Effect of Hizikia fusiforme Extracts on Antioxidant Enzyme Activity and Vitamin E Concentration in Rats

김향숙,; 최은옥,; 박철,; 최영현,; 현숙경,; 황혜진,

doi:10.3746/jkfn.2011.40.11.1556

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Park et al (2005) found that ethanol extract from boiled water of H. fusiformis (EBH) showed potent DPPH radical-and peroxynitritescavenging activities and increased reducing power, suggesting that total phenolic content correlated with the DPPH radical scavenging and reducing power. An in vivo experiment indicated that water extracts from H. fusiformis increased serum superoxide dismutase activity and liver alpha-tocopherol levels and decreased plasma malondialdehyde (MDA) concentration in rats (Kim et al, 2011). Wu et al (2013) found that water-soluble polysaccharides from H. fusiformis showed free radical scavenging activities against hydroxyl radical and DPPH radical in vitro, while decreasing MDA levels and elevating hepatic superoxide dismutase activities in vivo.…”

Section: Resultsmentioning

confidence: 99%

Effect of Hizikia fusiformis extracts on reactive oxygen species mediated oxidative damage

Baek¹,

Lim²

2017

Int. J. Adv. Res. Biol. Sci

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We investigated the effect of Hizikia fusiformis extracts on the production of cellular reactive oxygen species (ROS) in human fibroblast cell line HT-1080to evaluate their antioxidant activities. The H 2 O 2 -induced ROS generation was measured using a dichlorofluorescein-diacetate (DCFH-DA) assay. The acetone+methylene chloride (A+M)and methanol (MeOH) extracts dosedependently decreased the level of ROS production induced by H 2 O 2 in comparison with the levels observed in the control without the extracts. Treatments with A+M and MeOH extracts for 120 min reduced ROS generation by 86% and 77%, respectively. All tested fractions decreased ROS production in a concentration-dependent manner. Treatments with n-hexane,85% aqueous MeOH and n-butanol (BuOH) fractions resulted in54%, 54% and 31% ROS inhibition, respectively. These results indicate that both A+M and MeOH extracts of H. fusiformis had a stronger effect in reducing ROS production. This present preliminary study suggests that extracts from H. fusiformis have nutraceutical value with potent antioxidant activity that alleviates radical-induced damage.

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Section: Resultsmentioning

confidence: 99%

Effect of Hizikia fusiformis extracts on reactive oxygen species mediated oxidative damage

Baek¹,

Lim²

2017

Int. J. Adv. Res. Biol. Sci

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“…해양생물은 독특한 환경으로 인하여 육상생물에 없는 특 유의 대사과정을 가지고 있어 다양한 신규 생리활성 물질의 탐색 가능성이 높다. 또한, 해양생물에 대한 연구는 육상생물 에 대한 연구에 비해 아직 그 수가 많지 않아서 새로운 천연물 질의 개발에 대한 기대가 높은 편이다 [15].…”

Section: 서 론unclassified

Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Jeon¹,

Kim²,

Jang³

et al. 2012

Journal of Life Science

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Melanin synthesis is catalyzed by tyrosinase. To investigate the whitening effect of Hizikia fusiformis, fractions from ethanol extract of H. fusiformis were prepared by a systematic fractionation procedure with solvents such as methanol, hexane, butanol, and H2O. The ethanol extract and its fractions were then subjected to evaluate the inhibitory effects on the tyrosinase activity and melanin synthesis in murine B16F10 melanoma cells. The ethanol extract and aqueous fraction exhibited a whitening effect with no cytotoxicity. The ethanol extract showed the highest whitening effect among the samples. The inhibitory effect of 100 μg/ml of ethanol extract was higher than that of 10 μg/ml of arbutin, but it was lower than that of 10 μg/ml of kojic acid. Furthermore, the inhibitory effects of 100 μg/ml of methanol, hexane, butanol, and aqueous fractions were similar to those of 10 μg/ml of arbutin. The antioxidant activities were examined by comparing the results with that of ascorbic acid as a positive control. The ethanol extract and aqueous fraction showed relatively higher DPPH radical-scavenging activities compared with the other samples. Furthermore, 500 μg/ml of ethanol extract and aqueous fraction diminished LPS-induced iNOS expression to 82 and 80%, respectively. These results suggest that ethanol extract and aqueous fraction of H. fusiformis could be used as cosmetic ingredients for whitening and skin protection effects.

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“…Seaweed is consumed as food in large quantities in Korea, Japan, and China. The carbohydrates contained in seaweed are effective in promoting intestinal motility, heavy metal elimination, and improving hyperlipemia (Lee and Kim 2008;Kim et al 2011). Hizikia fusiforme is not only a good source of dietary fiber but also fucoidans, in particular jaminaran, a neutral polysaccharide with functional properties such as blood coagulation and immunity enhancement (Wua et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Hizikia fusiforme and Chlorella sp. extracts against lead acetate-induced hepatotoxicity in rats

et al. 2019

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In the present study, the protective effects of Hizikia fusiforme and Chlorella sp. extracts on lead acetate-induced hepatotoxicity were investigated. Hepatic damage was induced in rats by intraperitoneal (i.p.) injection of lead acetate and the protective effects of H. fusiforme (HZK) and Chlorella sp. (CHL) extracts on lead acetate-induced hepatic damage in rat liver were examined. The results revealed significantly increased glutamic oxaloacetate and glutamic pyruvic transaminase levels in the group treated with lead acetate only (Pb group); oral administration of HZK and CHL extracts tended to decrease the enzyme levels similar to those observed in the control group. Regarding antioxidant enzymes, superoxide dismutase activity was increased in the Pb group and decreased in a concentration-dependent manner in the HZK-and CHL-treated groups. Glutathione levels were increased in a concentration-dependent manner in the HZK-and CHL-treated groups. There was no significant difference in catalase activity. Western blot analysis showed inflammation-related protein expression in mitogen-activated protein kinase and Nrf2 pathways was affected in the HZK-and CHL-treated groups. Therefore, HZK and CHL extracts exerted antioxidant and anti-inflammatory effects against lead acetate-induced hepatotoxicity. Development of functional health foods containing HZK and CHL extracts, which have hepatoprotective effects against inhaled lead acetate, should be considered.

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Effect of Hizikia fusiforme Extracts on Antioxidant Enzyme Activity and Vitamin E Concentration in Rats

Cited by 4 publications

References 14 publications

Effect of Hizikia fusiformis extracts on reactive oxygen species mediated oxidative damage

Effect of Hizikia fusiformis extracts on reactive oxygen species mediated oxidative damage

Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Protective effects of Hizikia fusiforme and Chlorella sp. extracts against lead acetate-induced hepatotoxicity in rats

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