Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules

Garcés-Villalá, Miguel Ángel; Guirado, José Luiz Calvo; Granados, Dolly; Limandri, Silvina P.; Josa, V. Galván

doi:10.1002/xrs.2762

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…The placement of iodoformed gauze as a filler for the bone defect facilitates healing by second intention and is inexpensive but optimal bone rehabilitation is not achieved. To improve bone regeneration in large cysts and tumors, new low-cost bone grafts are currently being developed to fill in extensive bone defects after surgery [23] [24].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Central Giant Cell Granuloma with Carnoy’s Solution

Garcés-Villalá¹,

Rico²,

Escudero-Pinel³

et al. 2020

JBM

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A 25-year-old woman presented a unilateral mandibular swelling, after laboratory analysis, radiological studies and aspiration puncture biopsy, the pathological diagnosis of Central Giant Cell Granuloma was made. Radiographically, the multilocular lesion involved the left lower first molar and was 30 mm long by 20 mm high. Dental extraction of the molar involved with forceps and exeresis in toto of the tumor were performed using a Volkmann cutting curette. The tumor made up of 90% vascular tissue produced intra-surgical bleeding that made visibility difficult. The bone bed curettage was aggressive except for its base in direct contact with the inferior dental nerve. Subsequently, to avoid recurrence, the surgical protocol includes a double irrigation with Carnoy's solution, (fixative composed of 60% ethanol, 30% chloroform and 10% glacial acetic acid 98%) for 5 minutes that produces chemical cauterization. Finally, it was washed with physiological solution and the cavity was filled with iodoformed gauze. The gauze was exchanged and removed gradually over three weeks for second intention healing. This case is presented to demonstrate that inexpensive chemical treatment can be safely used for outpatient surgery under local anesthesia. Because Carnoy's solution achieved control of intraoperative bleeding, allowed bone healing and prevented recurrence of the lesion in clinical radiographic follow-up for 15 years.

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Central Giant Cell Granuloma with Carnoy’s Solution

Garcés-Villalá¹,

Rico²,

Escudero-Pinel³

et al. 2020

JBM

View full text Add to dashboard Cite

show abstract

“…Compared with the micrometric structure, nanosized bioceramics can more accurately mimic the hierarchical and nanoscale characteristics of bone and have higher biocompatibility. , Recently, the preparation methods and osteoinductivity of BCP nanoparticles have been studied extensively. − Especially, Liu et al used a mechanochemical method to prepare nanoscale BCP, and the particle size ranged from 20 to 60 nm . Therefore, the molecular simulation should be close to the nanoscale.…”

Section: Computational Detailsmentioning

confidence: 99%

Molecular Dynamics Simulation of Biomimetic Biphasic Calcium Phosphate Nanoparticles

et al. 2022

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Biphasic calcium phosphate (BCP) is used as a bone substitute and bone tissue repair material due to its better control over bioactivity and biodegradability. It is crucial to stabilize the implanted biomaterial while promoting bone ingrowth. However, a lack of standard experimental and theoretical protocols to characterize the physicochemical properties of BCP limits the optimization of its composition and properties. Computational simulations can help us better to learn BCP at a nanoscale level. Here, the Voronoi tessellation method was combined with simulated annealing molecular dynamics to construct BCP nanoparticle models of different sizes, which were used to understand the physicochemical properties of BCP (e.g., melting point, infrared spectrum, and mechanical properties). We observed a ∼20 to 30 Å layer of calcium-deficient hydroxyapatite at the HAP/β-TCP interface due to particle migration, which may contribute to BCP stability. The BCP model may stimulate further research into BCP ceramics and multiphasic ceramics. Moreover, our study may facilitate the optimization of compositions of BCP-based biomaterials.

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Preliminary Studies on Graphene-Reinforced 3D Products Obtained by the One-Stage Sacrificial Template Method for Bone Reconstruction Applications

Mocanu

Miculescu

Stan

et al. 2021

JFB

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The bone remodeling field has shifted focus towards the delineation of products with two main critical attributes: internal architectures capable to promote fast cell colonization and good mechanical performance. In this paper, Luffa-fibers and graphene nanoplatelets were proposed as porogen template and mechanical reinforcing agent, respectively, in view of framing 3D products by a one-stage polymer-free process. The ceramic matrix was prepared through a reproducible technology, developed for the conversion of marble resources into calcium phosphates (CaP) powders. After the graphene incorporation (by mechanical and ultrasonication mixing) into the CaP matrix, and Luffa-fibers addition, the samples were evaluated in both as-admixed and thermally-treated form (compact/porous products) by complementary structural, morphological, and compositional techniques. The results confirmed the benefits of the two agents’ addition upon the compact products’ micro-porosity and the global mechanical features, inferred by compressive strength and elastic modulus determinations. For the porous products, overall optimal results were obtained at a graphene amount of <1 wt.%. Further, no influence of graphene on fibers’ ability to generate at high temperatures internal interconnected-channels-arrays was depicted. Moreover, its incorporation led to a general preservation of structural composition and stability for both the as-admixed and thermally-treated products. The developed CaP-reinforced structures sustain the premises for prospective non- and load-bearing biomedical applications.

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Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules

Cited by 4 publications

References 32 publications

Surgical Treatment of Central Giant Cell Granuloma with Carnoy’s Solution

Surgical Treatment of Central Giant Cell Granuloma with Carnoy’s Solution

Molecular Dynamics Simulation of Biomimetic Biphasic Calcium Phosphate Nanoparticles

Preliminary Studies on Graphene-Reinforced 3D Products Obtained by the One-Stage Sacrificial Template Method for Bone Reconstruction Applications

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