Effect of HIV‐1 Infection on Antimalarial Treatment Outcomes in Uganda: A Population‐Based Study

Kamya, Moses R.; Gasasira, Anne; Yeka, Adoke; Bakyaita, Nathan; Nsobya, Samuel L.; Francis, Damon; Rosenthal, Philip J.; Dorsey, Grant; Havlir, Diane V.

doi:10.1086/498577

Cited by 140 publications

(105 citation statements)

References 23 publications

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“…The findings are in line with a growing body of evidence from elsewhere in sub-Saharan Africa that malaria tends to occur with increased frequency and severity in HIV-infected adults. This underlines the need for new strategies of HIV testing and counselling for adults with uncomplicated falciparum malaria (Kamya et al, 2006).…”

Section: East Africamentioning

confidence: 99%

Grand challenges in chronic non-communicable diseases

Daar

Сингер

Persad

et al. 2007

Nature

557

379

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Section: East Africamentioning

confidence: 99%

Grand challenges in chronic non-communicable diseases

Daar

Сингер

Persad

et al. 2007

Nature

557

379

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“…Areas of malaria and HIV endemicity share a wide geographic overlap, putting millions of people at risk of co-infection and consequently at risk for more severe clinical disease [2][3][4][5][6][7][8][9][10] . The two diseases negatively interact.…”

Section: Introductionmentioning

confidence: 99%

An <em>In Vitro</em> Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Finney

Serghides

2015

JoVE

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Malaria and HIV co-infection is a growing health priority. However, most research on malaria or HIV currently focuses on each infection individually. Although understanding the disease dynamics for each of these pathogens independently is vital, it is also important that the interactions between these pathogens are investigated and understood.We have developed a versatile in vitro model of HIV-malaria co-infection to study host immune responses to malaria in the context of HIV infection. Our model allows the study of secreted factors in cellular supernatants, cell surface and intracellular protein markers, as well as RNA expression levels. The experimental design and methods used limit variability and promote data reliability and reproducibility.All pathogens used in this model are natural human pathogens (Plasmodium falciparum and HIV-1), and all infected cells are naturally infected and used fresh. We use human erythrocytes parasitized with P. falciparum and maintained in continuous in vitro culture. We obtain freshly isolated peripheral blood mononuclear cells from chronically HIV-infected volunteers. Every condition used has an appropriate control (P. falciparum parasitized vs. normal erythrocytes), and every HIV-infected donor has an HIV uninfected control, from which cells are harvested on the same day. This model provides a realistic environment to study the interactions between malaria parasites and human immune cells in the context of HIV infection. Video LinkThe video component of this article can be found at

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“…Due to their overlapping distribution, coinfection with malaria and HIV is therefore bound to be common in the area. Coinfection with malaria and HIV is thought to have a synergistic effect, with studies reporting that repeated infection with malaria leads to a more rapid decline in CD4 + T cells overtime, meanwhile malaria coinfection with HIV results in more episodes of symptomatic malaria [11], and more episodes of severe or complicated malaria including death in both children and adults [12] [13] [14] [15] [16]. The risk of severe anaemia is also higher in HIV patients coinfected with malaria compared to HIV patients without malaria [17] [18].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Coinfection with Malaria and HIV among Children in Yaoundé, Cameroon: A Cross-Sectional Survey Performed in Three Communities in Yaoundé

Kwenti¹,

Edo²,

Ayuk³

et al. 2017

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Background: Malaria and HIV are endemic in Cameroon. But data on the prevalence of coinfection with malaria and HIV in Cameroonian children are essentially absent. This study was aimed at determining the prevalence of coinfection with malaria and HIV among children in Yaoundé, so as to advice control policies. Methods: In a cross-sectional survey, children (≤15 years) were recruited from 3 communities in Yaoundé namely: Efoulan, Biyem-assi and Cité-verte. A semi-structured questionnaire was used to collect demographic data. Participants were screened for malaria parasites by the examination of Giemsa-stained blood films meanwhile participants were screened for HIV following Cameroon's national algorithm. The Pearson's chi-square test was performed as part of the statistical analyses. Statistical significance was set at p < 0.05. Result: Three hundred and ten (310) children took part in the study. The mean age (±SD) of the participants was 75.64 (±63.23) months and a majority of them were males (56

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Effect of HIV‐1 Infection on Antimalarial Treatment Outcomes in Uganda: A Population‐Based Study

Cited by 140 publications

References 23 publications

Grand challenges in chronic non-communicable diseases

Grand challenges in chronic non-communicable diseases

An <em>In Vitro</em> Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Prevalence of Coinfection with Malaria and HIV among Children in Yaoundé, Cameroon: A Cross-Sectional Survey Performed in Three Communities in Yaoundé

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Effect of HIV‐1 Infection on Antimalarial Treatment Outcomes in Uganda: A Population‐Based Study

Cited by 140 publications

References 23 publications

Grand challenges in chronic non-communicable diseases

Grand challenges in chronic non-communicable diseases

An <em>In Vitro</em> Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Prevalence of Coinfection with Malaria and HIV among Children in Yaound&#233;, Cameroon: A Cross-Sectional Survey Performed in Three Communities in Yaound&#233;

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Prevalence of Coinfection with Malaria and HIV among Children in Yaoundé, Cameroon: A Cross-Sectional Survey Performed in Three Communities in Yaoundé