Effect of high molecular weight hyaluronic acid in treatment of osteoarthritic temporomandibular joints of rats

Tolba, Yasmine M.; Omar, Sanaa H.; Nagui, Dina; Nawwar, Muhammad A.

doi:10.1016/j.archoralbio.2019.104618

Cited by 20 publications

(24 citation statements)

References 32 publications

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“…In the group in which OA was induced without treatment, there was abnormal disorganization and stratification in the tissue layers, and bone sclerosis. In the group in which HMWHA was administered, there was a reduction in pathological changes and restoration of the normal structure of TMJ, with a simultaneous decrease in MMP-3 levels [90]. Thus, the obtained results show the chondroprotective effects exerted by HA.…”

Section: Osteoarthritismentioning

confidence: 55%

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation

2021

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Hyaluronic acid (HA) is a natural polymer, produced endogenously by the human body, which has unique physicochemical and biological properties, exhibiting desirable biocompatibility and biodegradability. Therefore, it has been widely studied for possible applications in the area of inflammatory diseases. Although exogenous HA has been described as unable to restore or replace the properties and activities of endogenous HA, it can still provide satisfactory pain relief. This review aims to discuss the advances that have been achieved in the treatment of inflammatory diseases using hyaluronic acid as a key ingredient, essentially focusing on studies carried out between the years 2017 and 2021.

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Section: Osteoarthritismentioning

confidence: 55%

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation

2021

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“…Because of the increased amount of LMW HA within osteoarthritic TMJs, some have suggested the use of HMW HA in the treatment of TMJ OA. Tolba et al [ 33 ] observed that intraarticular injections of HMW HA led to a satisfactory reduction in osteoarthritic changes within the TMJs. Similar observations were presented by Duygu et al [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…The authors noticed that better results regarding the repairing processes of the cartilage and the articular disc were obtained with the usage of the LMW HA. Although the results presented by the above-listed authors [ 24 , 33 , 34 , 35 ] seem very promising, it must be emphasized that all of these studies were performed on different animal models, namely rats [ 33 , 35 ] and rabbits [ 24 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis—A Systematic Review

Derwich¹,

Mituś-Kenig

Pawłowska

2021

IJMS

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Temporomandibular joint osteoarthritis (TMJ OA) is a low-inflammatory disorder with multifactorial etiology. The aim of this review was to present the current state of knowledge regarding the mechanisms of action and the efficacy of hyaluronic acid (HA), corticosteroids (CS) and platelet-rich plasma (PRP) in the treatment of TMJ OA.: The PubMed database was analyzed with the keywords: “(temporomandibular joint) AND ((osteoarthritis) OR (dysfunction) OR (disorders) OR (pain)) AND ((treatment) OR (arthrocentesis) OR (arthroscopy) OR (injection)) AND ((hyaluronic acid) OR (corticosteroid) OR (platelet rich plasma))”. After screening of 363 results, 16 studies were included in this review. Arthrocentesis alone effectively reduces pain and improves jaw function in patients diagnosed with TMJ OA. Additional injections of HA, either low-molecular-weight (LMW) HA or high-molecular-weight (HMW) HA, or CS at the end of the arthrocentesis do not improve the final clinical outcomes. CS present several negative effects on the articular cartilage. Results related to additional PRP injections are not consistent and are rather questionable. Further studies should be multicenter, based on a larger group of patients and should answer the question of whether other methods of TMJ OA treatment are more beneficial for the patients than simple arthrocentesis.

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“…(21,22) Most previous studies have focused on the therapeutic effects of PRP and HA in the treatment of TMJ-OA but few studies have focused on the efficacy and treatment mechanism of a combination of PRP and HA. (23)(24)(25) Recently, increasing evidence has supported the use of PRP combined with HA for the treatment of knee osteoarthritis. (26,27) Marmotti et al (28) and Yan et al (29) found that the addition of HA to PRP could effectively promote the proliferation of chondrocytes and improve cartilage repair.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Histological Evaluation of different intra-articular injections as therapy for Temporomandibular Joint Osteoarthritis in Rats

Arafat

Kamel

2021

Egyptian Dental Journal

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Introduction: Temporomandibular joint (TMJ) osteoarthritis is usually treated by intraarticular injection of medications. Intra-articular hyaluronic acid (HA) injection reduces friction and stress on the joint cartilage through lubrication, chondro-protection and proteoglycans synthesis. Platelet Rich Plasma (PRP) with its high concentration of growth factors plays a great role in joint repair through enhancing osteo-inductivity, and chondrogenic differentiation. This study aims at comparing intra-articular injection of combination of hyaluronic acid and platelet rich plasma to intra-articular injection of each of them alone.Materials and Methods: 24 young adult male 250-300 grams albino rats were used in the current study divided randomly into 4 groups: Group 1 (control) in which animals were left without treatment. Group 2 which was subdivided into 3 study groups, in Group 2A: the animals received 2 doses of HA, in Group 2B: the animals received 2 doses of PRP, and in Group 2C: the animals received 2 doses of combined PRP and HA. After 28 days, the animals were sacrificed and histological analysis was performed. Synovial fluid Samples were extracted before each intraarticular injection, the concentration of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) were detected and statistically analyzed.Results: Group 2C showed superior findings to the other 2 study groups regarding fibrocartilage and bone regeneration, while Group 2B was superior to group 2A regarding the study parameters. Conclusion:Intra-articular injection of combination of PRP and HA is superior to intraarticular injection of HA or PRP alone for the treatment of TMJ osteoarthritis in rats.

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Effect of high molecular weight hyaluronic acid in treatment of osteoarthritic temporomandibular joints of rats

Cited by 20 publications

References 32 publications

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation

Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis—A Systematic Review

Biochemical and Histological Evaluation of different intra-articular injections as therapy for Temporomandibular Joint Osteoarthritis in Rats

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