Effect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed rats

Tümer, Cemıl; Bilgin, Hakkı Murat; Obay, Basra Deniz; Diken, Hüda; Taşdemir, Ezel; Şermet, Abdurrahman

doi:10.1016/j.regpep.2006.08.010

Cited by 17 publications

(9 citation statements)

References 33 publications

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“…It was also shown that ghrelin increased mRNA levels of superoxide dismutase and GH in leukocytes, suggesting that the effects of ghrelin was mediated, at least in part, by stimulating GH secretion from leukocytes. On the other hand, ghrelin administration reportedly reduced the elevated phagocytic activity of peritoneal macrophages induced by acute cold-restraint stress in rats [158]. These results may indicate that ghrelin modulates phagocytosis directly or indirectly via GH, but in a different way in different species.…”

Section: Modulation Of Phagocytosismentioning

confidence: 81%

Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

Hattori

2009

Growth Hormone & IGF Research

186

139

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Section: Modulation Of Phagocytosismentioning

confidence: 81%

Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

Hattori

2009

Growth Hormone & IGF Research

186

139

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“…Biological action of ghrelin on the immune system includes attenuation of septic shock, promotion of thymopoiesis during aging in mice and inhibition of expression of pro-inflammatory cytokines by human monocytes and T lymphocytes [61–64]. Moreover, administration of ghrelin reduces phagocytic activity of peritoneal macrophages in rats exposed to cold-restraint stress [65]. …”

Section: Discussionmentioning

confidence: 99%

Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats

et al. 2012

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SummaryBackgroundPrevious studies have shown that administration of ghrelin exhibits protective and therapeutic effects in the gut. The aim of the present investigation was to examine the influence of ghrelin administration on the course of cysteamine-induced duodenal ulcers, as well as effects on mucosal production of oxygen free radicals and duodenal antioxidant defense.Material/MethodsDuodenal ulcers were induced in male Wistar rats by cysteamine administered intragastrically at the dose of 200 mg/kg in 1 ml of saline, 3 times at 4-h intervals. Starting 24 h after the first dose of cysteamine, rats were treated intraperitoneally twice a day with saline or ghrelin given at the dose of 4, 8 or 16 nmol/kg/dose. Seven days after administration of the first dose of cysteamine, the study was terminated.ResultsInduction of ulcers by cysteamine was accompanied by a reduction in duodenal blood flow, mucosal DNA synthesis and mucosal activity of superoxide dismutase (SOD); whereas mucosal concentration of interleukin-1β and malonyldialdehyde (MDA – an index of lipid peroxidation) were increased. Treatment with ghrelin increased healing rate of duodenal ulcers and enhanced duodenal blood flow, mucosal DNA synthesis and mucosal activity of SOD, and reduced mucosal concentration of interleukin-1β and MDA.ConclusionsTreatment with ghrelin increases the healing rate of duodenal ulcers and this effect is related, at least in part, to improvement of duodenal mucosal blood flow, mucosal cell proliferation and antioxidant defense, as well as being related to reduction in mucosal oxidative stress and inflammatory response.

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“…VIP, PACAP, UCN and CST also downregulate the expression of other inflammatory mediators, such as inducible nitric oxide synthase and cyclooxygenase 2 (COX2), and the subsequent release of nitric oxide and prostaglandin E2 by macrophages, dendritic cells (DCs) and microglia [58,59,60,61]. Specifically, VIP and GHR regulate the activation of peritoneal macrophages, by inhibiting their phagocytic activity, and modulate free radical production, adherence and migration [62,63]. In the same way, VIP and UCN induce apoptosis of macrophages under inflammatory conditions which affects its subsequent activation [62,64].…”

Section: Endogenous Anti-inflammatory Neuropeptides With An Immunomodmentioning

confidence: 99%

Neuropeptides as Pleiotropic Modulators of the Immune Response

et al. 2011

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Although necessary to eliminate pathogens, inflammation can lead to serious deleterious effects in the host if left unchecked. During the inflammatory response, further damage may arise from potential autoimmune responses occurring when the immune cells and molecules that respond to pathogen-derived antigens also react to self-antigens. In this sense, the identification of endogenous factors that control exacerbated immune responses is a key goal for the development of new therapeutic approaches for inflammatory and autoimmune diseases. Some neuropeptides that are produced during the ongoing inflammatory response have emerged as endogenous anti-inflammatory agents that could collaborate in tuning the balanced steady state of the immune system. These neuropeptides participate in maintaining immune tolerance through two distinct mechanisms: by regulating the balance between pro-inflammatory and anti-inflammatory factors, and by inducing the emergence of regulatory T cells with suppressive activity against autoreactive T cell effectors. Indeed, a functioning neuropeptide system contributes to general health, and alterations in the levels of these neuropeptides and/or their receptors lead to changes in susceptibility to inflammatory and autoimmune diseases. Recently, we found that some neuropeptides also have antimicrobial and antiparasitic actions, suggesting that they could act as primary mediators of innate defense, even in the most primitive organisms. In this review, we use the vasoactive intestinal peptide as example of an immunomodulatory neuropeptide to summarize the most relevant data found for other neuropeptides with similar characteristics, including adrenomedullin, urocortin, cortistatin and ghrelin.

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Effect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed rats

Cited by 17 publications

References 33 publications

Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats

Neuropeptides as Pleiotropic Modulators of the Immune Response

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