Effect of Ligation of Pancreatic Ducts on the Serum Phosphatase

Nothmann, M.

doi:10.3181/00379727-57-14679

Cited by 13 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alkaline phosphatase is secreted into the pancreatic juice of the dog (Nothmann, 1944) and man (Warnes, Hine, and Kay, 1969), and ligation of the pancreatic ducts in the dog results in a progressive rise in the serum alkaline phosphatase of pancreatic origin (Nothmann, 1944). Nothmann further suggested that the level of serum alkaline phosphatase might be used as a diagnostic aid in pancreatic diseases, especially in those producing duct occlusion.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic alkaline phosphatase and a tumour variant

Warnes¹,

Timperley²,

Hine³

et al. 1972

Gut

View full text Add to dashboard Cite

SUMMARY Alkaline phosphatase has been extracted from human pancreas with n-butanol and has been shown to have distinctive isoenzyme characteristics when compared with the enzymes of small intestine and of normal serum. The enzyme has been demonstrated histochemically in a carcinoma of the pancreas and also in an islet cell tumour and the tumour enzyme has been shown to be unique, not only electrophoretically, but in being remarkably heat sensitive and in being activated by low molarities of urea.

show abstract

Section: Discussionmentioning

confidence: 99%

Pancreatic alkaline phosphatase and a tumour variant

Warnes¹,

Timperley²,

Hine³

et al. 1972

Gut

View full text Add to dashboard Cite

show abstract

“…It is also known that in some species alkaline phosphatase is secreted into pancreatic juice (Nothmann, 1944). Infusion of fatty acids releases alkaline phosphatase from human duodenal mucosa: this effect may be due to an alteration of membrane permeability, since, although small amounts of sucrase are liberated, no dipeptidase is released, which makes lysis of small-intestinal epithelium unlikely (Linscheer, Pihl, Wehr, and Fishman, 1970).…”

mentioning

confidence: 99%

The action of secretin and pancreozymin on small-intestinal alkaline phosphatase

Warnes¹,

Hine²,

Kay³

1974

Gut

View full text Add to dashboard Cite

SUMMARYThe hormones secretin and cholecystokinin-pancreozymin (CCK) have been shown to release brush-border alkaline phosphatase into the small-intestinal lumen in the human subject.In contrast to the disaccharidases, large amounts of alkaline phosphatase are present in human duodenal juice. The range has been established in normal subjects. Following the intravenous administration of both secretin and CCK-pancreozymin there is a large rise in the output of alkaline phosphatase in human duodenal juice. These rises are also present in patients with complete obstruction of the common bile and pancreatic ducts, and since the pancreatic juice of man contains negligible amounts of alkaline phosphatase, it is clear that both hormones must cause small-intestinal alkaline phosphatase to be released into duodenal juice. The isoenzyme characteristics of bile, smallintestinal, and pancreatic alkaline phosphatase have been established, and isoenzyme studies used to confirm this new action of secretin and CCK-pancreozymin.

show abstract