Effect of liver‐protecting Sempervivum tectorum extract on the immune reactivity of spleen cells in hyperlipidaemic rats

Abstract

The pathobiological role of free radicals was demonstrated in hyperlipidaemia and in steatotic liver as well as in the immune response of lymphocytes and monocytes. Hyperlipidaemia has a suppressive effect on cellular immune responses, inhibits the mitogen induced lymphoblast transformation, diminishes the tumour necrosis factor alpha (TNF-a) production of spleen macrophages and enhances spontaneous interleukin 1 (IL-1) activity. A freeze dried extract of Semperuiuum tectorum has antioxidant, free radical scavenger and membrane stabilizing effects. The measured serum parameters were changed favourably after Sempetviuum tectorum extract treatment. The beneficial effect of Semperuiuum tectorum extract was also observed on the Con A stimulated blast transformation of splenocytes, on the lipopolysaccharide (LPS) triggered TNF-a activity and on the spontaneous IL-1 activity of spleen macrophages of hyperlipidaemic rats. The natural scavenger capacity was increased by treatment, initiating restoration of liver function.

Comparative screening of the anti-oxidant and antimicrobial activities of Sempervivum marmoreum L. extracts obtained by various extraction techniques

“…1 The genus Sempervivum contains about 50 species which occur predominantly in rocky places and at higher altitudes. 3,5,6 Polyphenols are present in 4.2 %, flavonoids in 0.70 % and polysaccharides in 11.2 %. The earliest publications concerning the therapeutic use of this drug deal with its influence on pharingitis, tracheitis, thrush, combustion and otitis.…”

Antinociceptive activity of Sempervivum tectorum L. extract in rats

“…However, 1000 mg/kg relieved the hyperalgesia suggesting a relatively low therapeutic index of the extract. It has been demonstrated that the lyophilized extract has antioxidant, free radical scavenger and membrane-stabilizing effects (Kéry et al, 1992(Kéry et al, , 1993Blázovics et al, 1994Blázovics et al, , 2000. The antiinflammatory profiles of other bioflavonoids, e.g.…”

Regulation of Herbal Medicine in Hungary

“…Luminometric methods suitable for routine examinations have also been developed in humans [15][16][17]. In our animal experiments, biochemical, immunological and quantitative analytical studies were supplemented with morphological studies [3,18,19].…”

“…In our experiments, several plant extracts of natural origin, such as Raphanus sativus niger, Sempervivum tectorum Cichorium intibus, Taraxacum officinale, Helichrysum arenarium, Peroselium crispum, Anthriscus cerefolium lyophilized extracts, Solidago canadensis and alcoholic and aqueous extracts of Ginkgo biloba . Hibiscus sabdariffa , Beta vulgaris var rubra as well as silibinin and silymarin compounds or fruits, apples sour cherries were investigated [7,12,18,19,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] .…”