Effect of mushrooms on obesity in animal models: study protocol for a systematic review and meta-analysis

Grotto, Denise; Camargo, Isabella Ferreira; Kodaira, Kátia; Mazzei, Lauren Giustti; Castro, Juliana Brandão Pinto de; Vieira, Raquel Andrade Leite; Bergamaschi, Cristiane de Cásia; Lopes, Luciane Cruz

doi:10.1186/s13643-019-1205-3

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…[ 11 ] In recent years, whole food‐based approaches in preventing obesity have received increasing attentions. [ 12,13 ] Taken together, dietary intake of whole foods can positively regulate the gut microbiota and metabolites, thereby achieving an anti‐obesity effect.…”

Section: Introductionmentioning

confidence: 99%

Whole Agrocybe cylindracea Prevented Obesity Linking with Modification of Gut Microbiota and Associated Fecal Metabolites in High‐Fat Diet‐Fed Mice

Zhu

Huang

Liu

et al. 2022

Molecular Nutrition Food Res

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Scope: Whole-food-based strategies to prevent metabolic diseases are growing interests. Agrocybe cylindracea (AC) is a major edible mushroom with high values of nutrition, but little is known about its health benefits as a portion of whole food. Methods and Results: Diet-induced obese, C57BL/6J mice are fed an high-fat diet (HFD) with or without AC (3% or 5%, w/w in the diet) for 9 weeks. The results show that dietary AC reduced body weight, adipose accumulation, impairment of glucose tolerance, lipid levels, and liver injury in HFD-fed mice. Moreover, AC not only prevents HFD-induced gut disorder, as indicates by the enriched probiotic Bifidobacterium and reduced endotoxin-bearingProteobacteria, but also improve the lipopolysaccharide (LPS) level and gut tissue structure. Fecal metabolites such as harmine and harmanine are also remarkably altered by AC. Spearman's correlation analysis reveals that the AC-altered microbes and metabolites are strongly correlated with obesity-related indexes. Conclusion: These findings suggest that dietary AC prevents HFD-induced obesity and its complications in association with modulating gut microbiota and associated fecal metabolites.

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Section: Introductionmentioning

confidence: 99%

Whole Agrocybe cylindracea Prevented Obesity Linking with Modification of Gut Microbiota and Associated Fecal Metabolites in High‐Fat Diet‐Fed Mice

Zhu

Huang

Liu

et al. 2022

Molecular Nutrition Food Res

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“…Meta-analytical work also shows that mushroom intake could be inversely associated with cancer risk, particularly breast cancer [ 63 , 64 , 65 ]. It has been also been proposed that mushroom consumption could protect against obesity-related hypertension and dyslipidaemia, possibly by mediating antioxidant and anti-inflammatory pathways [ 66 , 67 ]. As well as possessing antioxidative, anti-inflammatory and immunomodulating activities, it is also thought that mushroom polysaccharides could act as prebiotics in the digestive system [ 68 ].…”

Section: Mycelium/fungal-derived Proteinsmentioning

confidence: 99%

Is There Scope for a Novel Mycelium Category of Proteins alongside Animals and Plants?

Derbyshire

2020

Foods

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In the 21st century, we face a troubling trilemma of expanding populations, planetary and public wellbeing. Given this, shifts from animal to plant food protein are gaining momentum and are an important part of reducing carbon emissions and consumptive water use. However, as this fast-pace of change sets in and begins to firmly embed itself within food-based dietary guidelines (FBDG) and food policies we must raise an important question—is now an opportunistic time to include other novel, nutritious and sustainable proteins within FBGD? The current paper describes how food proteins are typically categorised within FBDG and discusses how these could further evolve. Presently, food proteins tend to fall under the umbrella of being ‘animal-derived’ or ‘plant-based’ whilst other valuable proteins i.e., fungal-derived appear to be comparatively overlooked. A PubMed search of systematic reviews and meta-analytical studies published over the last 5 years shows an established body of evidence for animal-derived proteins (although some findings were less favourable), plant-based proteins and an expanding body of science for mycelium/fungal-derived proteins. Given this, along with elevated demands for alternative proteins there appears to be scope to introduce a ‘third’ protein category when compiling FBDG. This could fall under the potential heading of ‘fungal’ protein, with scope to include mycelium such as mycoprotein within this, for which the evidence-base is accruing.

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“…More serious cases of obesity are associated with an increasing incidence of diseases such as asthma, gallstones, steatohepatitis, glomerulosclerosis, dyslipidemia, and endothelial dysfunction [7]. The list of health consequences is extensive, and in addition to affecting quality of life, it also contributes to a higher risk of premature death [8]. In the last two decades, the need to develop new therapies increased significantly.…”

Section: Introductionmentioning

confidence: 99%

Murine Models of Obesity

et al. 2022

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Obesity, classified as an epidemic by the WHO, is a disease that continues to grow worldwide. Obesity results from abnormal or excessive accumulation of fat and usually leads to the development of other associated diseases, such as type 2 diabetes, hypertension, cancer, cardiovascular diseases, among others. In vitro and in vivo models have been crucial for studying the underlying mechanisms of obesity, discovering new therapeutic targets, and developing and validating new pharmacological therapies against obesity. Preclinical animal models of obesity comprise a variety of species: invertebrates, fishes, and mammals. However, small rodents are the most widely used due to their cost-effectiveness, physiology, and easy genetic manipulation. The induction of obesity in rats or mice can be achieved by the occurrence of spontaneous single-gene mutations or polygenic mutations, by genetic modifications, by surgical or chemical induction, and by ingestion of hypercaloric diets. In this review, we describe some of the most commonly used murine models in obesity research.

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Effect of mushrooms on obesity in animal models: study protocol for a systematic review and meta-analysis

Cited by 6 publications

References 30 publications

Whole Agrocybe cylindracea Prevented Obesity Linking with Modification of Gut Microbiota and Associated Fecal Metabolites in High‐Fat Diet‐Fed Mice

Whole Agrocybe cylindracea Prevented Obesity Linking with Modification of Gut Microbiota and Associated Fecal Metabolites in High‐Fat Diet‐Fed Mice

Is There Scope for a Novel Mycelium Category of Proteins alongside Animals and Plants?

Murine Models of Obesity

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