Effect of Mineral Trioxide Aggregate on Mesenchymal Stem Cells

D’Antò, Vincenzo; Caprio, Maria Patrizia Di; Ametrano, Gianluca; Simeone, Mariarosaria; Rengo, Sandro; Spagnuolo, Gianrico

doi:10.1016/j.joen.2010.08.010

Cited by 76 publications

(68 citation statements)

References 35 publications

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“…In the present study, the ability of iRoot BP Plus to support dental pulp repair through the promotion of cellular adhesion and migration of DPSCs was investigated. It has been demonstrated that MTA can accelerate the cellular migration of human bone marrowderived mesenchymal stem cells [31]. Our results present further evidence that MTA can enhance the cellular adhesion and migration of DPSCs in vitro.…”

Section: Discussionsupporting

confidence: 81%

In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair

et al. 2014

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Section: Discussionsupporting

confidence: 81%

In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair

et al. 2014

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“…Human mesenchymal stem cells (hMSC) showed excellent attachment and viability on CPC 33) , and MTA was able to assist hMSC adhesion, growth, and migration 34) . Although there are no published reports comparing the response of hMSC to the two materials, it may be expected that CPC has the same levels of biocompatibility as that of MTA to hMSC, besides osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

Effects of a calcium phosphate cement on mineralized nodule formation compared with endodontic cements

et al. 2012

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The aim of this study was to investigate mineralizing ability of a premixed calcium phosphate cement (premixed-CPC) compared to mineral trioxide aggregate (MTA) and zinc oxide eugenol cement (SuperEBA) in ROS17/2.8 cells. The measurements of cell proliferation, alkaline phosphatase (ALPase) activity and mineralized nodule formation in the presence or absence (control) of the test materials were performed using a cell culture insert method with the test materials placed on a porous membrane of culture plate insert. Mineralized nodules were detected by staining with alizarin red, and the calcium content of the mineralized nodules was determined quantitatively using a calcium assay kit. Premixed-CPC and MTA indicated significantly higher cell proliferation, ALPase activity, mineralized nodule formation, and calcium content in nodules than those of SuperEBA (p<0.05). The present results suggest that premixed-CPC has the same mineralizing ability as MTA.

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“…This observation is probably related to the ability of MTA to enhance cell migration. 12 In present case report also first case showed incomplete MTA apical plug, however, follow-up evaluation has shown healed periapical region with intact lamina dura. the root by external root resorption the non surgical approach followed for the management seemed predictable, however, long term follow up is necessary.…”

mentioning

confidence: 46%

Management of a non-vital immature tooth using MTA as an apical plug: Two case reports

2015

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MTA appears to be a valid option for apexification with its main advantage being, the speed at which the treatment can be completed. A major problem in performing endodontics in immature teeth with necrotic pulp and wide open apices is obtaining an optimal seal of the root-canal system. Mineral Trioxide Aggregate (MTA), has been proposed as a potential material to create an apical plug at the end of the root-canal system, thus preventing the extrusion of filling materials.

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Effect of Mineral Trioxide Aggregate on Mesenchymal Stem Cells

Cited by 76 publications

References 35 publications

In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair

In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair

Effects of a calcium phosphate cement on mineralized nodule formation compared with endodontic cements

Management of a non-vital immature tooth using MTA as an apical plug: Two case reports

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