Effect of Marlubium vulgare Plant on Experimentally Infected Albino Mice with Trichomonas muris Parasite and Compare with Metronidazole Drug

Abstract

This study was conducted to investigate the effect of Marlubium vulgare plant on albino mice experimentally infected with Trichomonas muris parasite and compared it with Metronidazole drug. The oral administration method was used to estimate the effect of the plant extract. where each group of mice was administered a different concentration of the plant alcoholic extract (500, 1500, 2500, 3500) mg/kg, and 30 mg/kg of metronidazole drug was administered to another group, while the control group was administered an equal amount of normal saline solution. The results showed a significant effect of the concentrations of alcoholic extract and the drug metronidazole in the treatment of infected albino mice and showed a high treatment efficiency of 100% with a variation in the time required for complete treatment and complete elimination of parasites. The highest concentration of 3500 mg/kg resulted in complete recovery in the affected albino mice on the fourth day after treatment, while the use of the drug led to a complete recovery on the fifth day after treatment, while the infection in the control group continued to the fifth day and then died. The conclusion of this study confirmed the high therapeutic efficacy of different concentrations of alcoholic extract of M. vulgare plant in treating T. muris parasite in mice experimentally infected with it, which is comparable to the effectiveness of Metronidazole drug.

Effect of Alcoholic Extract of Carrichtera annua Plant on the Growth of Leishmania donovani Parasite, In vitro Study

“…IOP Publishing doi:10.1088/1755-1315/1325/1/012027 2 Due to the resistance of the Leishmania parasite to many chemical treatments and also because of the high toxicity of these treatments, which harm human health, therefore medicinal plants and herbs were used as an alternative to these treatments, which is characterized by being safe to use and highly effective in eliminating pathogens, including parasites, because it contains many active substances [8]. Al-Khashin or Carrichtera annua plant belongs to the Cruciferae (Brassicaceae) and it is an annual herb with upward and densely branched stems, with a height ranging between 15-30 cm, it spreads in the slopes, valleys, hillsides, and roadsides, the plant grows in all types of soils [9], it blooms in mid-March to early May, the alcoholic extract of the plant has a superior ability to treat leishmaniasis, and its most important compounds are glycosides [10].…”

Effect of Alcoholic Extract of the Plant Conyza bonariensis on the Parasite Hymenolepis nana in Albino Mice Infected with it Experimentally

“…Research has tended at present to use herbs and medicinal plants in the treatment of various diseases, including parasitic diseases because they contain many effective compounds such as flavones, titanates, terpenes, alkaloids, glycosides, phenols, volatile oils, and others [7]. Which can interact with each other without the occurrence of any side effects on the patient's health when compared to the effects caused by medicines and chemical drugs [8]. Conyza bonariensis is a useful medicinal plant that belongs to the Compositae family (Asteraceae), it is a perennial herb with a single, standing stem, and its height ranges between 15-60 cm.…”