Effect of Hyperglycemia to The mRNA Level and Protein Expression of Perlecan at Rat Model of Osteoarthritis with Diabetes Mellitus Type 1

Njoto, Ibrahim; Kalim, Handono; Soeatmadji, Djoko Wahono; Handono, Kusworini; Fatchiyah, Fatchiyah

doi:10.5455/medarh.2019.73.144-148

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…The study conducted by Njoto I. et al confirms that DM with characteristic perlecan expression is a trigger for OA [ 30 , 31 ]. Radojčić MR et al revealed that there are associations between the novel ECM biomarker C1M and local and systemic interleukin 6 with synovitis and pain, finding a net loss of collagen elevation and increase in levels of MMP-2, -9, and -13.…”

Section: Rheumatoid Arthritis (Ra) and T1dmmentioning

confidence: 96%

Ligament Alteration in Diabetes Mellitus

Adamska

Stolarczyk

Gondek

et al. 2022

JCM

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Connective tissue ageing is accelerated by the progressive accumulation of advanced glycation end products (AGEs). The formation of AGEs is characteristic for diabetes mellitus (DM) progression and affects only specific proteins with relatively long half-lives. This is the case of fibrillar collagens that are highly susceptible to glycation. While collagen provides a framework for plenty of organs, the local homeostasis of specific tissues is indirectly affected by glycation. Among the many age- and diabetes-related morphological changes affecting human connective tissues, there is concurrently reduced healing capacity, flexibility, and quality among ligaments, tendons, bones, and skin. Although DM provokes a wide range of known clinical disorders, the exact mechanisms of connective tissue alteration are still being investigated. Most of them rely on animal models in order to conclude the patterns of damage. Further research and more well-designed large-cohort studies need to be conducted in order to answer the issue concerning the involvement of ligaments in diabetes-related complications. In the following manuscript, we present the results from experiments discovering specific molecules that are engaged in the degenerative process of connective tissue alteration. This review is intended to provide the report and sum up the investigations described in the literature concerning the topic of ligament alteration in DM, which, even though significantly decreasing the quality of life, do not play a major role in research.

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Section: Rheumatoid Arthritis (Ra) and T1dmmentioning

confidence: 96%

Ligament Alteration in Diabetes Mellitus

Adamska

Stolarczyk

Gondek

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…For example, chronic hyperglycemia has been suggested to adversely affect the functions and structures of articular cartilage, bone, tendons and ligaments, and synovium, all of which have been involved in the pathogenesis of OA [7]. Moreover, a subsequent study in rat model of OA showed that hyperglycemia increased the severity of OA via decreasing the mRNA and protein expression of perlecan [8]. Besides, a recent study in guinea pig showed that plasma glucose concentration was positively correlated with proteoglycan loss, suggesting hyperglycemic stress after rapamycin treatment was related to the deteriorated OA [9].…”

Section: Introductionmentioning

confidence: 99%

Association Between Prediabetes and Osteoarthritis: A Meta-Analysis

Zhou

Liu

2022

Horm Metab Res

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Some studies have suggested that diabetes may be a risk factor for osteoarthritis. However, whether prediabetes is also associated with osteoarthritis has not been comprehensively examined. We performed a meta-analysis to evaluate the relationship between prediabetes and osteoarthritis. This meta-analysis included relevant observational studies from Medline, Embase, and Web of Science databases. A random-effect model after incorporation of the intra-study heterogeneity was selected to pool the results. Ten datasets from six observational studies were included, which involved 41 226 general adults and 10 785 (26.2%) of them were prediabetic. Pooled results showed that prediabetes was not independently associated with osteoarthritis [risk ratio (RR): 1.07, 95% confidence interval (CI): 1.00 to 1.14, p=0.06, I2=0%]. Sensitivity limited to studies with adjustment of age and body mass index showed consistent result (RR: 1.06, 95% CI: 0.99 to 1.14, p=0.09, I2=0%). Results of subgroup analyses showed that prediabetes was not associated with osteoarthritis in cross-sectional or cohort studies, in studies including Asian or non-Asian population, or in studies with different quality scores (p for subgroup difference>0.10). Besides, prediabetes was not associated with osteoarthritis in men or in women, in studies with prediabetes defined as impaired fasting glucose, impaired glucose tolerance, or HbA1c (approximately 39–46 mmol/mol). Moreover, prediabetes was not associated with overall osteoarthritis, and knee or hip osteoarthritis. Current evidence does not support that prediabetes is independently associated with osteoarthritis in adult population.

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