Grape Seed Proanthocyanidins Extract Prevents Cisplatin-induced Cardiotoxicity in Rats

Yanna, Lian; Gao, Liping; Guo, Peipei; Zhao, Yihong; Lin, Ter-Yun

doi:10.3136/fstr.22.403

Cited by 11 publications

(13 citation statements)

References 29 publications

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“…Comprising a mix of bioflavonoids with biological activity (e.g., oligomeric proanthocyanidins), GSPE can have protective effect against hypertrophy and cellular infiltrations of cardiac muscle fibre cells caused by EST by diminishing the levels of free radicals and lipid peroxidation. From this perspective, the study concurred not only with Razmaraii et al [46], who found that GSPE protected against cardiotoxicity caused by doxorubicin in Wistar rats, but also with Lian et al [47], who observed that cardiotoxicity, lipid peroxidation, oxidative stress, and cardiac damage caused by cisplatin were alleviated by GSPE.…”

Section: Discussionsupporting

confidence: 81%

Evaluation of the Cardiac Protection Conferred by Proanthocyanidins in Grape Seeds against Development of Ehrlich Solid Tumors in Mice

Aldubayan

2020

BioMed Research International

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Examination of the antineoplastic effects of a range of chemical compounds is often undertaken via the transplantable tumor model of Ehrlich solid tumor (EST), which is a simulation of breast cancer. The purpose of this study was to explore how cardiac toxicity, damage, oxidative stress, and changes in the expressions of TNFα and apoptotic P53 triggered by EST could be countered with grape seed proanthocyanidins (GSPE). To that end, 50 female mice were used, with arbitrary and equal distribution into five groups, namely, the control group (G1), GSPE group (G2), EST group (G3), GSPE + EST (G4; cotreatment consisted of mice that received GSPE treatment at the beginning of EST induction over a period of 14 days), and EST + GSPE (G5; posttreatment consisted of mice with EST that received GSPE treatment for 14 days following the 14 days since the induction of EST). By comparison with the control group, the EST group had significantly higher levels of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), creatine kinase MB (CK-MB), myoglobin, cardiac TBARS, nitric oxide (NO), total thiol and hydrogen peroxide, cardiac damage, and expression of P53 and TNFα. On the other hand, the EST group had significantly lower levels of cardiac catalase and total antioxidant (TAC) than the control group. Furthermore, better improvement in cardiac toxicity, oxidative stress, damage, apoptosis, and TNFα expressions was displayed by the cotreated (GSPE + EST) group than by the posttreated (EST + GSPE) group. This led to the conclusion that GSPE conferred cardiac protective and antioxidant effects against EST. This finding calls for more investigation on the benefits of grape seeds as adjuvant agents to prevent and treat cardiac toxicity.

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Section: Discussionsupporting

confidence: 81%

Evaluation of the Cardiac Protection Conferred by Proanthocyanidins in Grape Seeds against Development of Ehrlich Solid Tumors in Mice

Aldubayan

2020

BioMed Research International

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“…The results of the present study were confirmed by the results of Al-Sowayan [61] who reported that rats injected with DOX showed a significant (P<0.05) increase the level of MDA compared to the control groups.GSPE (200 mg/kg/day) along with DOX significantly caused an improvement in MDA and this may be due to the polyphenolic content of GSPE which scavenge free radicals and act as good antioxidants against lipid peroxidation in the phospholipid bilayer [62]. Also, Lian et al [53] showed that myocardial MDA level of lipid peroxidation was significantly increased in the cisplatin administered group, comparing to control group (P < 0.05), however the administration of GSPE reduced MDA level in heart tissues with a significant milder pathological change caused by cisplatin. These observations indicated that GSPE had protective effect on cisplatin induced oxidative stress in cardiac tissue.…”

Section: Serum Malondialdehyde (Mda) and Total Antioxidant Capacity (Tac) In Experimental Groupsmentioning

confidence: 98%

“…This indicated that treatment with GS and MP extracts caused an improvement of CP toxicity and these results were confirmed by microscopic examination of heart and liver tissue which cause improvement in heart and liver tissue. [53].…”

Section: Cardiac and Hepatic Function Enzymes In Experimental Groupsmentioning

confidence: 99%

Effect of Grape Seeds (Vitis vinifera L.) and Mandarin Peels (Citrus reticulate L.) Extracts on the Cardiotoxicity Induced by Cyclophosphamide in Rats

Mohamed¹,

El-Fattah²,

Barakat³

et al. 2021

ARRB

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Aims: The current study was developed to investigate the influence of grape seeds (GS) and mandarin peels (MP) extracts as powerful antioxidants on the cardiotoxicity induced by cyclophosphamide (CP) in rats. Place of Study: Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University. Methodology: Sixty adult male Sprague-Dawley rats were divided into 6 groups. Group (1): Rats were received distilled water daily orally for 6 weeks and injected interperitoneally (i.p) with saline (0.9 %) (2.5 ml / kg BW) as single dose at the end of the sixth week of experiment. Group (2): Rats were received distilled water orally and injected with single dose of cyclophosphamide which dissolved in saline (200 mg/kg BW. i.p.) at the end of the sixth week of experiment. Groups (3 and 4): Rats were received grape seeds extracts low and high doses (150 and 300 mg /kg BW), respectively daily orally for 6 weeks then injected with cyclophosphamide as group 2. Groups (5 and 6): Rats were received mandarin peels extracts low and high doses (150 and 300 mg /kg BW), respectively daily orally for 6 weeks then injected with cyclophosphamide as group 2. Results: Our results documented that CP caused a significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALK-P), creatine kinase (CK-MB), lactate dehydrogenase (LDH), creatine kinase (CK) enzymes activity and serum malondialdehyde (MDA) level. While total antioxidant capacity level (TAC) showed a significant decrease. On the other hand cardiac catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and cardiac β cell lymphoma (Bcl-2) level showed a significant decrease in CP group while cardiac p53, caspase-3 and DNA fragmentation levels showed a significant increase in CP intoxicated group. Also, some histopathological changes were observed in liver and heart tissues in CP group. Oral administration of GS and MP caused an ameliorative effect in oxidative and apoptotic biomarkers, liver and heart function enzymes activity with an improvement of histopathological changes in liver and heart tissues. Conclusion: Our data proved that the protective effect of grape seeds and mandarin peels in cyclophosphamide intoxicated group may be due to their antioxidant, anti-inflammatory and anti- apoptotic properties.

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“…The subsequent DNA produced starts apoptosis. Study demonstrated the cardiotoxic response of cisplatin may cause electrocardiographic changes, toxic effect of free radicals, mitigate the lipid peroxidation which was diminished by concentrate of grape seed proanthocyanidins (Lian et al, 2016). Expanded oxidative stress and histopathological injury have been involved in the cardiotoxicity that constrains the clinical Page 14 / 23 use of cisplatin (CP) as an anti-cancer drug which was then analysed by managing cisplatin administration after treatment by hesperidin (Oguzturk et al, 2016).…”

Section: Cisplatinmentioning

confidence: 99%

A conglomeration of preclinical models related to myocardial infarction

Ahsan

Mahmood

Usmani

et al. 2020

Braz. J. Pharm. Sci.

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Cardiovascular diseases are the main source of death and morbidity in developed and developing nations. Animal models are required to propel our understanding of the pathogenesis, increase our knowledge, disease progress, and mechanism behind cardiovascular disorder, providing new approaches focused to improve the diagnostic and the treatment of these pathological conditions and additionally to test various therapeutic ways to deal with tissue regeneration and re-establish heart working following damage. A perfect model framework ought to be reasonable, effectively controlled, reproducible, and physiologically illustrative of human disease, show cardinal signs and pathology that resembles after the human ailment and ethically stable. The decision of selection of animal model should be considered precisely since it influences exploratory results and whether results of the research can be sensibly matched with the human. In this way, no specific technique splendidly reproduces the human disease, and relying upon the model, extra cost burden, resources, infrastructure and the necessity for technical hands, should also be kept under consideration. Here we have discussed and compiled various methods of inducing myocardial infarction in animals, basically by surgery, chemicals and through genetic modification, this may benefit the researchers in getting a complied data regarding various methods through which they can induce myocardial infarction in animals.

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Grape Seed Proanthocyanidins Extract Prevents Cisplatin-induced Cardiotoxicity in Rats

Cited by 11 publications

References 29 publications

Evaluation of the Cardiac Protection Conferred by Proanthocyanidins in Grape Seeds against Development of Ehrlich Solid Tumors in Mice

Evaluation of the Cardiac Protection Conferred by Proanthocyanidins in Grape Seeds against Development of Ehrlich Solid Tumors in Mice

Effect of Grape Seeds (Vitis vinifera L.) and Mandarin Peels (Citrus reticulate L.) Extracts on the Cardiotoxicity Induced by Cyclophosphamide in Rats

A conglomeration of preclinical models related to myocardial infarction

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