Effect of Mixture Including Hot Water Extract of Houttuynia cordata Thunb on Ethanol-Induced Hangover in Rats

유양희,; 이현미,; 정창식,; 이민재,; 전우진,

doi:10.3746/jkfn.2016.45.10.1508

Cited by 8 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on the cytotoxicity test and acute model animal experiment results in this study, LF+AM could be used as safe material with similar efficacy. You et al [26] reported on the facilitation of blood alcohol and acetaldehyde by a mixture containing Houttuynia cordata, and it is surmised that the material developed in the present study showed efficacy similar to this.…”

Section: Mrnasupporting

confidence: 70%

Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study)

Pyun¹,

Seo²,

Kim

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Hepatic protective effects of Ligularia fischeri (LF) and Aronia melanocarpa (AM) against alcohol were investigated in vitro and in vivo test. LF, AM, and those composed mixing material (LF+AM) were treated in HepG2 cell. Alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly increased in each singleness extract and mixed composite. The protective effect on alcoholic liver damage was investigated by animal models. Serum alcohol level and acetaldehyde level were significantly decreased by LF+AM treatment in acute experimental model. In the chronic mouse model study, we had found that the increased plasma liver damage index (alkaline phosphatase) by alcohol treatment was declined by oral administration of LF+AM extraction composite. As well as, it was identified that the protection effect was induced by increasing catalase activity and suppressing COX-2, TNF-α, MCP-1, and IL-6 mRNA expressions. CYP2E1 mRNA expression was also increased. These results suggest that oral ingestion of LF and AM mixed composite is able to protect liver against alcohol-induced injury by increasing alcohol metabolism activity and antioxidant system along with decreasing inflammatory responses.

show abstract

Section: Mrnasupporting

confidence: 70%

Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study)

Pyun¹,

Seo²,

Kim

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Mice in all groups, except the normal group, were treated with ethanol. After 30 min of GBK or physiological saline administration, 2 mL/kg of 25% ethanol was orally administered [ 26 ]. Blood was collected from the hepatic portal vein 0.5, 1, and 2 h after oral administration of ethanol.…”

Section: Methodsmentioning

confidence: 99%

Hangover-Relieving Effect of Ginseng Berry Kombucha Fermented by Saccharomyces cerevisiae and Gluconobacter oxydans in Ethanol-Treated Cells and Mice Model

et al. 2023

View full text Add to dashboard Cite

This study aimed to evaluate the hangover relieving effect of ginseng berry kombucha (GBK) fermented with Saccharomyces cerevisiae and Gluconobacter oxydans in in vitro and in vivo models. The antioxidant activity and oxidative stress inhibitory effect of GBK were evaluated in ethanol-treated human liver HepG2 cells. In addition, biochemical and behavioral analyses of ethanol treated male ICR mice were performed to confirm the anti-hangover effect of GBK. The radical scavenging activity of GBK was increased by fermentation, and the total ginsenoside content of GBK was 70.24 μg/mL. In HepG2 cells, in which oxidative stress was induced using ethanol, GBK significantly increased the expression of antioxidant enzymes by upregulating the Nrf2/Keap1 pathway. Moreover, GBK (15 and 30 mg/kg) significantly reduced blood ethanol and acetaldehyde concentrations in ethanol-treated mice. GBK significantly increased the levels of alcohol-metabolizing enzymes, including alcohol dehydrogenase and acetaldehyde dehydrogenase. The balance beam test and elevated plus maze test revealed that high-dose GBK significantly ameliorated ethanol-induced behavioral changes. Collectively, GBK exerted a protective effect against ethanol-induced liver damage by regulating the Nrf2/Keap1 pathway.

show abstract

“…Extracts of Houttuynia cordata, Nelumbo nucifera G. leaf, and Camellia sinensis seed had ameliorating effect on hangover symptoms of intoxicated rats in the study of You et al In their study, blood ethanol and acetaldehyde in the rats treated by herbal extract were lower than their levels in the control group. In addition, the herbal-treated group showed an increased activity of liver ADH and ALDH, which helped in faster clearance of ethanol and acetaldehyde from the body (You et al, 2016) 173.20% for ALDH; . Similar study conducted by Noh et al (2009) found that Dandelion juice could increase the concentrations of plasma ALDH and expression of catalase and glutathione reductase in males aged 24-28 years.…”

Section: Herbal Medicinementioning

confidence: 96%

Detoxification activity of bioactive food compounds against ethanol‐induced injuries and hangover symptoms: A review

Moslemi

Jannat

Mahmoudzadeh

et al. 2023

Food Science & Nutrition

View full text Add to dashboard Cite

Alcohol drinking is a popular activity among adolescents in many countries, largely due to its pleasant, relaxing effects. As a major concern, ethanol consumption put the drinkers at risk of nutrients' deficiency due to the disordered eating, anorexia, and malabsorption of nutrients. Moreover, alcohol drinking may lead to the development of hangover symptoms including diarrhea, thirsty, fatigue, and oxidative stress. A broad range of functional food components with antioxidant and/or anti‐inflammatory properties including pectin, aloe vera polysaccharides, chito‐oligosaccharides, and other herbal components have been explored due to their detoxification effects against ethanol. The underlying anti‐hangover mechanisms include reducing the intestinal absorption of ethanol or its metabolites, increasing the activity of ethanol metabolizing enzymes, development of fatty acid β‐oxidation in mitochondria, inhibition of inflammatory response, blocking the target receptors of ethanol in the body, and possession of antioxidant activity under the oxidative stress developed by ethanol consumption. Therefore, the development of bioactive food‐based therapeutic formula can assist clinicians and also drinkers in the alleviation of alcohol side effects.

show abstract

Effect of Mixture Including Hot Water Extract of Houttuynia cordata Thunb on Ethanol-Induced Hangover in Rats

Cited by 8 publications

References 15 publications

Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study)

Protective Effects of Ligularia fischeri and Aronia melanocarpa Extracts on Alcoholic Liver Disease (In Vitro and In Vivo Study)

Hangover-Relieving Effect of Ginseng Berry Kombucha Fermented by Saccharomyces cerevisiae and Gluconobacter oxydans in Ethanol-Treated Cells and Mice Model

Detoxification activity of bioactive food compounds against ethanol‐induced injuries and hangover symptoms: A review

Contact Info

Product

Resources

About