Effect of monordica charantia linn. Pomous aqueous extract on cataractogenesis in murrin alloxan diabetics

Srivastava, Y.; Venkatakrishna‐Bhatt, H.; Verma, Yogendra

doi:10.1016/s0031-6989(88)80041-9

Cited by 47 publications

(24 citation statements)

References 3 publications

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“…In alloxan-induced diabetic rats, blood glucose was decreased and cataract formation, a side effect of hyperglycemia, was delayed with oral administration of bitter melon (94). Acetone extract of bitter melon was reported to reduce blood glucose and cholesterol to normal range after 15-30 days administration.…”

Section: Hypoglycemic Effect Of Bitter Melon On Animal Modelsmentioning

confidence: 99%

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Yin¹,

Zhang²,

Ye³

2008

EMIDDT

339

220

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In management of metabolic syndrome, the traditional Chinese medicine (TCM) is an excellent representative in alternative and complementary medicines with a complete theory system and substantial herb remedies. In this article, basic principle of TCM is introduced and 22 traditional Chinese herbs are reviewed for their potential activities in the treatment of metabolic syndrome. Three herbs, ginseng, rhizoma coptidis (berberine, the major active compound) and bitter melon, were discussed in detail on their therapeutic potentials. Ginseng extracts made from root, rootlet, berry and leaf of Panax quinquefolium (American ginseng) and Panax ginseng (Asian ginseng), are proved for anti-hyperglycemia, insulin sensitization, islet protection, anti-obesity and anti-oxidation in many model systems. Energy expenditure is enhanced by ginseng through thermogenesis. Ginseng-specific saponins (ginsenosides) are considered as the major bioactive compounds for the metabolic activities of ginseng. Berberine from rhizoma coptidis is an oral hypoglycemic agent. It also has anti-obesity and anti-dyslipidemia activities. The action mechanism is related to inhibition of mitochondrial function, stimulation of glycolysis, activation of AMPK pathway, suppression of adipogenesis and induction of low-density lipoprotein (LDL) receptor expression. Bitter melon or bitter gourd (Momordica charantia) is able to reduce blood glucose and lipids in both normal and diabetic animals. It may also protect β cells, enhance insulin sensitivity and reduce oxidative stress. Although evidence from animals and humans consistently supports the therapeutic activities of ginseng, berberine and bitter melon, multi-center large-scale clinical trials have not been conducted to evaluate the efficacy and safety of these herbal medicines.Metabolic syndrome characterized by insulin resistance has become a health thread worldwide in the past 20 years (1). In survey of 8,814 people in USA, prevalence of metabolic syndrome was over 40% in people of 60-69 year old (2). In the other geographic areas in the world including Europe and Asia, the prevalence of metabolic syndrome has been increasing dramatically (1). Metabolic syndrome and associated diseases have been one of major burdens in health care system in many industrialized countries.The concept of metabolic syndrome was generated by Kylin in 1923, who described a cluster of medical conditions, such as hypertension, hyperglycemia and gout (3). The concept did not attract much attention until Dr. Gerald Reaven introduced the syndrome X in 1988 (4), which is similar to the metabolic syndrome. In 1999, WHO (World Health Organization) and EGIR (European Group for the Study of Insulin Resistance) released their diagnostic criteria for the metabolic syndrome, respectively (5;6). Now, there are at least 6 sets of diagnostic criteria for the syndrome from different organizations over the world (1;7). The primary contents of diagnostic criteria are similar among these organizations. They are hyperglycemia, insulin r...

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Section: Hypoglycemic Effect Of Bitter Melon On Animal Modelsmentioning

confidence: 99%

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Yin¹,

Zhang²,

Ye³

2008

EMIDDT

339

220

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“…[1][2][3][4][5][6][7] In a previous study, we reported that Momordica charantia decreased the blood glucose in genetically type 2 diabetic mice. An important type 2 diabetic cure is exercise therapy and diet.…”

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confidence: 99%

Suppressive Activity of the Fruit of Momordica charantia with Exercise on Blood Glucose in Type 2 Diabetic Mice

Miura

Itoh

Iwamoto

et al. 2004

Biological & Pharmaceutical Bulletin

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The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) with exercise was investigated in KKAy mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L. (MC) with exercise reduced the blood glucose of KK-Ay mice 5 weeks after oral administration (pϽ0.001), and also significantly lowered the plasma insulin of KK-Ay mice under similar conditions (pϽ0.01). The blood glucose of MC with exercise is lower than that of MC only or exercise only 5 weeks after the administration. MC with exercise decreased blood glucose in a glucose tolerance test. These results suggest that MC with exercise is useful for type 2 diabetic cure.

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“…Cataract is a long-term complication of diabetes, the only remedy for the treatment of such kind disease is surgery with undesirable defects. Several studies reported that oxidative stress and hyperglycemia have been suggested as common underlying mechanisms of cataractogenesis due to diabetes and augmentation of the antioxidant defenses of the lens have been shown to prevent or delay cataract [47,48]. Therefore, any strategy that prevents (or) slow down the progression of cataract can have a significant effect on human health.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Free Radical Scavenging Activity and in Vivo Anticataract Potential of Hemidesmus Indicus Roots in Streptozotocin Induced Diabetic Rats

Tirumani

2017

Asian J Pharm Clin Res

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Objective: Hemidesmus indicus R. Br. (HI) (Indian sarsaparilla) is traditionally used in Indian medicine for human therapy. The present study was aimed to evaluate the antioxidant activity of HI root extracts, and its effects on delaying (or) management of cataract progression in streptozoticin (STZ) induced diabetic rats. Methods:The plant roots were extracted in different solvents, estimated total phenolic content, total flavonoid content and conducted free radical scavenging potential through 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2 azinobis (3-ethyl benzothiazoline-6-sulphonic acid diammonium salt (ABTS) NO, OH and reducing power assays. Further, the protective effect was evaluated in STZ induced diabetic rats through administered of ethyl acetate extract of HI (200 and 400 mg/kg body weight) orally for 8 weeks to study its effect on oxidative stress and diabetic cataract progression. Results:In primary results demonstrated that the ethyl acetate extract has been showed considerable free radical scavenging activity and significantly gain body weight, gradual decreasing blood glucose levels and delay cataract progression has been observed in HI treated rats. Furthermore, we observed significantly decreased oxidative stress markers, and restoration of the antioxidant system in HI treated rats. Lens sections from experimental animal again evidenced to conform the ameliorative effect of HI on diabetic cataract. Conclusion:This obtained result's confirmed that the protective effect of HI is attributed to the antioxidant activities of plant roots and its active principles.

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Effect of monordica charantia linn. Pomous aqueous extract on cataractogenesis in murrin alloxan diabetics

Cited by 47 publications

References 3 publications

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Suppressive Activity of the Fruit of Momordica charantia with Exercise on Blood Glucose in Type 2 Diabetic Mice

In Vitro Free Radical Scavenging Activity and in Vivo Anticataract Potential of Hemidesmus Indicus Roots in Streptozotocin Induced Diabetic Rats

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