Effect of liraglutide on microcirculation in rat model with absolute insulin deficiency

Иванов, А. Н.; Lagutina, Daria D.; Saveleva, Mariia; Popyhova, Era B.; Stepanova, Tatyana; Savkina, Angelina A.; Pylaev, Timofey; Кузнецова, Наталья Александровна

doi:10.1016/j.mvr.2021.104206

Cited by 4 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that administration of liraglutide leads to the correction of microcirculation in rats with the absolute insulin deficiency. 37 The beneficial effects on cell function are regulated by the GLP‐1R axis.…”

Section: Discussionmentioning

confidence: 99%

Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model

Zhu

et al. 2023

JAHA

View full text Add to dashboard Cite

Background Severe hindlimb ischemia is a chronic disease with poor prognosis that can lead to amputation or even death. This study aimed to assess the therapeutic effect of liraglutide on hind‐limb ischemia in type 2 diabetic mice and to elucidate the underlying mechanism. Methods and Results Blood flow reperfusion and capillary densities after treatment with liraglutide or vehicle were evaluated in a mouse model of lower‐limb ischemia in a normal background or a background of streptozotocin‐induced diabetes. The proliferation, migration, and tube formation of human umbilical vein endothelial cells were analyzed in vitro upon treatment with liraglutide under normal‐glucose and high‐glucose conditions. Levels of phospho‐Akt, phospho‐endothelial nitric oxide synthase, and phospho‐extracellular signal‐related kinases 1 and 2 under different conditions in human umbilical vein endothelial cells and in ischemic muscle were determined by western blotting. Liraglutide significantly improved perfusion recovery and capillary density in both nondiabetic and diabetic mice. Liraglutide also promoted, in a concentration‐dependent manner, the proliferation, migration, and tube formation of normal glucose– and high glucose–treated human umbilical vein endothelial cells, as well as the phosphorylation of Akt, endothelial nitric oxide synthase, and extracellular signal‐related kinases 1 and 2 both in vitro and in vivo. The liraglutide antagonist exendin (9–39) reversed the promoting effects of liraglutide on human umbilical vein endothelial cell functions. Furthermore, exendin (9–39), LY294002, and PD98059 blocked the liraglutide‐induced activation of Akt/endothelial nitric oxide synthase and extracellular signal‐related kinases 1 and 2 signaling pathways. Conclusions These studies identified a novel role of liraglutide in modulating ischemia‐induced angiogenesis, possibly through effects on endothelial cell function and activation of Akt/endothelial nitric oxide synthase and extracellular signal‐related kinases 1 and 2 signaling, and suggested the glucagon‐like peptide‐1 receptor may be an important therapeutic target in diabetic hind‐limb ischemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model

Zhu

et al. 2023

JAHA

View full text Add to dashboard Cite

show abstract

“…Терапия лираглутидом в дозе 0.4 mg/kg/day вызывала повышение M на 40% по отношению к животным группы сравнения (таблица). Таким образом, экспериментально показано положительное влияние лираглутида на нейрогенный компонент сосудистого тонуса, что согласуется с ранее полученными данными, представленными в работе [5]. Установлено, что при диетиндуцированном ожирении лираглутид восстанавливает нарушенную эндотелий-зависимую дилатацию сосудов МЦ русла, оказывая, таким образом, эндотелиопротекторный эффект (таблица).…”

Section: результаты и обсуждениеunclassified

“…Это аналог глюкагоноподобного пептида-1 (ГПП-1, GLP-1), который способен ингибировать перистальтику желудка и снижать скорость его опорожнения [4], вследствие чего происходит уменьшение потребления пищи и снижение массы тела. Также показано положительное влияние лираглутида на микроциркуляцию (МЦ) при экспериментальном сахарном диабете [5]. Доказано, что ожирение способствует возникновению и развитию сердечно-сосудистых заболеваний (ССЗ), поэтому исследователи уделяют повышенное внимание изучению причинно-следственных связей между ожирением и нарушением функции МЦ сосудов.…”

Section: Introductionunclassified

Метод Лазерной Допплеровской Флоуметрии В Оценке Влияния Лираглутида На Микроциркуляцию У Крыс С Диет-Индуцированным Ожирением

Попыхова,

Пылаев,

Абрамов

et al. 2023

Оптика И Спектроскопия

View full text Add to dashboard Cite

The state of the microcirculatory bed in rats with obesity caused by the "cafeteria diet" was studied using laser Doppler flowmetry during therapy with liraglutide. It has been shown that obesity causes a decrease in the perfusion index and normalized amplitudes of endothelial and neurogenic oscillations on the skin of the dorsal foot of experimental animals. Therapy with liraglutide contributed to the reduction of excess body weight and the Lee index, which resulted in the restoration of disturbed microcirculation of the skin of the dorsal foot of rats, as well as the normalization of the functional activity of target organs.

show abstract

Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs

Lin,

Liu,

Hou

et al. 2024

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Effect of liraglutide on microcirculation in rat model with absolute insulin deficiency

Cited by 4 publications

References 28 publications

Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model

Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model

Метод Лазерной Допплеровской Флоуметрии В Оценке Влияния Лираглутида На Микроциркуляцию У Крыс С Диет-Индуцированным Ожирением

Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs

Contact Info

Product

Resources

About