Effect of Monensin on Feed Efficiency of Feedlot Cattle

Raun, A. P.; Cooley, C. O.; Potter, E. L.; Rathmacher, R. P.; Richardson, L. F.

doi:10.2527/jas1976.433670x

Cited by 188 publications

(92 citation statements)

References 9 publications

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“…2 and 54). It has also been used as a feed additive in agriculture, because of the anticoccidial activity and because it promotes the growth of several animal species that are used in that industry (55,56). FIG.…”

Section: Discussionmentioning

confidence: 99%

Monensin Mediates a Rapid and Selective Transport of Pb2+

Hamidinia¹,

Shimelis²,

Tan³

et al. 2002

Journal of Biological Chemistry

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The carboxylic acid ionophore monensin, known as an electroneutral Na ؉ ionophore, an anticoccidial agent, and a growth-promoting feed additive in agriculture, is shown to be highly efficient as an ionophore for Pb 2؉ and to be highly selective for Pb 2؉ compared with other divalent cations. Monensin transports Pb 2؉ by an electroneutral mechanism in which the complex PbMonOH is the transporting species. Electrogenic transport via the species PbMon ؉ may also be possible. Monensin catalyzed Pb 2؉ transport is little affected by Ca 2؉ , Mg 2؉ , or K ؉ concentrations that are encountered in living systems. Na ؉ is inhibitory, but its effectiveness at 100 mM does not exceed ϳ50%. The poor activity of monensin as an ionophore for divalent cations other than Pb 2؉ is consistent with the pattern of complex formation constants observed in the mixed solvent 80% methanol/water. This pattern also explains why Ca 2؉ , Mg 2؉ , and K ؉ are ineffective as inhibitors of Pb 2؉ transport, but it does not fully explain the actions of Na ؉ , where kinetic features of the transport mechanism may also be important. When given to rats at 100 ppm in feed together with Pb 2؉ at 100 ppm in drinking water, monensin reduces Pb accumulation in several organs and tissues. It also accelerates the excretion of Pb that was accumulated previously and produces this effect without depleting the organs of zinc or copper. Monensin, used alone or in combination with other agents, may be useful for the treatment of Pb intoxication.

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Section: Discussionmentioning

confidence: 99%

Monensin Mediates a Rapid and Selective Transport of Pb2+

Hamidinia¹,

Shimelis²,

Tan³

et al. 2002

Journal of Biological Chemistry

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“…Singh and Mohini (1999) reported the normal molar proportion of acetate, propionate and butyrate in cattle as 65.85±1.32, 24.33±0.99 and 9.97±0.86 respectively. Raun et al, (1976) also reported a shift towards more propionate after feeding the rumensin led to decrease in both acetate and butyrate. Blummel and Orskov (1993) found that in vitro gas production technique provides a reflection of amounts and proportions of VFA due to close correlation between the stoichiometry of short chain fatty acid (SCFA) within the rumen and the in vitro gas production.…”

Section: Volatile Fatty Acids (In Vitro)mentioning

confidence: 99%

Physiological Responses and In-Vitro Volatile Fatty Acid Production in Cattle

Rai¹,

Singh²,

Soren³

2017

Int.J.Curr.Microbiol.App.Sci

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“…The drug is of limited antibacterial activity but is used extensively as a feed additive to control coccidiosis in chickens and to stimulate growth in beef cattle [20,221. Experimentally, monensin has been shown to control coccidia in other animal species as well [ 141.…”

mentioning

confidence: 99%

Light and Electron Microscopic Changes in Cardiac and Skeletal Muscle of Sheep with Experimental Monensin Toxicosis

1983

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Abstract.Monensin toxicosis was induced in lambs by either a single oral dose of 12 mg/ kg or six daily doses of 8 mg/kg. Clinical signs of toxicosis consisted of depression, dyspnea, stiffness of gait, reluctance to move, and recumbency. Serum creatine phosphokinase activity was increased. Samples of skeletal and cardiac muscle were obtained over a six-day period and examined by light and electron microscopy. Light microscopic changes in cardiac and skeletal muscles consisted initially of vacuolation and intracellular edema of muscle cells followed by segmental necrosis. Interstitial fibrosis was present on days 5 and 6 postexposure. Muscle fiber necrosis was more severe in skeletal than cardiac muscles and most severe in sheep given 8 mg/kg of monensin daily. Macrophages were seen only in areas of severe necrosis. The earliest ultrastructural change was severe swelling of mitochondria. Secondary changes consisted of lipid accumulation and myofibrillar alterations. Myoblast proliferation was present as early as four days after initial exposure to monensin.

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Effect of Monensin on Feed Efficiency of Feedlot Cattle

Cited by 188 publications

References 9 publications

Monensin Mediates a Rapid and Selective Transport of Pb2+

Monensin Mediates a Rapid and Selective Transport of Pb2+

Physiological Responses and In-Vitro Volatile Fatty Acid Production in Cattle

Light and Electron Microscopic Changes in Cardiac and Skeletal Muscle of Sheep with Experimental Monensin Toxicosis

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