Effect of Ginseng and Herbal Plant Mixtures on Anti-Obesity in Obese SD Rat Induced by High Fat Diet

Abstract

Anti-obesity effects of ginseng and herbal plant mixtures were investigated to develop natural materials for anti-obesity. After inducing obesity with high fat diet for 8 weeks in male SD rats, ginseng and herbal plant mixtures DM1 (ginseng, puer tea, opuntia) and DM2 (ginseng, puer tea) were administrated orally to rats for another 8 weeks. During administration, food efficacy ratio and body weight of rat were measured twice weekly. After administration, body weight, body fat contents, and serum lipid level were estimated for anti-obesity effect and hematological analysis blood level of ALP and ASP was checked for safety. Body weight in rats fed high fat diet was significantly increased. Body weight in obese rats induced by high fat diet was significantly decreased by DM1 and DM2 feedings. The amount of body fat (epididymal, perirenal and visceral fat, brown adipose tissue) was significantly reduced by DM1 and DM2 treatments. The amount of TG, the concentration of leptin in blood plasma, and the concentration of insulin in blood plasma were significantly diminished by DM1 and DM2. Lipid accumulation on liver was reduced in DM2. There were no side effects among all groups according to blood analysis, hematological findings, and body weight. The findings of this study suggest that DM1 and DM2 may be effective materials for anti-obesity through reducing plasma triglyceride and body fats, and also decreasing body weight without side effects.

Effects of the Red Garlic Extract for Anti-Obesity and Hypolipidemic in Obese Rats Induced High Fat Diet

“…These result are similar to a reports that obese rats induced high fat diet takes in food at lower degree than a normal group, but the FER was higher [37,49], and which is reported to stem from the high calories by high fat [37]. Rats are considered obese when T.M.…”

Effects of Exhaustive Exercise and Aged Garlic Extract Supplementation on Weight, Adipose Tissue Mass, Lipid Profiles and Oxidative Stress in High Fat Diet Induced Obese Rats

“…천연물을 활용한 항비만 소재 개발에 관한 결과를 살펴보면 작용기전에 따라 지방의 소화 및 흡수를 저해하는 물질로서 키토산, 플라보노이드 등이 있으며 [56], 열 발생을 유도하여 지방 축적을 억제하는 물질로서 고추의 캡사이신, 녹차의 카 테친, 레티노익산 등이 있다 [18]. 그리고 지질대사를 조절하는 카르니틴이 있으며, 생약재로는 지실, 결명자, 소나무잎, 천궁 등이 체중조절에 효과가 있다는 결과가 보고되었다 [36].…”

Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis

“…This showed antiinflammatory and antisteatotic effects in the NASH model. Recently, various studies have been striving to develop a complex treatment by mixing ingredients known to have disease-relieving effects [ [15] , [16] , [17] , [18] ]. These attempts may address the limited supply of existing ingredients and lead to the development of new health functional foods.…”

“…Previous studies have suggested that a mixture of KRG and other botanical therapeutic ingredients such as coffee, puer tea, buckwheat or licorice ( Glycyrrhiza uralensis Fischer) have complex enhancement effects on various indices related to antioxidative, antibacterial, antiobesity, or collagenase inhibitory activity [ [15] , [16] , [17] , [18] ]. Among them, glycyrrhizin, a constituent of licorice, has a sweet taste and is known to have antiobesity effects and to alleviate allergy asthma [ 17 , 19 ].…”