Effect of <i>Carica papaya</i> Extract toward Incised Wound Healing Process in Mice (<i>Mus musculus</i>) Clinically and Histologically

Hakim, Rachmi Fanani; Fakhrurrazi,; Dinni,

doi:10.1155/2019/8306519

Cited by 25 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The concepts were further supported by in vivo studies evaluating different parts of Carica papaya on incised, burned, and diabetic wounds respectively. The recent findings show that Carica papaya fruit and seed extracts demonstrated dose-dependent increment in hydroxyproline, fibrillation, epithelial thickness, shortened wound contraction, and epithelialization time [ 69 , 70 , 71 , 72 ].…”

Section: Carica Papaya Counteracts Oxidative Stress In Inflammation Skin Aging and Healing Chronic Diseases And Cancersmentioning

confidence: 99%

“…Cysteine endopeptidases including papain and chymopapain showed wound healing activity that can be attributed to their proteolytic wound debridement and antibacterial effects [ 63 , 64 , 70 , 72 ]. This was established by an in vivo study using papain-based wound cleanser.…”

Section: Carica Papaya Counteracts Oxidative Stress In Inflammation Skin Aging and Healing Chronic Diseases And Cancersmentioning

confidence: 99%

See 1 more Smart Citation

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

Kong

Jong

Balakrishnan

et al. 2021

Biology

View full text Add to dashboard Cite

Oxidative stress is a result of disruption in the balance between antioxidants and pro-oxidants in which subsequently impacting on redox signaling, causing cell and tissue damages. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases and cancers but these conditions can be managed properly with the aid of antioxidants. This review features various studies to provide an overview on how Carica papaya help counteract oxidative stress via various mechanisms of action closely related to its antioxidant properties and eventually improving the management of various oxidative stress-related health conditions. Carica papaya is a topical plant species discovered to contain high amounts of natural antioxidants that can usually be found in their leaves, fruits and seeds. It contains various chemical compounds demonstrate significant antioxidant properties including caffeic acid, myricetin, rutin, quercetin, α-tocopherol, papain, benzyl isothiocyanate (BiTC), and kaempferol. Therefore, it can counteract pro-oxidants via a number of signaling pathways that either promote the expression of antioxidant enzymes or reduce ROS production. These signaling pathways activate the antioxidant defense mechanisms that protect the body against both intrinsic and extrinsic oxidative stress. To conclude, Carica papaya can be incorporated into medications or supplements to help manage the health conditions driven by oxidative stress and further studies are needed to investigate the potential of its chemical components to manage various chronic diseases.

show abstract

Section: Carica Papaya Counteracts Oxidative Stress In Inflammation Skin Aging and Healing Chronic Diseases And Cancersmentioning

confidence: 99%

Section: Carica Papaya Counteracts Oxidative Stress In Inflammation Skin Aging and Healing Chronic Diseases And Cancersmentioning

confidence: 99%

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

Kong

Jong

Balakrishnan

et al. 2021

Biology

View full text Add to dashboard Cite

show abstract

“…The faster healing time reduces the possibility of complications in the injury, these in turn reduce the costs that may be involved in prolonging the treatment. 21 In the histopathological analysis of the groups that received the purple sweet potato gels, an active recovery of the stratum corneum, granular, spinous and basal cells is shown. These later will be in charge of replacing the dead epidermal cells.…”

Section: Discussionmentioning

confidence: 96%

Effect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice

Silva-Correa¹,

Ortiz-Noriega²,

Torre³

et al. 2021

View full text Add to dashboard Cite

Background: Ipomoea batatas (L.) Lam. (I. batatas) is a root native from South America that is characterized by its antioxidant, antimicrobial and anti-inflammatory properties. These properties contribute to the wound healing process. Objective: To evaluate the healing activity of a gel based on I. batatas on dermal wound healing in mice. Material and methods: An acid ethanolic extract (1.5 N hydrochloric acid: Ethanol 96 ° 15:85, v / v) was prepared with the peels of the roots of I. batatas "purple sweet potato", which was incorporated into the formulations 0.5% and 1% gel. Mus musculus Balb / c with induced injury were distributed in four experimental groups: Group I (Control), which did not receive any treatment. Group II (Gel base), Group III (Gel I. batatas 0.5%) and Group IV (Gel I. batatas 1%) received the daily administration of topical treatments for 14 days. Wound closure was determined during the experimentation time, then they were euthanized with sodium pentobarbital 60 mg / kg / pc v.ip. to obtain skin samples for histopathological analysis. Results: Group IV shows a higher percentage of wound closure, which is also evidenced in histopathological changes. Conclusions: The 1% gel based on the ethanolic extract of the peels of the roots of Ipomoea batatas (L.) Lam. they show healing activity in wounds induced in mice, being the most effective treatment.

show abstract

“…Caffeic acid reduces skin erythema via inhibitory action towards NF-κB and AP-1 signaling [ 205 ]. Cysteine endopeptidases and chymopapain have proteolytic wound-debridement and antibacterial effects [ 206 , 207 , 208 , 209 ].…”

Section: Foods In Cosmetic Preparationmentioning

confidence: 99%

The New Challenge of Green Cosmetics: Natural Food Ingredients for Cosmetic Formulations

2021

View full text Add to dashboard Cite

Nowadays, much attention is paid to issues such as ecology and sustainability. Many consumers choose "green cosmetics", which are environmentally friendly creams, makeup, and beauty products, hoping that they are not harmful to health and reduce pollution. Moreover, the repeated mini-lock downs during the COVID-19 pandemic have fueled the awareness that body beauty is linked to well-being, both external and internal. As a result, consumer preferences for makeup have declined, while those for skincare products have increased. Nutricosmetics, which combines the benefits derived from food supplementation with the advantages of cosmetic treatments to improve the beauty of our body, respond to the new market demands. Food chemistry and cosmetic chemistry come together to promote both inside and outside well-being. A nutricosmetic optimizes the intake of nutritional microelements to meet the needs of the skin and skin appendages, improving their conditions and delaying aging, thus helping to protect the skin from the aging action of environmental factors. Numerous studies in the literature show a significant correlation between the adequate intake of these supplements, improved skin quality (both aesthetic and histological), and the acceleration of wound-healing. This review revised the main foods and bioactive molecules used in nutricosmetic formulations, their cosmetic effects, and the analytical techniques that allow the dosage of the active ingredients in the food.

show abstract

Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically

Cited by 25 publications

References 11 publications

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

Effect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice

The New Challenge of Green Cosmetics: Natural Food Ingredients for Cosmetic Formulations

Contact Info

Product

Resources

About