Effect of melatonin on exosomal dynamics in bovine cumulus cells

Pournaghi, Marjaneh; Khodavirdilou, Rasa; Saadatlou, Mohammad Ali Ebrahimi; Nasimi, Fatemeh Sokouti; Yousefi, Soodabeh; Mobarak, Halimeh; Darabi, Masoud; Shahnazi, Vahideh; Rahbarghazi‬, Reza; Mahdipour, Mahdi

doi:10.1016/j.procbio.2021.03.008

Cited by 20 publications

(17 citation statements)

References 42 publications

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“…A recent publication has shown that exosomes of bone marrow MSCs pre‐conditioned with melatonin had benefits in MSCs via paracrine effects and improved their therapeutic efficacy on I/R induced acute renal failure 107 . In line with these observations, Pournaghi et al demonstrated that melatonin alters exosomal size and production in bovine granulosa cells in a dose‐dependent manner 108 . Liu and co‐workers examined a potential correlation between melatonin receptors and exocytosis.…”

Section: Melatonin: a Possible New Role In Mscs Communication?mentioning

confidence: 93%

Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery

Luchetti

Carloni

Nasoni

et al. 2022

Journal of Pineal Research

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Efficient cell-to-cell communication is essential for tissue development, homeostasis, and the maintenance of cellular functions after injury. Tunneling nanotubes (TNTs) have emerged as a new important method of cell-to-cell communication.TNTs are primarily established between stressed and unstressed cells and can transport a variety of cellular components. Mitochondria are important trafficked entities through TNTs. Transcellular mitochondria transfer permits the incorporation of healthy mitochondria into the endogenous network of recipient cells, changing the bioenergetic profile and other functional properties of the recipient and may allow the recipient cells to recuperate from apoptotic processes and return to a normal operating state. Mesenchymal cells (MSCs) can form TNTs and transfer mitochondria and other constituents to target cells. This occurs under both physiological and pathological conditions, leading to changes in cellular energy metabolism and functions. This review summarizes the newly described capacity of melatonin to improve mitochondrial fusion/fission dynamics and promote TNT formation. This new evidence suggests that melatonin's protective effects could be attributed to its ability to prevent mitochondrial damage in injured cells, reduce senescence, and promote anastasis, a natural cell recovery phenomenon that rescues cells from the brink of death. The modulation of these new routes of intercellular communication by melatonin could play a key role in increasing the therapeutic potential of MSCs.

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Section: Melatonin: a Possible New Role In Mscs Communication?mentioning

confidence: 93%

Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery

Luchetti

Carloni

Nasoni

et al. 2022

Journal of Pineal Research

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“…Under some circumstances, amphisomes fuse with the cell membrane and are redirected toward lysosomes leading to the formation of autophagolysosomes and a reduction of exosome delivery (Figure 5; Villarroya-Beltri et al, 2016). It was suggested that the expression of GTPases such as Rab27a and Rab27b was increased in cumulus cells after treatment with melatonin for 7 days (Pournaghi et al, 2021).…”

Section: Figure 5 |mentioning

confidence: 99%

“…However, the exact relevance of melatonin as to its activities, such as those conveyed by exosomes, remains unknown ( He et al, 2016 ). Based on our recent findings melatonin alters exosome size and production in bovine granulosa cells in a dose-dependent manner in which higher melatonin concentrations contribute to the elevated release of small-sized exosomes ( Pournaghi et al, 2021 ). This may be due to the promotion of ILVs formation and/or alterations of exosome physicochemical properties.…”

Section: Effect Of Melatonin On Exosome Biogenesis and Releasementioning

confidence: 99%

“…The report claimed a moderate rise in the synthesis of unsaturated fatty acids and sphingolipids upon treatment with melatonin, indicating an increase in membrane flexibility and fluidity ( Sunyer-Figueres et al, 2020 ). In our previous work, we found that melatonin can alter the unsaturated/saturated fatty acid ratio by increasing Arachidonic acid, Oleic acid, and Linoleic acid levels and change the flexibility of the cell membrane, leading to enhanced exosome delivery ( Pournaghi et al, 2021 ).…”

Section: Effect Of Melatonin On Exosome Biogenesis and Releasementioning

confidence: 99%

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An Examination of the Putative Role of Melatonin in Exosome Biogenesis

Amini

Rezabakhsh

Heidarzadeh

et al. 2021

Front. Cell Dev. Biol.

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During the last two decades, melatonin has been found to have pleiotropic effects via different mechanisms on its target cells. Data are abundant for some aspects of the signaling pathways within cells while other casual mechanisms have not been adequately addressed. From an evolutionary perspective, eukaryotic cells are equipped with a set of interrelated endomembrane systems consisting of intracellular organelles and secretory vesicles. Of these, exosomes are touted as cargo-laden secretory vesicles that originate from the endosomal multivesicular machinery which participate in a mutual cross-talk at different cellular interfaces. It has been documented that cells transfer various biomolecules and genetic elements through exosomes to sites remote from the original cell in a paracrine manner. Findings related to the molecular mechanisms between melatonin and exosomal biogenesis and cargo sorting are the subject of the current review. The clarification of the interplay between melatonin and exosome biogenesis and cargo sorting at the molecular level will help to define a cell’s secretion capacity. This review precisely addresses the role and potential significance of melatonin in determining the efflux capacity of cells via the exosomal pathway. Certain cells, for example, stem cells actively increase exosome efflux in response to melatonin treatment which accelerates tissue regeneration after transplantation into the injured sites.

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“…They can transfer different biomolecules such as lipids, proteins, and nucleic acids between different cells, distinguishing their significant role in cell-cell communications ( Raposo and Stoorvogel, 2013 ). EVs are generated and released by almost all types of cells and are classified as exosomes, macrovesicles, and apoptotic bodies ( Gurunathan et al, 2021 ; Pournaghi et al, 2021 ). Also, ectosomes, shedding vesicles, and microparticles are other types of EVs involved in inter/intra cellular communications ( Gurunathan et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases

et al. 2021

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Extracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles containing various cargoes including peptides, proteins, different types of RNAs and other nucleic acids, and lipids. These vesicles are produced by all cell types, in which stem cells are a potent source for them. Stem cell-derived EVs could be promising platforms for treatment of infectious diseases and early diagnosis. Infectious diseases are responsible for more than 11 million deaths annually. Highly transmissible nature of some microbes, such as newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), drives researcher’s interest to set up different strategies to develop novel therapeutic strategies. Recently, EVs-based diagnostic and therapeutic approaches have been launched and gaining momentum very fast. The efficiency of stem cell-derived EVs on treatment of clinical complications of different viruses and bacteria, such as SARS-CoV-2, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Staphylococcus aureus, Escherichia coli has been demonstrated. On the other hand, microbial pathogens are able to incorporate their components into their EVs. The microbe-derived EVs have different physiological and pathological impacts on the other organisms. In this review, we briefly discussed biogenesis and the fate of EVs. Then, EV-based therapy was described and recent developments in understanding the potential application of stem cell-derived EVs on pathogenic microorganisms were recapitulated. Furthermore, the mechanisms by which EVs were exploited to fight against infectious diseases were highlighted. Finally, the deriver challenges in translation of stem cell-derived EVs into the clinical arena were explored.

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Effect of melatonin on exosomal dynamics in bovine cumulus cells

Cited by 20 publications

References 42 publications

Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery

Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery

An Examination of the Putative Role of Melatonin in Exosome Biogenesis

Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial Diseases

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