Effect of in ovo injection of threonine on immunoglobulin A gene expression in the intestine of Japanese quail at hatch

Kermanshahi, Hassan; Tabari, Damoon Ghofrani; Emami, Nima K.; Daneshmand, Ali; Ibrahim, Salam A.

doi:10.1111/jpn.12543

Cited by 15 publications

(9 citation statements)

References 26 publications

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“…The only exception was glycine, which was significantly decreased in urine of the rats in EE and P groups. As the most important amino acid with immunoregulatory effect, threonine can not only stimulate gene express of IgA, but also participant the generation process of immunoglobulin together with serine directly (Kermanshahi et al, 2016;Su et al, 2013). 2-Hydroxybutyrate, the metabolic product of threonine, also was found up-regulated in our results.…”

Section: The Effect Of Ee On Systemic Metabolitessupporting

confidence: 71%

Echinacea purpurea Extract Affects the Immune System, Global Metabolome, and Gut Microbiome in Wistar Rats

Wang¹,

Hou²,

Lv³

et al. 2017

JAS

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Echinacea purpurea extract, a traditional herbal food additive with dual-purpose of medicine and edible material, has been widely used for the treatment and prevention of various infectious diseases, especially for children, old aged and immunocompromised patients. Although there were numerous reports suggested E. purpurea possessed immunostimulatory and antibacterial effects in vitro, the mechanisms underlying remained to be elucidated. This study employed immunologic factors analysis, GC-TOFMS based metabolomics and 16S-rRNA-sequencing microbiome profiling technologies to explore the effects of E. purpurea on young rats, a physiological insufficient immunity status, by compared with pidotimod treatment on young rats and adult animals. E. purpurea treatment significantly increased IL-2, decreased IL-6 and affect immunoglobulins in the spleen of young rats, indicating its promotion of cellular immunity. Both the immunologic factors and the global metabolome of E. purpurea treated young rats were close to the status of mature individuals. Results of 16S-rRNA-sequencing of ileum content together with co-metabolism metabolites demonstrated that E. purpurea changed gut microbiota structure characteristically as a reducing Firmicutes phylum, especially Lactobacillus, and a rising Actinobacteria phylum including Bifidobacterium. The results were concluded that E. purpurea could potentially promote the maturation of immune and metabolism of immature rats, and also affect gut flora structure.

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Section: The Effect Of Ee On Systemic Metabolitessupporting

confidence: 71%

Echinacea purpurea Extract Affects the Immune System, Global Metabolome, and Gut Microbiome in Wistar Rats

Wang¹,

Hou²,

Lv³

et al. 2017

JAS

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“…The proportion of proline and glycine in the embryo rises with incubation time. Proline is synthesized from many different AAs, whereas the synthesis of glycine is limited to only serine and threonine . In this technique, the injection of AAs on the seventh day of incubation had shown an increase in the BW by 3.6% .…”

Section: Applications Of In Ovo Technology For Various Biological Supmentioning

confidence: 99%

“…Proline is synthesized from many different AAs, whereas the synthesis of glycine is limited to only serine and threonine. 74,75 In this technique, the injection of AAs on the seventh day of incubation had shown an increase in the BW by 3.6%. 72 Injection of arginine (35 mg per egg) and threonine (25 mg per egg) and their mixture into amnion improved feed efficiency and post-hatch growth rate of broilers.…”

Section: Amino Acidsmentioning

confidence: 99%

In ovodelivery of various biological supplements, vaccines and drugs in poultry: current knowledge

et al. 2019

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The technique of delivering various nutrients, supplements, immunostimulants, vaccines, and drugs via the in ovo route is gaining wide attention among researchers worldwide for boosting production performance, immunity and safeguarding the health of poultry. It involves direct administration of the nutrients and biologics into poultry eggs during the incubation period and before the chicks hatch out. In ovo delivery of nutrients has been found to be more effective than post‐hatch administration in poultry production. The supplementation of feed additives, nutrients, hormones, probiotics, prebiotics, or their combination via in ovo techniques has shown diverse advantages for poultry products, such as improved growth performance and feed conversion efficiency, optimum development of the gastrointestinal tract, enhancing carcass yield, decreased embryo mortality, and enhanced immunity of poultry. In ovo delivery of vaccination has yielded a better response against various poultry pathogens than vaccination after hatch. So, this review has aimed to provide an insight on in ovo technology and its potential applications in poultry production to deliver different nutrients, supplements, beneficial microbes, vaccines, and drugs directly into the developing embryo to achieve an improvement in post‐hatch growth, immunity, and health of poultry. © 2019 Society of Chemical Industry

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“…Rezaeipour, Fononi, and Irani (2012) observed that antibody titres of chicks increased as dietary threonine level increased. Increasing dietary threonine levels increased serum IgG concentration in growing pigs (Li et al, 1999) and increased mRNA expression of jejunal IgA in newly hatched chicks (Kermanshahi, Tabari, Emami, Daneshmand, & Ibrahim, 2016). In the current study, IgA and IgG concentrations in colostrum from gilts fed DT were lower compared with colostrum from gilts fed AT or ST, indicating that insufficient threonine intake may limit maternal production of colostral immune globulins.…”

Section: Discussionmentioning

confidence: 99%

Effects of deficiency and surplus dietary threonine on reproductive performance of primiparous pregnant gilts

Shi

Liu

et al. 2018

Animal Physiology Nutrition

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Dietary threonine imbalance is known to impair reproductive performances of gestating sows, but the underlying mechanisms are largely unknown. In this study, effects of deficiency and surplus dietary threonine during gestation on reproductive performance, serum metabolites and hormones concentration, and colostral nutrient and immunoglobulin contents of primiparous sows were investigated. Ninety primiparous pregnant gilts were assigned to one of the three dietary treatments with different standardized ileal digestible threonine/lysine ratios at 0.59, 0.72 and 0.85, which represented deficient (DT), adequate (AT) and surplus (ST) dietary threonine concentration respectively. Maternal body weight gain from day 80-110 of gestation was highest (p < .05) for gilts fed AT than for gilts fed DT or ST. On days 30 and 110, serum threonine concentration increases in a dose-dependent manner with the increasing of dietary threonine concentration in (p < .01), serum urea nitrogen concentration was lower (p < .01) in gilts fed AT than DT or ST, and serum insulin-like growth factor-I (IGF-I) was lowest (p < .05) for gilts fed DT. On day 110, gilts fed AT had lower serum progesterone concentration but higher concentrations of serum prolactin (p < .05) compared to DT and ST. Concentration of colostral immunoglobulin A and G from gilts fed DT was lower (p < .05) compared with gilts fed AT or ST. In conclusion, gilts with the adequate threonine intake were more able to conserve dietary amino acids to support foetal and maternal tissue gain. Deficient or ST threonine intake may induce a delay in changes in progesterone and prolactin concentrations during the prepartum period impeding the transition from pregnancy to lactation.

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Effect of in ovo injection of threonine on immunoglobulin A gene expression in the intestine of Japanese quail at hatch

Cited by 15 publications

References 26 publications

Echinacea purpurea Extract Affects the Immune System, Global Metabolome, and Gut Microbiome in Wistar Rats

Echinacea purpurea Extract Affects the Immune System, Global Metabolome, and Gut Microbiome in Wistar Rats

In ovodelivery of various biological supplements, vaccines and drugs in poultry: current knowledge

Effects of deficiency and surplus dietary threonine on reproductive performance of primiparous pregnant gilts

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