Effect of Magnesium on the Mechanical and Bioactive Properties of Biphasic Calcium Phosphate

Kanchana, P.; Sekar, C.

doi:10.4236/jmmce.2012.1110099

Cited by 9 publications

(14 citation statements)

References 26 publications

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“…The ability of HA to form the Liesegang rings (LRs) under slow and controlled conditions in agar matrix can be used as a simplified model system for simulation of the growth in human body. [ 21,22 ]…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing

Eltantawy

Belokon

Belogub³

et al. 2021

Advanced NanoBiomed Research

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A novel method of 3D self‐organization of patterns made of biomimetic hydroxyapatite (HA) in agar matrix is reported. The model system involves gradual ion diffusion and phase transitions of calcium phosphates. Herein, HA is precipitated for the first time in the agar gel matrix via single‐diffusion gel growth technique to aggregate the inorganic Liesegang rings (LRs). These patterns are formed as periodic structures through precipitation reaction and arise during the reagent diffusion in a polymer matrix. The concentrations of these inner and outer electrolytes, as well as pH and temperature effects on the morphologies, periodicity, stability, and number of LRs, are studied. In this study, the periodic HA Liesegang ring structures (HA LRs) are fabricated via a diffusion‐limited aggregation process. These patterns influence the C2C12 cell growth and allow to obtain the patterns formed by the cell tissue. This method can be prospective for the generation of 3D gradients in materials/3D gradient materials generation for studying the interface tissue engineering, systematic cell–biomaterial interaction, as well as for the fabrication of the stimuli‐responsive gradients to control/mimic migration of cells during the wound healing.

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Section: Introductionmentioning

confidence: 99%

Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing

Eltantawy

Belokon

Belogub³

et al. 2021

Advanced NanoBiomed Research

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“…[ 15 ] On the other hand, calcium phosphate-based ceramics can resemble the mineral phase, and as a consequence, these ceramics are bioactive, osteoconductive, and suitable for bone repair. [ 16 ] Biphasic calcium phosphate (BCP) ceramics contains a diverse amount of hydroxylapatite (HA), (Ca 10 [PO 4 ] 6 [OH] 2 ) and β-tricalcium phosphate (β-TCP [Ca3[PO4]2]). [ 17 ] HA is a bioactive ceramic which is a poorly soluble material whereas TCP is highly soluble which helps to increase the degradation rate of cements.…”

Section: Introductionmentioning

confidence: 99%

Poly (methyl methacrylate)/biphasic calcium phosphate/nano graphene bone cement for orthopedic application

Pahlevanzadeh

Ebrahimian-Hosseinabadi

2019

J Med Signals Sens

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Background:The aim of this study was to make a bioactive bone cement based on poly (methyl methacrylate) (PMMA) with suitable mechanical properties.Methods:PMMA has been modified by fabricating a composite consisting of biphasic calcium phosphate (BCP) 68 wt%, PMMA 31 wt% and graphene (Gr) 1 wt% (PMMA/BCP/Gr), 32 wt% of PMMA, and 68 wt% of BCP (PMMA/BCP) and pure PMMA by milling, mixing with monomer liquid, and casting. The modified cements were evaluated regarding mechanical properties, bioactivity, degradation rate, and biocompatibility.Results:The scanning electron microscopy (SEM) images of hydroxyapatite (HA) formed on samples surface after 28 days of immersion in simulated body fluid (SBF) demonstrated that bioactivity was obtained due to the addition of BCP, and the degradation rate of the cement was enhanced as well. Investigations of mechanical properties revealed that BCP increased the elastic modulus of PMMA more than 1.5 times, but predictably decreased elongation. The addition of 1 wt% Gr increased elongation and yield strength from 16.39% ± 1.02% and 61.67 ± 1.52 Mpa for PMMA/BCP to 35.18% ± 2.42% and 78.40 ± 2.06 Mpa for PMMA/BCP/Gr, respectively. MG63 cells survival and proliferation improved from 127.55% ± 7.03% for PMMA to 201.41% ± 10.7% for PMMA/BCP/Gr on Day 4 of culture.Conclusion:According to the obtained results of mechanical and biological tests, it seems that new PMMA/BCP/Gr bone cement has a potentiality for usage in orthopedic applications.

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“…[3,10] Besides, it also influences the apatite crystallization, promoting the formation of BTCP. [13] The presence of Na in biological apatites plays an important role in the cell adhesion and also in bone metabolism and resorption processes. [3] Trace Zn amounts favor osteoblastic cell proliferation and differentiation, adding a potent and selective inhibitory effect on osteoclastic bone resorption in vitro.…”

Section: Introductionmentioning

confidence: 99%

“…Mg substitution has its own significance in the calcification process and on bone fragility and has an indirect influence on mineral metabolism . Besides, it also influences the apatite crystallization, promoting the formation of BTCP . The presence of Na in biological apatites plays an important role in the cell adhesion and also in bone metabolism and resorption processes .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules

et al. 2017

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A route based on calcium phosphate emulsions with addition of glycolic acid as pore former was developed for synthesizing porous nanocrystalline biphasic calcium phosphate ceramics. The method is low cost and gives a biphasic calcium phosphate composed of 88% β-tricalcium phosphate and 12% hydroxyapatite. The material obtained is characterized by scanning electron microscopy, X-ray diffraction and X-ray fluorescence techniques, and the specific surface area is determined by the Brunauer, Emmett and Teller method. The small crystalline domain sizes obtained (68 and 87 nm for β-tricalcium phosphate and hydroxyapatite phases, respectively) allow a major contact reaction and stability in the interphase between the implanted material and natural bone, as well as a better promotion effect on the early bone in-growth. The improvement of the physical, chemical and structural properties by the balanced combination of the ceramic phases, the small crystallite size, the high porosity and high specific surface area obtained is a desirable characteristic in bone tissue engineering and encourages the performance of animal studies in vivo to evaluate their use for applications such as bone replacement in humans.

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Effect of Magnesium on the Mechanical and Bioactive Properties of Biphasic Calcium Phosphate

Cited by 9 publications

References 26 publications

Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing

Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing

Poly (methyl methacrylate)/biphasic calcium phosphate/nano graphene bone cement for orthopedic application

Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules

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