Effect of Intranasal Administration of Anti-Glutamate Antibodies after Stress Exposure on the Stress Response

Abstract

We studied the dose-dependent effect of antibodies to glutamate on the stress response in C57Bl/6 mice. The antibodies were administered immediately after stress exposure. Intranasal administration of antibodies to glutamate in doses of 150 and 250 μg/kg immediately after stress exposure was shown to reduce the stress response under conditions of combined restraint stress. This effect was most pronounced after treatment with antibodies in a dose of 250 μg/kg: we revealed a decrease in the number and severity of erosive and ulcerative lesions in the gastric mucosa, i.e. anti-glutamate antibodies have a protective effect.

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

“…Functional studies using both small and large molecules have shown delivery to the hemispheres via this mechanism despite this potential hindrance. The main driving force for uptake is the concentration gradient of the test article (Barakat et al, 2006;Evseev et al, 2010;Furrer et al, 2009;Gorbatov et al, 2010;Hoekman and Ho, 2011;Romanova et al, 2010;Sipos et al, 2010). However, there are two main factors that do impinge on the efficiency of CNS uptake of a molecule using this technique: those related to formulation, and those related to physicochemical characteristics.…”