Effect of hyperglycemia on the growth hormone response to L-dopa in diabetic subjects

Abstract

Plasma growth hormone (GH) levels were measured before and after oral administration of L-dopa in 8 insulin-dependent juvenile diabetic patients, and in 6 non insulin-dependent maturity-onset diabetics, while they were hyperglycemic, and values were compared with those of normal children and adult subjects. Maturity-onset diabetics failed to show an increase in serum GH levels after L-dopa administration, while serum peak GH values of juvenile diabetic patients were not significantly different from those of normal adults and children. Hyperglycemia thus failed to prevent L-dopa induced growth hormone response in insulin-dependent juvenile diabetic patients.

Effect of Three Days Nifedipine Administration on Thyroid Response to TSH

“…In vitro and in vivo studies demonstrated that calcium antagonists (CA) may affect the basal and/or the stimulated secretion of several hormones (Millard and Struthers 1984). In vivo, verapamil inhibited TRH-stimulated TSH release ( Barbarino and de Marinis 1980). However, the effect of CA at thyroid level has never been studied.…”

Pituitary Function Assessment in Short Stature by a Combined Hormonal-Stimulation Test

“…Nineteen of the 28 4'°c m/y or greater and a predicted wt height less than the target adult height for the family by more than 2.5 SDs.…”