Exclusive breastfeeding led to decreasing 40 percent of children under-five mortality in Indonesia. Exclusive breastfeeding rate found in Cilacap in 2014 around 36,16 percent. Midwife role was able to increase exclusive breastfeeding. This research aim was to analyze midwife role on exclusive breastfeeding in Cilacap. Type of this study was a correlation descriptive with cross-sectional approach. Of 220 mothers who had babies aged 6-12 month in Puskesmas Cilacap Selatan I in 2014 collected by a cluster random sampling method. The analysis data used the chi-square test. The results showed a strong effect between breast care (OR=6,35; Cl 95 percent=3,27-12,31; p=0.000) and the initiation of breastfeeding (OR=11,56; Cl 95 percent=4,04-33,07; p=0.000) on exclusive breastfeeding. While exclusive breastfeeding promotion (OR= 1,55; Cl 95 percent=0,69-3,47; p=0,279) was sufficiently influential on exclusive breastfeeding. Midwife role on promotion of exclusive breastfeeding, beast care, and initiation breastfeeding affected the exclusive breastfeeding