Effect of histamine on the diameter of skeletal muscle fibers in mice

Serotonin Antagonist Increases Longevity in Mice With Hereditary Muscular Dystrophy.

“…Serotonin and histamine will induce histologic changes, such as sarcoplasmic necrosis, myofibrillar degeneration, and central rowing of muscle nuclei in skeletal muscle of normal mice ( 3,8). Large numbers of tissue mast cells ( 5 ) , which contain the biogenic amines, histamine and serotonin, and high concentrations of histamine in skin(6) and muscles ( 7 ) , and of serotonin in the spleen of mice with hereditary muscular dystrophy ( 2 ) suggest a possible interrelationship between the biogenic amines and the development of the myopathy.…”