Effect of Grape Procyanidins on Tumor Angiogenesis in Liver Cancer Xenograft Models

Li, Feng; Liu, Bingxia; Zhong, Jian; Sun, Lili; Yu, Hongsheng

doi:10.7314/apjcp.2014.15.2.737

Cited by 30 publications

(14 citation statements)

References 29 publications

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“…The degree of polymerization and galloylation affects their bioactivity and proanthocyanidin profiles differently depending on the food sources (Akagi et al, 2011;Praphasawat et al, 2011;Feng et al, 2014). Our results showed that proanthocyanidin was detected only in the CEE fraction, but not in the Hex and DCM fractions.…”

Section: Discussionsupporting

confidence: 51%

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Pintha

Yodkeeree²,

Pitchakarn³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 51%

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Pintha

Yodkeeree²,

Pitchakarn³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Liver cancer is enriched with blood vessels, and angiogenesis plays a key role in cancer metastasis and relapse. The treatment of grape procyanidin in a liver cancer xenograft model exerted anti-angiogenic activity in a dose dependent manner by suppressing proliferation of vascular endothelial cells [ 19 ]. Researchers also suggested a possible anti-carcinogenic use against HCC for grape seed extracts from winery waste.…”

Section: Fruitsmentioning

confidence: 99%

Dietary Natural Products for Prevention and Treatment of Liver Cancer

et al. 2016

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Liver cancer is the most common malignancy of the digestive system with high death rate. Accumulating evidences suggests that many dietary natural products are potential sources for prevention and treatment of liver cancer, such as grapes, black currant, plum, pomegranate, cruciferous vegetables, French beans, tomatoes, asparagus, garlic, turmeric, ginger, soy, rice bran, and some edible macro-fungi. These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs. This review summarizes the potential prevention and treatment activities of dietary natural products and their major bioactive constituents on liver cancer, and discusses possible mechanisms of action.

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“…Procyanidins not only inhibits the growth of various cancer cells such as digestive system neoplasms, respiratory tumors, urogenital neoplasms (Feng et al 2014, Li et al 2011, but also antagonize toxicity of chemotherapy agents (Mao et al 2015). This makes procyanidins possible to act as protective agents during the course of chemotherapy.…”

Section: Groups Ldh(u/l) Alt(u/l) Ast (U/l) Ck (U/l)mentioning

confidence: 99%

Grape Seed Proanthocyanidins Extract Prevents Cisplatin-induced Cardiotoxicity in Rats

Yanna

Gao

Guo

et al. 2016

FSTR

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Cisplatin-treated rats experienced a significant elevation of serum activities of lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and creatine kinase (CK). These effects were accompanied by significant increases in the levels of malondialdehyde (MDA) and nitric oxide (NO), and decreases in the glutathione (GSH) content, and the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in cardiac tissues. Pathological examination revealed that cisplatin caused significant cardiac damage in rats.Grape seed proanthocyanidins extract (GSPE) administration produced amelioration in biochemical indices of cardiotoxicity, lipid peroxidation, oxidative stress, as well as histological change when compared to group cisplatin alone. GSPE were shown to be potential candidates to ameliorate cisplatin-induced cardiotoxicity.

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Effect of Grape Procyanidins on Tumor Angiogenesis in Liver Cancer Xenograft Models

Cited by 30 publications

References 29 publications

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Dietary Natural Products for Prevention and Treatment of Liver Cancer

Grape Seed Proanthocyanidins Extract Prevents Cisplatin-induced Cardiotoxicity in Rats

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