Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats

Grapefruit Juice Suppresses Azoxymethane-induced Colon Aberrant Crypt Formation and Induces Antioxidant Capacity in Mice

“…This effect is congruent with the observed by Vanamala et al (2006), who pre-administered grapefruit pulp powder for longer time than in our case, to rats injected with 15 mg/kg of AOM. Our result also agree with the decrease in colon crypts reported by the activity of constituents of the juice, such as naringenin, naringin, quercetin, rutin, kaempferol, and lycopene (Wargovich et al, 2000;Vanamala et al, 2006;Warren et al, 2009;Leonardi et al, 2010;Nirmala and Ramanathan, 2011a). These results suggest that the observed precarcinogenic prevention by GJ could be related with a synergistic effect exerted by several of its components.…”

“…In several of the above mentioned chemopreventive studies with grapefruit or its components, authors have observed modifications on activities of compounds such as phosphatidylinositol 3-kinase, or the proinflammatory mediators cyclooxigenase (COX-1 and COX-2), as well as on the inducible nitric oxide synthase proteins. In some cases, these determinations were positively correlated with the capacity of the tested chemopreventive agent for :http://dx.doi.org/10.7314/APJCP.2013.14.11.6851 Grapefruit Juice Suppresses AOM-induced Colon ACF and Chemical carcinogenesis of the colon is a multistep process where persistent oxidative stress may lead to DNA damage, mutation of cancer related genes, besides the epigenetic silencing of tumor suppressor genes, proliferative increase, inflammation and apoptotic tissue damage (Klaunig and Kamendulis, 2004;Khan and Sultana, 2011;Nirmala and Ramanathan, 2011a). In the present report, we demonstrated a significant reduction by GJ on the level of lipid and protein oxidation induced by AOM, suggesting that the antioxidant capacity of the juice is involved in the carcinogenic prevention.…”

“…In fact, the antioxidant potential of GJ, as well as of various constituents has been clearly established in a number of tests, although only two of them has been carried out ex vivo (Alvarez-González et al, 2004;Gorinstein et al, 2005;Sengupta et al, 2006;Ademosun and Oboh, 2012). Also, a relationship between antioxidation and colon crypt inhibition has been documented in studies measuring lipoperoxidation, as well as enzymatic and non-enzymatic compounds (Nirmala and Ramanathan 2011a;2011b;Khan and Sultana, 2011). These data clearly reveal that agents reducing oxidative stress are relevant for impeding the cascade of events in colon carcinogenesis.…”

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

“…There are numerous mechanisms of antioxidant substances as anticancer such as: by scavenging free radical [7] , by inducing antioxidant enzymes [8] , by modulating protein kinase and lipid kinase signaling pathway [9] , by inhibiting cyclooxygenase-2 (COX-2) enzymatic activity [10] , by affecting phytoestrogenic [11] , by influencing nuclear transcription factor NF-κB [12] , by inducting phase I or phase II metabolizing enzymes [13] , inducting cell cycle arrest [14] , and by inhibiting matrix metalloproteinases (MMP)-2 and MMP-9 [15] .…”

A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis

“…Because of their potent pharmacological activity, low toxicity and economic feasibility, investigation of the medicinal properties of plant has been performed [1] . Along with the nutritional value, plants contribute in the protection from free radical deterioration by hindrance of lipid peroxidation via numerous mechanisms including scavenging free radicals [2] , inducing antioxidant enzymes [3] , modulating protein kinase, and lipid kinase signaling pathway [4] , inhibiting cyclooxygenase-2 (COX 2) and matrix metalloproteinases (MMP 2 and MMP 9) enzymatic activity [5,6] , influencing phytoestrogenic and nuclear transcription factor NF-κB [7,8] , inducing cell cycle arrest and phase 1 or phase 2 metabolizing enzymes [9,10] . Oxidative damage done by free radicals causes the pathogenesis of many deadly diseases like cancer, Alzheimer's and diabetes [11] .…”