Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens

Chen, Fuju; Reheman, Aikebaier; Cao, Jing; Wang, Zixu; Dong, Yulan; Zhang, Yu-Xian; Chen, Yaoxing

doi:10.1016/j.jphotobiol.2016.05.001

Cited by 32 publications

(41 citation statements)

References 33 publications

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“…A few studies investigating the light effects on immune response indicated that low level blue light did not induce toxicity to lymphocytes (Chen et al, 2016; Li et al, 2015). Phan et al reported that T lymphocytes possess intrinsic capacity to sense and respond to light, and this photosensitivity may enhance the motility of T cells in skin (Phan et al, 2016).…”

Section: Effect Of Antimicrobial Blue Light On Host Cells and Tissuesmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

227

192

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As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

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Section: Effect Of Antimicrobial Blue Light On Host Cells and Tissuesmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

227

192

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“…Melatonin also enhances the abundance of Ki67 and Bcl2 (protein makers for proliferation) in antigen‐specific T cells, which indicates that melatonin actively contributes to T‐cell proliferation . In vivo evidence from a study using broiler chickens showed that proliferation of T cells in their thymus is positively correlated with concentrations of melatonin in the plasma, while pinealectomy, which reduces melatonin levels in the blood, or the use of antagonists to MT1 decreases the proliferation of T cells . Direct evidence that melatonin activates T cells was provided by a study which demonstrated that inhibiting HIOMT in PHA‐activated Jurkat cells reduces production of melatonin and IL‐2 .…”

Section: Melatonin and Activation Of T Cellsmentioning

confidence: 99%

“…Direct evidence that melatonin activates T cells was provided by a study which demonstrated that inhibiting HIOMT in PHA‐activated Jurkat cells reduces production of melatonin and IL‐2 . Similarly, exogenous melatonin promotes the proliferative activity of T cells, while antagonists of MT1 limit their proliferation . Available evidence strongly indicates that melatonin increases the activation of T cells; however, the underlying mechanisms remain unknown.…”

Section: Melatonin and Activation Of T Cellsmentioning

confidence: 99%

“…108 In vivo evidence from a study using broiler chickens showed that proliferation of T cells in their thymus is positively correlated with concentrations of melatonin in the plasma, while pinealectomy, which reduces melatonin levels in the blood, or the use of antagonists to MT1 decreases the proliferation of T cells. 109 Direct evidence that melatonin activates T cells was provided by a study which demonstrated that inhibiting HIOMT in PHAactivated Jurkat cells reduces production of melatonin and IL-2. 110 Similarly, exogenous melatonin promotes the proliferative activity of T cells, while antagonists of MT1 limit their proliferation.…”

Section: Activation Of T Cellsmentioning

confidence: 99%

“…110 Similarly, exogenous melatonin promotes the proliferative activity of T cells, while antagonists of MT1 limit their proliferation. 109 Available evidence strongly indicates that melatonin increases the activation of T cells; however, the underlying mechanisms remain unknown.…”

Section: Activation Of T Cellsmentioning

confidence: 99%

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Melatonin signaling in T cells: Functions and applications

Ren

Liu

Chen

et al. 2017

Journal of Pineal Research

186

130

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Melatonin affects a variety of physiological processes including circadian rhythms, cellular redox status, and immune function. Importantly, melatonin significantly influences T-cell-mediated immune responses, which are crucial to protect mammals against cancers and infections, but are associated with pathogenesis of many autoimmune diseases. This review focuses on our current understanding of the significance of melatonin in T-cell biology and the beneficial effects of melatonin in T-cell response-based diseases. In addition to expressing both membrane and nuclear receptors for melatonin, T cells have the four enzymes required for the synthesis of melatonin and produce high levels of melatonin. Meanwhile, melatonin is highly effective in modulating T-cell activation and differentiation, especially for Th17 and Treg cells, and also memory T cells. Mechanistically, the influence of melatonin in T-cell biology is associated with membrane and nuclear receptors as well as receptorindependent pathways, for example, via calcineurin. Several cell signaling pathways, including ERK1/2-C/EBPα, are involved in the regulatory roles of melatonin in Tcell biology. Through modulation in T-cell responses, melatonin exerts beneficial effects in various inflammatory diseases, such as type 1 diabetes, systemic lupus erythematosus, and multiple sclerosis. These findings highlight the importance of melatonin signaling in T-cell fate determination, and T cell-based immune pathologies. K E Y W O R D Smelatonin, multiple sclerosis, systemic lupus erythematosus, T cells, Th17 cells, Treg cells

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Identification and postnatal developmental characteristics of brown adipose tissue in yak calves

Fuju,

Yutian,

Xiaodong

2024

Veterinary Medicine & Sci

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BackgroundBrown adipose tissue (BAT) provides newborn mammals with a critical capacity for non‐shivering thermogenesis and enables their adaptation to the cold of the extrauterine environment. The domestic yak (Bos grunniens) has evolved on the Qinghai–Tibet Plateau and has adapted well to extremely cold and hypoxic environments. However, the location, characterization and postnatal development of BAT in yak calves remain largely unknown.MethodsWe identified different types of adipocytes and explored the postnatal development of interscapular and subcutaneous adipose tissue in yak calves at 1, 7 and 30 days old using morphological and molecular biology methods.ResultsThe results show that multilocular and unilocular adipocytes were found in two depots. Multilocular adipocytes contained small lipid droplets packed with numerous mitochondria. However, unilocular adipocytes contained a single unilocular lipid droplet and few mitochondria. The number of multilocular adipocytes significantly decreased, whereas the number of unilocular adipocytes significantly increased from day 1 to 30. Furthermore, uncoupling protein 1 (UCP1) expressions in both multilocular and unilocular adipocytes, as well as UCP1 mRNA and protein expression, were significantly decreased from day 1 to 30. In addition, peroxisome proliferator‐activated receptor‐γ coactivator‐1α and peroxisome proliferator‐activated receptor alpha mRNA expression were significantly decreased.ConclusionsThe results of the research indicate that adipocytes in both newborn yak calf interscapular and subcutaneous adipose tissue are multilocular adipocytes. Many multilocular adipocytes were transformed into unilocular adipocytes after birth, but some multilocular adipocytes remained at day 30; this transition occurred at different rates in different depots. These results provide a basis for further study of BAT in yak calves.

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Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens

Cited by 32 publications

References 33 publications

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Melatonin signaling in T cells: Functions and applications

Identification and postnatal developmental characteristics of brown adipose tissue in yak calves

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