Protective Effect of Cinnamomum tamala Extract on Gentamicin-Induced Nephrotic Damage in Rabbits

Ullah, Naveed; Khan, Mir Azam; Khan, Taous; Ahmad, Waqar

doi:10.4314/tjpr.v12i2.13

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Histological changes accompained by gentamicin treatment vary from renal tubular epithelium cell necrosis, necrotizing glomeruli and atrophic of glomeruli. These results showed agreement with (47,48,49). Researchers have shown that gentamicin caused apoptosis in glomeruli and tubules in which gentamicin led to a significantly increased in the amount of cleaved caspase 3, Bax, and p53 protein expression while it decreased the Bcl-2 protein expression (50).…”

Section: Discussionsupporting

confidence: 88%

Role of Olive leaves Zinc Oxide Nanoparticles in Alleviating The Molecular and Histological Changes of Kidney in Female Goats-Induced by Gentamicin (Part III)

et al. 2020

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This study aimed to investigate the protective influence of olive leave extract zinc oxidenanoparticles (OLEZnONPs) complex against gentamicin–induced kidney dysfunctions ingoats. Twenty five adult female goats were randomly divided into five equal groups andtreated as follows: control group (C) administered sterile distilled water (IM) for 10 days,group G administered 25 mg/kg BW gentamicin (IM) for 7 days, group Z administered 10μg/kg BW of OLEZnONPs (IP) for 3 days, group GTZ administered 25 mg/kg BW gentamicin(IM) for 7 days and then 10 μg/kg BW of OLEZnONPs (IP) for 3 days, group GWZadministered 25 mg/kg BW gentamicin (IM) and 10 μg/kg BW of OLEZnONPs (IP) togetherfor first 3 days and then followed by gentamicin only for 4 days. After seven days of theexperiment, the gene expression of kidney injury molcule-1(KIM-1) and neutrophilgelatinase-association lipocalin (NGAL) gene expression of kidney tissue were measured. Inaddition, samples of kidney were obtained for histopathological examination. Gentamicinmedication induced a marked elevation in kidney tissue KIM-1 and NGAL gene expressionin G and GTZ groups compared to control and other groups. Intraperitoneal treatment ofgoats with OLEZnONPs did not significantly affect NGAL and KIM-1 gene expression in Z,GWZ, and control groups. Histologically, in contrast to control, gentamicin induced moreextensive kidney damages such as necrotized glomeruli, atrophic glomeruli, and renaltubular epithelial necrosis, while it was found that these alterations in kidney tissues wereimproved in goats given OLEZnONPs with gentamicin compared to group G. In conclusion,our results demonstrate that OLEZnONPs reduce the deleterious effects of gentamicin withsignificantly decreasing of KIM-1 and NGAL gene expression and remodeling the histologicalchanges of kidney in goats

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Section: Discussionsupporting

confidence: 88%

Role of Olive leaves Zinc Oxide Nanoparticles in Alleviating The Molecular and Histological Changes of Kidney in Female Goats-Induced by Gentamicin (Part III)

et al. 2020

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“…of rat. While Ullah et al 30 also found co-supplementation of cinnamon plus gentamicin at highest concentration improved the kidney profile in rats and suggested antioxidant effects of cinnamon are due to the presence of the copious amount of phenolic and flavonoid contents. Several recent studies have described a direct relationship between the oxidant stress induced by toxins or metal nanoparticles and its characterization by determination of the activity of oxidative stress-related biomarkers (MDA, LPO, CAT, and GSH).…”

Section: Discussionmentioning

confidence: 97%

Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats

et al. 2020

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Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can ameliorate NPs-associated pathophysiologies. The present study examined Cinnamomum cassia ( C. cassia) bark extracts (CMBE) for its ameliorative activity against Ni-NPs-induced pathophysiological and histopathological alterations in male Sprague Dawley rats. The biochemical analyses revealed that dosing rats with Ni-NPs at 10 mg/kg/body weight (b.w.) significantly altered the normal structural and biochemical adaptations in the liver and kidney. Conversely, supplementations with CMBE at different doses (225, 200, and 175 mg/kg/b.w. of rat) ameliorated the altered blood biochemistry and reduced the biomarkers of liver and kidney function considerably ( p < 0.05) in a dose-dependent manner. However, the best results were at 225 mg/kg/b.w. of rat. The study provided preliminary information about the protective effect of C. cassia against Ni-NPs indicated liver and kidney damages. Future investigations are needed to explore C. cassia mechanism of action of C. cassia and isolation of single constituents of C. cassia to assess their pharmaceutical importance accordingly.

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“…GM is a commonly used antibiotic aminoglycoside that has been shown to cause significant histological harm, particularly in renal proximal convoluted tubules. (46), (47) and (48). Extensive and major lesions of the renal system including tubular necrosis and inflammatory cell infiltration (49), shrinkage of the glomeruli, dilated and congested intertubular blood vessels and haemorrhage Vol.…”

Section: Effect Of Gentamicin and Ethanolic Extract Of Petroselinum Cmentioning

confidence: 99%

Ameliorative Effect of Ethanolic Extract of Petroselinum Crispum Against Gentamicin-Induced Nephrotoxicity in Rabbits Male

Hussain¹,

Kadhem²

2020

AJVS

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The experiment was conducted to investigate the protective effect of Petroselinum crispum leave extracted against gentamicin-induced nephrotoxicity in male rabbits by studying the body weight, clinical signs, haematological and biochemical parameters, gross lesion and histopathological changes. Twenty four rabbits male were used and divided into 4 groups. Group 1: rabbits served as a negative control, received distilled water 1 ml(orally). Group 2: rabbits served as a positive control group, received gentamicin at a dose of 80 mg/kg/day intramuscular for 15 days. Group 3: rabbits received gentamicin at a dose of 80 mg/kg/day then after one hour treated with ethanolic extract of Petroselinum crispum at dose 125 mg/kg orally for 15 days. Group 4: rabbits received gentamicin at a dose of 80 mg/kg/day then after one hour treated with ethanolic extract of Petroselinum crispum at dose 250 mg/kg orally for 15 days.The results of the gentamicin treated group( positive control group) showed clinical signs such as loss of body weight, loss of appetite and rough hair with hematuria. The body weight a significantly declined (p≤ 0.05) compared other groups. There was a significant decrease (p≤ 0.05) in WBC count, lymphocyte, GSH, SOD, CAT, and GPX levels, while it recorded a significant increase (p≤0.05) in weights of the kidneys, neutrophils, creatinine, urea, and MDA. Histological studies showed several kidney pathological changes such as pale colour, enlargement in size and weight and easy from detaching as opposed to negative control group. On the other hand, the group treated with ethanolic extractof Petroselinum crispum at dose 125 mg/kg induced improved of parameters as recorded significant increased(P ≤ 0.05) in body weight, WBC count, lymphocyte, GSH, SOD, CAT, and GPX, while significant decreased (P ≤ 0.05) in weights of the kidneys, neutrophils, creatinine, urea, and MDA compared with the positive control group whereas rabbits treated with ethanolic extract of Petroselinum crispum at dose 250 mg/kg restored the parameters and histological changes of the kidney to near normal status compared with the negative control group. These results showed that the dose-detected Petroselinum crispum extract (250mg / kg) acts as potential curative effect against gentamicin-induced nephrotoxicity in male rabbits.

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Protective Effect of Cinnamomum tamala Extract on Gentamicin-Induced Nephrotic Damage in Rabbits

Cited by 5 publications

References 13 publications

Role of Olive leaves Zinc Oxide Nanoparticles in Alleviating The Molecular and Histological Changes of Kidney in Female Goats-Induced by Gentamicin (Part III)

Role of Olive leaves Zinc Oxide Nanoparticles in Alleviating The Molecular and Histological Changes of Kidney in Female Goats-Induced by Gentamicin (Part III)

Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley rats

Ameliorative Effect of Ethanolic Extract of Petroselinum Crispum Against Gentamicin-Induced Nephrotoxicity in Rabbits Male

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