Effect of nano metal oxides on heme molecule: molecular and biomolecular approaches

doi:10.33263/briac101.837845

Cited by 8 publications

(3 citation statements)

References 40 publications

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“…Metal-based nanomaterials represent an attractive possibility for encapsulating and delivering bioactive molecules to the site of interest [37,38]. Particularized for reaching the place of an SCI lesion, gold has been noticed as the most investigated nanoscale metal.…”

Section: Metal-based Nanocarriersmentioning

confidence: 99%

Novel Strategies for Spinal Cord Regeneration

Costăchescu

Niculescu

Dabija

et al. 2022

IJMS

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A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord regeneration. In this respect, the present review aims to explore the most recent developments in SCI treatment and spinal cord repair. Specifically, it briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers (e.g., metal-based, polymer-based, liposomes) for spinal cord delivery, relevant biomolecules (e.g., growth factors, exosomes) for SCI treatment, innovative cell therapies, and novel natural and synthetic biomaterial scaffolds for spinal cord regeneration.

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Section: Metal-based Nanocarriersmentioning

confidence: 99%

Novel Strategies for Spinal Cord Regeneration

Costăchescu

Niculescu

Dabija

et al. 2022

IJMS

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“…Generally, nanotechnology always proves that it can control the assembling processes of different chemical structures at nanoscale materials [11]. Therefore, nanomaterials are often observed to emerge among the focus of advanced research [12,13].…”

Section: Introductionmentioning

confidence: 99%

Effect of hydrogenation of carbon atom on its deposition on graphene

et al. 2022

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This article discusses the possibility of graphene functionalization by the deposition of carbon atoms with different degrees of hydrogenation and the effect of hydrogenation on the probability of precipitation using computer simulation. According to the results of computer simulation, the binding energy of the single carbon atom, methine, methylene and methyl is more than 1 eV. This corresponds to chemisorption, which means that the chemical bonds are generated due to unpaired valent electrons of the incident particles and defect-free graphene. Methane does not have unpaired valent electrons and in the range of investigated deposition energies its chemisorption on graphene is not observed. The free carbon atom with various degrees of its hydrogenation is considered: methane CH, methylene CH 2 , methyl CH 3 and methane CH 4 . It is established that if the deposited particles C, CH, CH 2 and CH 3 form a bound state with graphene, these particles are located near the characteristic points with a different probability of location above graphene at these points. The processes of deposition of hydrogenated and non-hydrogenated carbon atoms with kinetic energies of 1.0, 1.2, 1.5, 2.3 and 3.1 eV on graphene are studied. It is found that the processes of deposition of non-hydrogenated and hydrogenated carbon atoms on defect-free graphene depend on the degree of hydrogenation of the carbon atom: the more hydrogenated the carbon atom is, the less its probability of chemisorption on graphene. Methane, as a fully hydrogenated carbon atom, does not chemisorb on graphene at deposition energies from 1 to 3.1 eV. It is also observed that the maximum probability of chemisorption of C, CH, CH 2 and CH 3 on graphene took place at deposition energy of about 2.3 eV.

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“…The cutting-edge advances in the field of nanostructures and nanotechnology found a broad field of applications in nanomedicine and pharmaceutical treatments, including antibacterial therapy [10][11][12][13]. Metal oxide nanoparticles are extensively studied as valuable alternatives to antibiotics due to a series of interesting characteristics such as proved antimicrobial activity, biocompatibility, lack of toxicity, and stability [14][15][16][17][18][19]. Among these, ZnO has been recognized as a safe food additive by the U.S. Food and Drug Administration (FDA) [20,21].…”

Section: Introductionmentioning

confidence: 99%

Biofilm-Resistant Nanocoatings Based on ZnO Nanoparticles and Linalool

et al. 2021

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Biofilms represent an increasing challenge in the medical practice worldwide, imposing a serious threat to public health. As bacterial strains have developed antibiotic resistance, researcher’s attention has been extensively focused on developing more efficient antimicrobial strategies. In this context, the present study reports the synthesis, physicochemical characterization, ex vivo biodistribution, and in vitro evaluation of the capacity of nanostructured surfaces based on zinc oxide (ZnO) and biologically active molecules to modulate clinically relevant microbial biofilms. ZnO nanoparticles (NPs) were synthesized through a co-precipitation method without thermal treatment. The matrix-assisted pulsed laser evaporation (MAPLE) was applied for preparing nanostructured coatings based on ZnO NPs surface modified with linalool that were further characterized by X-ray diffraction (XRD), thermogravimetric analysis with differential scanning calorimetry (TGA-DSC), scanning electron microscopy (SEM), transmission electron microscopy with selected area electron diffraction (TEM-SAED), Fourier-transform infrared spectroscopy (FT-IR), and infrared microscopy (IRM). Histological analyses carried out at 7 days and 14 days after the intraperitoneal administration of linalool modified ZnO NPs revealed the absence of the latter from the brain, kidney, liver, lung, myocardium, and pancreas. Through in vitro assays on prokaryotic cells, it was proven that ZnO coatings hinder microbial biofilm formation of both Gram-positive and Gram-negative bacteria strains.

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Effect of nano metal oxides on heme molecule: molecular and biomolecular approaches

Cited by 8 publications

References 40 publications

Novel Strategies for Spinal Cord Regeneration

Novel Strategies for Spinal Cord Regeneration

Effect of hydrogenation of carbon atom on its deposition on graphene

Biofilm-Resistant Nanocoatings Based on ZnO Nanoparticles and Linalool

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