Effect of Medium-Chain Fatty Acids-Containing Dietary Oil on Hepatic Fatty Acid Oxidation Enzyme Activity in Rats.

Effect of Randomly Interesterified Triacylglycerols Containing Medium- and Long-Chain Fatty Acids on Energy Expenditure and Hepatic Fatty Acid Metabolism in Rats

“…Fractions measuring fatty acid metabolism-related enzyme activities in rat liver were prepared as described previously, 11) except that about 6 g of each liver was homogenized. Carnitine palmitoyltransferase (CPT), acyl-CoA dehydrogenase (ACAD), acyl-CoA oxidase (ACO), fatty acid synthase (FAS), ATP-citrate lyase (ACL), and glucose-6-phosphate dehydrogenase (G6PDH) were measured with a spectrophotometer.…”

“…[6][7][8][9][10] Previous studies have suggested possible mechanisms for the effect of MLCT on body fat accumulation, including enhancement of diet-induced energy expenditure in humans 6) and activation of hepatic fatty acid oxidation in rats. 10,11) However, although MLCT contain only oneeighth the amount of MCFA found in MCT, the reasons MLCT cause significant lower body fat accumulation than LCT are still unclear. Furthermore, the relationship y To whom correspondence should be addressed.…”

Physiological Functions of iso-type Short-Chain Fatty Acid and Omega 3 Polyunsaturated Fatty Acids Containing Oil in Obese OLETF Rats

“…For example, feeding of a structured triglyceride, containing both medium-chain fatty acids and long-chain fatty acids in the same molecule, reduced body fat accumulation and increased postprandial hepatic β-oxidation of fatty acids compared with long-chain triglyceride in rats 20,21 . Additionaly, feeding of seal oil, in which EPA and DHA are mainly located in sn-1,3 positions of triglyceride, more effectively reduced plasma and liver triglyceride levels through the suppression of fatty acid synthesis than fi sh oil, in which EPA and DHA are mainly located in sn-2 position, in rats 22,23 .…”

Randomly Interesterified Triacylglycerol Containing Medium- and Long-Chain Fatty Acids Stimulates Fatty Acid Metabolism in White Adipose Tissue of Rats

“…MLCT contains about 13% MCFA and can readily replace LCT in the daily diet. Additionally, MLCT, compared with LCT, has been shown to cause significantly lower body fat accumulation not only in rats [10][11][12] but also in humans. 13) Our preceding study in rats suggested that the enhanced energy expenditure and MCFA oxidation that was achieved without activating de novo lipogenesis in the liver was at least responsible for the lower body fat accumulation in rats fed with MLCT.…”