Effect of garlic oil on ethanol induced gastric ulcers in rats

Khosla, Pamela; Karan, Rajesh; Bhargava, V.K.

doi:10.1002/ptr.1349

Cited by 26 publications

(19 citation statements)

References 19 publications

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“…Animals of the third group were given a single nicorandil (Torrent Pharmaceuticals, India) dose (10 mg/kg), intraperitoneally [25], 30 min before a single indomethacin dose as in group two. The fourth group animals were given a single oral ethanol 100% (Prolabo) dose as 1 ml/100 g [19]. The fifth group animals were given a single nicorandil dose, 30 min before a single ethanol dose.…”

Section: Methodsmentioning

confidence: 99%

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Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

El‐Moselhy

Abdel-Hamid

Abdelraheim

2008

Appl Biochem Biotechnol

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Despite the fact that dietary habits and lifestyles are incredibly advancing, gastric ulceration is still a terrible complaint. Extensive use of non-steroidal anti-inflammatory drugs (NSAIDs) and alcohol, in addition to stress, are all predisposing factors for ulcers. Most medical treatments are always time consuming and not efficient or satisfactory to the patients. Cardiovascular patients always need NSAIDs, or mostly cannot quit alcohols, while using many cardiovascular drugs. We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil [N-(2-hydroxyethyl) nicotinamide nitrate ester], in managing acute gastric ulcers through studying its effect on some relevant intermediates to ulcerogenesis as lipid peroxidation, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO). In addition, gastric mucosal histology was studied to pursue the drug effects on tissue level. Our study revealed that both indomethacin and alcohol induced gastric ulcer mainly through up-regulation of gastric mucosal lipid peroxidation, local tissue inflammation, leukocytic infiltration, and necrosis. Both ulcerogens significantly elevated TNF-alpha and decreased NO, initiating ulcer formation. Nicorandil pretreatment depicted a higher preventive index in indomethacin- (89.8%) and alcohol-induced (77.7%) acute ulceration. On the tissue level, it also protected the gastric mucosa combating leukocyte infiltration and tissue congestion. Nicorandil protected tissue necrosis through decreasing oxidative stress, elevating NO levels, and down-regulating the ulcerogen-induced TNF-alpha elevation and improved sub-mucosal blood supply. We conclude that nicorandil may be a suitable bimodal treatment for cardiovascular patients who are at high risk of gastric ulcers by using variable analgesics to alleviate possible cardiac pain episodes, and probably frequent doses will offer a more established and long-lasting protection.

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Section: Methodsmentioning

confidence: 99%

“…It causes mucosal cellular injury through activation of matrix metalloproteinase enzymes, TNF-α release, lipid peroxidation, and protein carbonyl formation [18]. Thus, ethanol was frequently used as an experimental inducer of acute gastric ulcers [19].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

El‐Moselhy

Abdel-Hamid

Abdelraheim

2008

Appl Biochem Biotechnol

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“…In a recent study preteatment of ethanol-induced gastic ulcer with garlic oil reduced the ulcer index and LPO and ameliorated the decrease in levels of antioxidant enzymes such as GPX, CAT, and SOD [43]. Aged garlic extract and diallyl polysulfides inhibit the formation of thiobarbituric acidreactive and fluorescent substances induced by iron-ascorbic acid in isolated liver microsomal membranes, indicating the protective effect of garlic against lipid peroxidation [44].…”

Section: Discussionmentioning

confidence: 97%

Protective Effects of Aqueous Garlic Extract in Reducing Water Avoidance Stress-Induced Degeneration of the Stomach, Ileum, and Liver: Morphological and Biochemical Study

Zeybek¹,

Ercan

Çetınel

et al. 2007

Dig Dis Sci

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We investigated the effect of aqueous garlic extract (AGE) on water avoidance stress (WAS)-induced degeneration of the gastric and ileal mucosa and liver parenchyma. Wistar albino rats were exposed to WAS (WAS group) for 5 days. After exposure of the animals to WAS, a 1 ml/kg aqueous garlic extract (AGE) was injected i.p. (WAS+AGE group). The stomach, ileum, and liver samples were investigated under light microscope for general morphology. Topography of gastric and ileal mucosa was investigated by scanning electron microscopy, and hepatocyte ultastructure by transmission electron micsroscopy. Malondialdehyde (MDA) and glutathione (GSH) levels of all tissues were also determined. In the WAS group, the epithelium of the stomach showed ulceration in some areas, dilatations of the gastric glands, and degeneration of gastric glandular cells. Severe vascular congestion and degeneration of ileal epithelium were observed. Prominent vascular congestion and dilated sinusoids, activated Kupffer cells with prominent morphology, dilated granular endoplasmic reticulum membranes, and focal picnotic nuclei were observed in liver parenchyma. AGE treatment reduced the degeneration of the gastric and ileal mucosa and liver parenchyma. Increased MDA levels and decreased GSH levels in the WAS group were reversed to control values after AGE treatment. Based on these results, AGE treatment significantly prevented WAS-induced degeneration in both morphology and biochemistry of gastrointestinal mucosa and liver parenchyma due to its potent free radical scavenging and antioxidant properties.

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“…Gastric ulcers are also associated with increased lipid peroxidation [47][48][49][50][51][52]. It has been demonstrated that many pathologic conditions that caused elevation of MDA due to lipid peroxidation were prevented by carnitine and its derivatives, including ischemia/reperfusion injury [53][54][55], drug-induced cardiomyopathy [56][57][58], and myocardial infarction [59,60].…”

Section: Discussionmentioning

confidence: 99%

The role of L-carnitine in acetyl salicylic acid-induced acute gastric mucosal injury in rats

Uz¹,

Türkay²,

Uyar³

et al. 2017

Arch Med Sci Civil Dis

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A b s t r a c tIntroduction: The aim of this study was to determine the protective effects of L-carnitine on acetyl salicylic acid (ASA)-induced acute gastric mucosal injury through oxidant/antioxidant parameters and histopathological alterations in rat gastric tissues. Material and methods: Forty-two rats were randomly assigned to six groups: The control group received 1 mg/kg distilled water, while the other groups were pretreated with L-carnitine 50 mg/kg/day (LC), pantoprazole 40 mg/ kg/day (PPI), ASA + LC (50 mg/kg/day), and ASA + PPI (40 mg/kg/day), for 21 days, respectively. On day 23, gastric mucosal injury was induced by a single intragastric administration of 600 mg/kg aspirin in ASA, ASA + LC, and ASA + PPI groups. The animals were killed 60 min after the administration of aspirin. The stomach of each animal was removed. Gastric mucosal injury was scored histopathologically (ulcer score). Tissue catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) and nitric oxide (NO) levels were also measured. Results: The ulcer score increased significantly in the ASA group, but this increase was not significantly inhibited by the administration of L-carnitine (2.71 ±1.0 vs. 2.57 ±0.5, p = 0.965). The CAT and GSH-Px activities were significantly reduced, whereas MDA and NO levels were significantly increased in the ASA group. Pretreatment with L-carnitine did not alter CAT or GSH-Px activities, but reduced MDA and NO levels insignificantly (p = 0.204 and p = 0.277, respectively). Conclusions: Long-term administration of L-carnitine did not improve the oxidative and histological parameters of acute gastric mucosal injury induced by ASA.

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Effect of garlic oil on ethanol induced gastric ulcers in rats

Cited by 26 publications

References 19 publications

Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

Protective Effects of Aqueous Garlic Extract in Reducing Water Avoidance Stress-Induced Degeneration of the Stomach, Ileum, and Liver: Morphological and Biochemical Study

The role of L-carnitine in acetyl salicylic acid-induced acute gastric mucosal injury in rats

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