Effect of maternal zinc deficiency on offspring health: The epigenetic impact

Sanusi, Kamaldeen Olalekan; Ibrahim, Kasimu Ghandi; Abubakar, Bilyaminu; Malami, Ibrahim; Bello, Muhammad Bashir; Imam, Mustapha Umar; Abubakar, Murtala Bello

doi:10.1016/j.jtemb.2021.126731

Cited by 12 publications

(10 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, Zn may also modify epigenomic alterations carried out in fetal development, particularly in the generation of critical metabolites such as methionine and SAM, which carry out roles in DNA methylation. The generation of these metabolites relies on methyltransferases in which Zn acts as a cofactor in transferring methyl groups to homocysteine ( Uriu-Adams and Keen, 2010 ; Sanusi et al, 2021 ). The epigenetic modifications may, in turn, affect the expression and function of synaptic proteins.…”

Section: Discussionmentioning

confidence: 99%

The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Stanton

Malijauskaite

McGourty

et al. 2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Metal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer’s disease, Parkinson’s disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have considered the links between other “omes,” which may together result in an individual’s specific pathologies. In particular, ASD have been reported to have multitudes of possible causal effects. Metallomics data focusing on metal deficiencies and dyshomeostasis can be linked to functions of metalloenzymes, metal transporters, and transcription factors, thus affecting the proteome and transcriptome. Furthermore, recent studies in ASD have emphasized the gut-brain axis, with alterations in the microbiome being linked to changes in the metabolome and inflammatory processes. However, the microbiome and other “omes” are heavily influenced by the metallome. Thus, here, we will summarize the known implications of a changed metallome for other “omes” in the body in the context of “omics” studies in ASD. We will highlight possible connections and propose a model that may explain the so far independently reported pathologies in ASD.

show abstract

Section: Discussionmentioning

confidence: 99%

The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Stanton

Malijauskaite

McGourty

et al. 2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Zinc deficiency during the prenatal period and childhood can contribute to altered promoter methylation, causing immune system dysregulation that can lead to the development of chronic inflammatory diseases. Because of the importance of zinc in the function of epigenetic enzymes, studies suggest that zinc deficiency may interfere with biological activities related to epigenetic mechanisms in offspring [198,199]. In their experiments, Li et al investigated the effects of adequate or excessive maternal zinc intake on offspring intestinal immunity and basic epigenetic mechanisms in broiler chickens.…”

Section: Microbiota Epigenetics and Zincmentioning

confidence: 99%

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Ferenc,

Sokal-Dembowska,

Helma

et al. 2024

IJMS

View full text Add to dashboard Cite

The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in the human body. Existing evidence suggests that nutrients can influence the modulation of the gut microbiota. However, there is still limited evidence regarding the effects of vitamin and mineral supplementation on the human gut microbiota through epigenetic modification. It is plausible that maintaining an adequate dietary intake of vitamin D, iron, fibre, zinc and magnesium may have a beneficial effect on alleviating inflammation in the body, reducing oxidative stress, and improving the condition of the intestinal microbiota through various epigenetic mechanisms. Moreover, epigenetics involves alterations in the phenotype of a cell without changing its fundamental DNA sequence. It appears that the modulation of the microbiota by various nutrients may lead to epigenetic regulation. The correlations between microbiota and epigenetics are potentially interdependent. Therefore, the primary objective of this review is to identify the complex relationships between diet, gut microbiota, and epigenetic regulation. These interactions could play a crucial role in systemic health.

show abstract

“…Zn directly affects the physiology and action of insulin (115), the regulation of cytokine expression, the suppression of inflammation, and the activation of antioxidant enzymes (116). Zn is important in the functions of epigenetic enzymes; thus, lack of Zn may disrupt the bioactivities through epigenetics mechanisms (117). Zn can also increase glucose transport into cells and potentiate insulin-induced glucose transport to moderate glucose and lipid metabolism (118).…”

Section: Zincmentioning

confidence: 99%

The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

Zhang

Xiao

2021

Front. Nutr.

View full text Add to dashboard Cite

Diabetes has become the most common metabolic disease around the world. In addition to genetic and environmental factors in adulthood, the early life environment is critical to the progression of diabetes in adults, especially the environment during the fetal period; this concept is called “fetal programming.” Substantial evidence has illustrated the key role of early life macronutrient in programming metabolic diseases. Recently, the effect of maternal micronutrient intake on offspring glucose metabolism during later life has become an emerging field. This review focuses on updated human and animal evidence about the effect of maternal micronutrient status on offspring glucose metabolism and the underlying mechanism.

show abstract

Effect of maternal zinc deficiency on offspring health: The epigenetic impact

Cited by 12 publications

References 114 publications

The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

Contact Info

Product

Resources

About