The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

Wu, Yifan; Zhang, Qian; Xiao, Xinhua

doi:10.3389/fnut.2021.763809

Cited by 7 publications

(5 citation statements)

References 163 publications

(165 reference statements)

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“…The availability of maternal nutrients has a direct impact on fetal growth. 1 Fuel sources have an important role in energy balance, as well as cellular and physiological processes. This may play a key role in regulating active food intake after conception in growing embryos.…”

Section: Introductionmentioning

confidence: 99%

“…This may play a key role in regulating active food intake after conception in growing embryos. 1 , 2 Although all physiological processes necessitate energy during development, the thrifty hypothesis of developmental programming postulates that intrauterine exposure to unfavorable environments, such as excess nutrients, contributes to the pathophysiology of metabolic diseases later in life. 3 Energy fuel can be found in the form of sugar (glucose) and fat (triacylglycerides (TAGs)).…”

Section: Introductionmentioning

confidence: 99%

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Excess glucose or fat differentially affects metabolism and appetite-related gene expression during zebrafish embryogenesis

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Excess glucose or fat differentially affects metabolism and appetite-related gene expression during zebrafish embryogenesis

et al. 2023

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“…Third, previous research on offspring adiposity and prenatal diet has primarily focused on individual macronutrients 12 and micronutrients, 13 or pre-specified dietary quality indices, such as glycemic index 14 or the Mediterranean diet. 15 Data-driven techniques that identify naturally occurring diet patterns may offer a more comprehensive picture of prenatal diet.…”

Section: Introductionmentioning

confidence: 99%

“…11 Moreover, studies have demonstrated sex differences in measures of total body fat (i.e., BMI and body fat percentage), peripheral and central fat during the progression of puberty. 11 Third, previous research on offspring adiposity and prenatal diet has primarily focused on individual macronutrients 12 and micronutrients, 13 or pre-specified dietary quality indices, such as glycemic index 14 or the Mediterranean diet. 15 Data-driven techniques that identify naturally occurring diet patterns may offer a more comprehensive picture of prenatal diet.…”

Section: Introductionmentioning

confidence: 99%

Prenatal dietary patterns in relation to adolescent offspring adiposity and adipokines in a Mexico City cohort

Fossee

Zamora

Peterson

et al. 2023

J Dev Orig Health Dis

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Maternal diet during pregnancy has been associated with obesity among offspring. The extent to which trimester-specific dietary patterns are associated with markers of adiposity during adolescence remains unclear. We examined associations between prenatal diet patterns with adolescent offspring measures of adiposity and adipokines in 384 mother–adolescent dyads from the Mexico City ELEMENT cohort. Trimester-specific diet patterns were derived from principal component analysis of food frequency questionnaire data. Adolescent anthropometry and serum leptin and adiponectin were measured at 10–17 years. Three maternal diet patterns were identified: Prudent Diet (PD), high in fish and vegetables, the High Meat and Fat Diet (HMFD), high in pork and processed meats, and the Transitioning Mexican Diet (TMD), high in corn tortillas and sugar-sweetened beverages. Multiple linear regression was used to estimate sex-stratified associations among quartiles of diet patterns with adiposity and adipokines, adjusting for maternal marital status, education, and parity. First trimester TMD was associated with greater anthropometric measures and higher leptin in females, while third trimester HMFD was associated higher body fat percentage, triceps thickness, waist circumference, and leptin, but lower adiponectin among males. Contrary to expectation, there were positive associations between the trimester 1 PD pattern and anthropometric measurements in females, and for trimester 2 HMFD and TMD patterns with adipokines among males. Findings suggest maternal diet patterns may influence offspring adiposity markers during adolescence in a sex-specific manner.

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“…Maternal nutrition could be considered as a major factor in the intrauterine environment, and this is known as fetal programming [ 4 ]. Furthermore, it has been established that maternal nutrition during different stages of pregnancy can induce permanent changes in the metabolism of the future offspring [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal calcium propionate supplementation on offspring productivity and meat metabolomic profile in sheep

Pérez Segura,

Ramirez,

Relling

et al. 2023

PLoS ONE

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This study determined the effect of dietary calcium propionate (CaPr) as a source of energy supplementation during the First Half of Gestation (FMG), the Second Half of Gestation (SMG), and during All Gestation (AG), on offspring post-weaning growth performance, meat quality, and meat metabolomic profile. Thirty-one pregnant ewes were assigned to one of four treatments: a) supplementation of 30 gd−1 of CaPr during the first half of gestation (day 1 to day 75, n = 8) (FMG); b) supplementation of 30 gd−1 of CaPr during the second half of gestation (day 76 to day 150, n = 8) (SMG); c) supplementation of 30 gd−1 of CaPr during all gestation (AG, n = 8); d) no CaPr supplementation (control; CS, n = 7). The ewes were ad libitum fed a basal diet based on oat hay and corn silage. Ewes were distributed in a completely randomized unbalanced design to four treatments. The FMG group had lower (P ≤ 0.05) birth weight and weaning weight than the CS group. However, the average daily gain was similar across all treatments. Empty body weight and FMG had lower values (P ≤ 0.05) than the other groups. Both FMG and AG had lower hot carcass weight (P ≤ 0.05) compared to CS, while CaPr treatments resulted in reduced hot carcass yield (P ≤ 0.05). Meat color and texture were similar among treatments. A principal component analysis between gestation stages showed a trend for separating CS and FMG from SMG and AG, and that was explained by 93.7% of the data variability (PC1 = 87.9% and PC2 = 5.8%). Regarding meat metabolomic profile, 23 compounds were positively correlated between all treatments. Only 2 were negatively correlated (eicosane and naphthalene 1,2,3); but tetradecanoic acid, hexadecane, undecane 5-methyl, (-)-alpha, hexadecenoic acid, octadecanoic acid, and octadecane had a highly significant correlation (P ≤ 0.05). Overall, dam supplementation with CaPr during different periods of gestation provoked changes in meat metabolites related to the biosynthesis of fatty acids in lambs without negative changes in lamb’s growth performance and carcass quality.

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The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field

Cited by 7 publications

References 163 publications

Excess glucose or fat differentially affects metabolism and appetite-related gene expression during zebrafish embryogenesis

Excess glucose or fat differentially affects metabolism and appetite-related gene expression during zebrafish embryogenesis

Prenatal dietary patterns in relation to adolescent offspring adiposity and adipokines in a Mexico City cohort

Effects of maternal calcium propionate supplementation on offspring productivity and meat metabolomic profile in sheep

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