflorum Dunal) flour in hypercholesterolemic rats. Studies with fruit and vegetables rich in dietary fiber have shown lowering effects on the blood concentrations of total cholesterol (TC), acting preventively against hypercholesterolemia. The aim of this study was to analyze the chemical composition of cocona and evaluate the effect of the consumption of cocona flour on lipemia of Wistar rats with hypercholesterolemia. Eight animals were used for each treatment, in 7 groups: control; 3 experimental groups with 5%, 25% and 50% of the recommended fiber (AIN-93) from cocona flour; 3 groups per feeding with pectin and cellulose as source of dietary fiber, in the same proportions of the experimental groups. At the end of the assay, we verified that there were not significant variations in the consumption of the animals and the body weight during the experiment. Treatments with cocna flour were responsible for reducing the concentrations of total cholesterol (-21.6%), LDL-c (-56.8%), increasing the excretion of fecal cholesterol (+116%) and lowering the liver cholesterol (-32.1%). None of the treatments significantly altered the triglyceride concentrations. Treatments using pectin and cellulose show results similar to cocona. The observed results can be used in further studies aimed at the biotechnological exploitation of this fruit.

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“…peroxisome proliferatorsactivated receptor on a high-fat diet were treated with aqueous celery extract (Apium graveolens) or gala apples (Malus domestica Borkh), reductions were observed in total serum cholesterol, LDL levels, and triglyceride levels [6,7]. In addition, some spices were reported to have hypocholesterolemic properties, including fenugreek (Trigonella foenum graecum), ginger (Zingiber officinale), onion (Allium cepa), turmeric (Curcuma longa), coriander (Coriandrum sativum), caraway (Carum carvi), black pepper (Piper nigrum), and chili pepper (Capsicum frutescens) [8][9][10][11][12].…”

Section: Hdlmentioning

confidence: 99%

PPARαActivation by Culinary Herbs and Spices

2010

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Hyper- and dyslipidemia are risk factors for cardiovascular disease, the primary cause of death in industrialized countries. Peroxisome proliferators-activated receptor (PPAR)α activation is involved in various mechanisms that improve the lipid profile. We tested various plant extracts and their compounds to determine whether they stimulated PPARα activity in vitro. Out of 34 tested plant extracts, nine exhibited low to moderate PPARα transactivation, including caraway, chili pepper, nutmeg, licorice, black and white pepper, paprika, coriander, saffron, and stevia tea. The active components of black pepper and chili pepper, piperine, and capsaicin exerted the highest transactivational activities with EC₅₀ values of 84 µM and 49 µM, respectively. The chalcones, including 2-hydroxychalcone, 2'-hydroxychalcone, 4-hydroxychalcone, and 4-methoxychalcone, moderately transactivated PPARα. Resveratrol and apigenin only slightly transactivated PPARα. These results suggest that a diet rich in fruit, herbs, and spices provides a number of PPARα agonists that might contribute to an improved lipid profile.

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Effect of gala apples (Malus domestica Borkh) on lipidemia of hyperlipidemic rats

Cited by 12 publications

References 35 publications

Biologically Active Triterpenoids and Their Cardioprotective and Anti- Inflammatory Effects

Biologically Active Triterpenoids and Their Cardioprotective and Anti- Inflammatory Effects

Efeito hipolipemiante da suplementação dietética com a farinha do cubiu (Solanum sessiliflorum Dunal) em ratos hipercolesterolêmicos

PPARαActivation by Culinary Herbs and Spices

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