Effect of &lt;i&gt;Bridelia ferruginea&lt;/i&gt; (Euphorbiaceae) Leaf Extract on Sucrose-induced Glucose Intolerance in Rats

Njamen, Dieudonné; Nkeh-Chungag, Benedicta N.; Tsala, Emmanuel; Fomum, Zacharias Tanee; Mbanya, Jean Claude; Ngufor, George

doi:10.4314/tjpr.v11i5.9

Cited by 9 publications

(13 citation statements)

References 20 publications

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“…Bridelia ferruginea Benth. (Phyllanthaceae), a popular plant species found in the Savannah regions or rain forests of Africa [ 1 ], growing as a twisted shrub that occasionally reaches the size of a tree, is greatly used in ethnomedicine for treating various ailments in different parts of Africa [ 2 ]. In fact, B. ferruginea is the best studied species of the genus Bridelia, and its traditional uses as natural remedies have been extensively documented.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant

et al. 2021

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To avail the possible pharmacological actions of Brideliaferruginea Benth., the present investigation was designed to quantitatively analyze the total flavonoid and phenolic contents and assess the various antioxidant and enzyme inhibition properties of leaf and stem bark extracts (ethyl acetate, water and methanolic) of B. ferruginea. Anti-proliferative effect was also investigated against human colon cancer cells (HCT116) as well as the antimicrobial potential against multiple bacterial and fungal (yeasts and dermatophytes) strains. The methanolic and water extracts of the stem bark demonstrated the highest phenolic content (193.58 ± 0.98 and 187.84 ± 1.88 mg/g, respectively), while the leaf extracts showed comparatively higher flavonoid contents (24.37–42.31 mg/g). Overall, the methanolic extracts were found to possess the most significant antioxidant potency. Compared to the other extracts, methanolic extracts of the B. ferruginea were revealed to be most potent inhibitors of acetyl- and butyryl-cholinesterases, tyrosinase α-amylase, except α-glucosidase. Only the ethyl acetate extracts were found to inhibit glucosidase. Additionally, the stem bark methanolic extract also showed potent inhibitory activity against E. coli and gram-positive bacteria (MIC (minimum inhibitory concentration): 2.48–62.99 µg/mL), as well as all the tested fungi (MIC: 4.96–62.99 µg/mL). In conclusion, B. ferruginea can be regarded as a promising source of bioactive compounds displaying multifunctional pharmacological activities and thus is a potential candidate for further investigations in the endeavor to develop botanical formulations for pharmaceutical and cosmeceutical industries.

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Section: Introductionmentioning

confidence: 99%

“…Nevertheless, tea prepared from the pulped bark is employed against fevers, stiffness, headaches, and as a local application for the treatment of oedemas [ 5 ]. Additionally, B. ferruginea bark extract is traditionally known to be used as a mouth wash, milk coagulant, vermifuge, and purgative [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant

et al. 2021

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“…The use of these medicinal plants, however, is not devoid of danger to health and exposes users to the risk of toxicity as well as unwanted side effects (Sonhi, 2002 ; Hilaly et al ., 2004 ; Maïga et al ., 2005 ). Bridelia ferruginea Benth (Euphorbiaceae) is a woody shrub that grows in the Savannah or rain forests of Africa (Njamen et al ., 2012 ) and is traditionally used to treat diabetes (Onunkwo et al ., 1996 ), arthritis (Olajide et al ., 2007 ) and boils (Talla et al ., 2002 ). The aqueous extract of the stem-bark of this plant contains quinones, gallic and catechic tannins, alkaloids, sterols, polyterpenes, polyphenols, reducing compounds, flavonoids and saponosides (Nene-Bi et al ., 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Toxicological evaluation of the aqueous stem bark extract of Bridelia ferruginea (Euphorbiaceae) in rodents

Awodele

Amagon

Agbo

et al. 2015

Interdisciplinary Toxicology

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Bridelia ferruginea is a woody shrub that grows in the Savannah or rain forests of Africa and has traditionally been used to treat diabetes, arthritis and boils. Despite all these uses, extensive toxicological evaluation has not been carried out. The aim of the present investigation was to evaluate the sub-chronic toxicological effects of the stem bark aqueous extract of Bridelia ferruginea in rats. The lethal dose (LD50) was determined using probit analysis and graded doses of the extract (250–4000 mg/kg) were administered to the animals via oral and intraperitoneal routes and observed for mortality, behavioral changes and signs of toxicity. Sub-chronic toxicity study was carried out at doses of 1 000, 2 000 and 4 000 mg/kg administered daily for 60 days. The animals were sacrificed after 60 days. Blood was collected for biochemical (renal and hepatic), hematological, oxidative stress, sperm and histopathological examinations, using standard methods. LD50 of the extract was estimated as >4 000 mg/kg orally; neither significant visible signs of toxicity nor mortality were observed. There were no significant differences in the animals and organ weights, hematological and biochemical parameters in the treated groups compared to the control group. However, a significant increase (p<0.05) in the level of lipid peroxidation and a significant (p<0.05) decrease in sperm count were observed in the treated animals compared with the control group. The stem-bark aqueous extract of Bridelia ferruginea was found to be relatively safe, though it has the potential to cause lipid peroxidation and damage sperm quality and should thus be used with caution.

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“…Extraction was done with sufficient quantity of 70 % ethanol with intermittent stirring for three weeks. The mixture was filtered and the supernatant evaporated using a rotary evaporator (R-210 Germany) [9].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Cinnamomum tamala Extract on Gentamicin-Induced Nephrotic Damage in Rabbits

Ullah¹,

Khan²,

Khan³

et al. 2013

Trop. J. Pharm Res

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Effect of <i>Bridelia ferruginea</i> (Euphorbiaceae) Leaf Extract on Sucrose-induced Glucose Intolerance in Rats

Cited by 9 publications

References 20 publications

Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant

Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant

Toxicological evaluation of the aqueous stem bark extract of Bridelia ferruginea (Euphorbiaceae) in rodents

Protective Effect of Cinnamomum tamala Extract on Gentamicin-Induced Nephrotic Damage in Rabbits

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