Effect of glycemic control on vitamin B12 metabolism in diabetes mellitus

Takahashi, Yoshiastu; Takayama, Shinichirou; Itou, Takeshi; Owada, Kazuhiro; Omori, Yasue

doi:10.1016/0168-8227(94)90156-2

Cited by 12 publications

(7 citation statements)

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“…However, vitamin B 12 and folate supplementation has been shown to reduce homocsyteine concentrations and improve cardiovascular outcomes such as reducing the rate of coronary restenosis after percutaneous coronary intervention [43]. The correlation of vitamin B 12 with HbA 1 and 2-h plasma glucose has not been reported previously, though higher vitamin B 12 concentrations have been found in subjects with diabetes than in those with normal glucose tolerance, and concentrations decreased when glycemic control improved [44]. In contrast to vitamin B 12 , the association between folate and HbA 1 was negative and elevated folate was only associated with mortality in models that included HbA 1 .…”

Section: Discussionmentioning

confidence: 91%

Homocysteine and vitamin B₁₂ concentrations and mortality rates in type 2 diabetes

Looker

Fagot-Campagna

Gunter

et al. 2007

Diabetes Metabolism Res

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Over a median follow-up of 15.7 years, there were 221 deaths-76 were due to cardiovascular disease (CVD), 36 to diabetes/nephropathy and 34 to infections. Homocysteine was positively associated with mortality from all causes (hazard rate ratio (HRR) for highest versus lowest tertile of homocysteine = 1.70, 95% confidence interval (CI) 1.18-2.46), from diabetes/nephropathy (HRR = 2.39, 95% CI 0.94-6.11) and from infectious diseases (HRR = 3.39, 95% CI 1.19-9.70), but not from CVD (HRR = 1.16, 95% CI 0.62-2.17) after adjustment for age, sex and diabetes duration. Homocysteine correlated with serum creatinine (r = 0.50), and the relationships with mortality rates were not significant after adjustment for creatinine. Vitamin B(12) was positively associated with all-cause mortality (HRR for 100 pg/mL difference adjusted for age, sex and diabetes duration = 1.15, 95% CI 1.08-1.22) and death from diabetes/nephropathy (HRR = 1.27, 95% CI 1.10-1.46). The association between homocysteine and mortality in type 2 diabetes is not causal, but is confounded by renal disease in Pima Indians.

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Section: Discussionmentioning

confidence: 91%

Homocysteine and vitamin B₁₂ concentrations and mortality rates in type 2 diabetes

Looker

Fagot-Campagna

Gunter

et al. 2007

Diabetes Metabolism Res

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“…22) The transcobalamin 2 protein binds vitamin B12 and diabetic patients have a higher total B12 binding capacity and higher serum B12 levels. 23) Thus, these genes are potential markers for judging the onset and progression of diabetes.…”

Section: Discussionmentioning

confidence: 99%

DNA Microarray Analysis of Type 2 Diabetes-Related Genes Co-regulated between White Blood Cells and Livers of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

Hayashi

Iida

Sato

et al. 2007

Biological & Pharmaceutical Bulletin

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In a previous study, we hypothesized that some type 2 diabetes mellitus susceptible genes may be up/downregulated in white blood cells (WBC) of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, reflecting their up/down-regulation in major insulin-target tissues such as the liver before the onset of diabetes. We identified 57 potential candidate genes for predicting diabetes. In this study, we examined this hypothesis further by extending the experimental conditions from before the onset (6 weeks) to after the onset (24 weeks) of diabetes that type 2 diabetes mellitus susceptible genes are co-regulated in WBC, reflecting their expression in the liver. Using rat oligo DNA microarrays, we found that 48 genes are up/down-regulated in OLETF rats compared to control Long-Evans Tokushima Otsuka (LETO) rats in WBC and liver under fasting or insulin administration conditions. Twenty nine and 33 genes were up/down-regulated in both WBC and livers, respectively, under fasting and insulin administration conditions, respectively. Eight out of 29 genes in fasting condition and 12 out of 33 genes in insulin administration conditions have been reported to be type 2 diabetes mellitus susceptible genes and the remainder have not been reported to be related to type 2 diabetes mellitus. These results support our hypothesis that the expression levels of type 2 diabetes mellitus related genes in WBC are reflective of those in the liver after the onset of diabetes.

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“… 17 In fact, serum TCB may undergo glycosylation in diabetic patients, with consequently increased serum vitamin B12 levels. 8 In addition, vitamin B12 is ‘trapped’ in the plasma in patients with hyperglycemia, which leads to increased serum vitamin B12 levels, which explains the positive correlation with higher serum glycated hemoglobin levels. 18 , 19 Our results showed a positive correlation between serum vitamin B12 levels and glycated hemoglobin in T2DM patients who did not receive metformin therapy, which is consistent with the findings reported by the aforementioned studies.…”

Section: Discussionmentioning

confidence: 99%

“… 6 A recent study also reported that add-on supplementation with vitamin B12 can improve glycemic control and insulin resistance in T2DM patients. 7 Reportedly, patients with diabetes have higher serum vitamin B12 levels than those with normal glycemic control, and fructosamine levels are significantly correlated with serum vitamin B12 levels in patients with DM, 8 which suggests that serum vitamin B12 levels may be associated with glycemic control in T2DM. However, no study has investigated the correlation between serum vitamin B12 levels and glycemic fluctuation in patients with T2DM.…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus

Zhao

Zhu

et al. 2022

Therapeutic Advances in Endocrinology

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Purpose: The aim of the study was to explore the correlation between serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus (T2DM). Methods: This study included 202 T2DM patients in whom blood glucose levels were recorded using a continuous glucose monitoring system retrospectively. Glycemic fluctuation was determined using the average daily risk range (ADRR), a diabetes-specific measure of the risk for hyper- and hypoglycemia. Results: Serum vitamin B12 levels were higher in T2DM patients with wider glycemic fluctuations than in those with minor glycemic fluctuations ( p < 0.001). We observed a positive correlation between serum vitamin B12 levels and ADRR in both T2DM patients who received and did not receive metformin therapy ( r = 0.388, p < 0.001 and r = 0.280, p = 0.004, respectively). Multiple linear regression analysis showed that serum vitamin B12 levels were independently correlated with ADRR in T2DM patients who received and did not receive metformin therapy (beta = 0.367, p < 0.001 and beta = 0.410, p < 0.001, respectively). Conclusions: Serum vitamin B12 levels are correlated with glycemic fluctuation in patients with T2DM and may serve as an underlying useful biomarker of glycemic fluctuation in T2DM patients, treated with or without metformin therapy.

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Effect of glycemic control on vitamin B12 metabolism in diabetes mellitus

Cited by 12 publications

References 1 publication

Homocysteine and vitamin B₁₂ concentrations and mortality rates in type 2 diabetes

Homocysteine and vitamin B₁₂ concentrations and mortality rates in type 2 diabetes

DNA Microarray Analysis of Type 2 Diabetes-Related Genes Co-regulated between White Blood Cells and Livers of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

Serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus

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Effect of glycemic control on vitamin B12 metabolism in diabetes mellitus

Cited by 12 publications

References 1 publication

Homocysteine and vitamin B12 concentrations and mortality rates in type 2 diabetes

Homocysteine and vitamin B12 concentrations and mortality rates in type 2 diabetes

DNA Microarray Analysis of Type 2 Diabetes-Related Genes Co-regulated between White Blood Cells and Livers of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

Serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus

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Homocysteine and vitamin B₁₂ concentrations and mortality rates in type 2 diabetes

Homocysteine and vitamin B₁₂ concentrations and mortality rates in type 2 diabetes