Effect of nanofibrous porosity on the X-ray attenuation properties of electrospun n-Bi2O3/epoxy–polyvinyl alcohol (PVA) nanofiber mats

Abunahel, Bassam M.; Quffa, Khetam M.; Azman, Nurul Zahirah Noor

doi:10.1007/s00339-018-1975-9

Cited by 24 publications

(11 citation statements)

References 12 publications

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“…The needle (spinneret) diameter is also an important factor affecting the morphological properties of the electrospun nanofibers (Kuchi et al, 2018). At a constant flow rate, as the internal diameter of the needle decreases, so does the average diameter of the nanofiber (Abunahel et al, 2018). Furthermore, the porosity of the fiber improves when a spinneret with a smaller diameter is used.…”

Section: Principles Of Electrospinningmentioning

confidence: 99%

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

Pattnaik

Swain

Ramakrishna

2022

WIREs Nanomed Nanobiotechnol

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Poor aqueous solubility of both, existing drug molecules and those which are currently in the developmental stage, have posed a great challenge to pharmaceutical scientists because they often exhibit poor dissolution behavior and subsequent poor and erratic bioavailability. This has triggered extensive research to explore nanotechnology‐based technology platforms for possible rescue. Recently, nanofibers have been exploited widely for diverse biomedical applications including for drug delivery. Electrospun nanofibers are capable of preserving the homogeneously loaded therapeutic agents in amorphous state potentialy impairing devitrification. The present review aims at providing an overview of the various key factors that affect the electrospinning process and characteristics of the nanofibers while fabrication of drug loaded nanofibers for poorly soluble drug candidates. The review explores various methodological advancements in the electrospinning process and set‐ups for production scale‐up. The various types of electrospun nanofibers (like simple matrix, core‐sheath, Janus, and inclusion complex nanofibers) that have been exploited for the delivery of poorly soluble drugs are also critically assessed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Principles Of Electrospinningmentioning

confidence: 99%

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

Pattnaik

Swain

Ramakrishna

2022

WIREs Nanomed Nanobiotechnol

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“…It has been shown that thinner and defect-free fibers with higher porosity are obtained using needles with small diameters. [106,107] The morphology of the fibers as well as their alignment are dependent on the design of the collector, which can be chosen according to the final application. Randomly or ordered aligned fibers and 3D structured fibers can be obtained using different collectors: static, rotating mandrel, rotating wire drum, guide wires, rotating disk, liquid bath collector, among others.…”

Section: Process Parametersmentioning

confidence: 99%

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Costa

Fangueiro

Ferreira

2022

Macromolecular Bioscience

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Recently, photodynamic therapy (PDT) has become a promising approach for the treatment of a broad range of diseases, including oncological and infectious diseases. This minimally invasive and localized therapy is based on the production of reactive oxygen species able to destroy cancer cells and inactivate pathogens by combining the use of photosensitizers (PSs), light, and molecular oxygen. To overcome the drawbacks of drug systemic administration, drug delivery systems (DDS) can be used to carrier the PSs, allowing higher therapeutic efficacy and minimal toxicological effects. Polymeric nanofibers produced by electrospinning emerged as powerful platforms for drug delivery applications. Electrospun nanofibers exhibit outstanding characteristics, such as large surface‐area‐to‐volume ratio associated with high drug loading, high porosity, flexibility, ability to incorporate and release a wide variety of therapeutic agents, biocompatibility, and biodegradability. Due to the versatility of this technique, fibers with different morphologies and functionalities, including drug release profile can be produced. The possibility of scalability makes electrospinning even more attractive for the development of DDS. This review aims to explore and show an up to date of the huge potential of electrospun nanofibers as DDS for different PDT applications and discuss the opportunities and challenges in this field.

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“…With the emergence of nanotechnology as a progressive branch of science in recent years, various types of nanoparticles have been used to design radiation shields. The advantage of using nanomaterials in this field is that the distances between molecules are very small, increasing the possibility of photon collisions with atoms of the material, and thus improving the material's ability to attenuate photons [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Ceramics Based Red-Clay by Bulk and Nano Metal Oxides for Photon Shielding Features

et al. 2021

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We prepared red clays by introducing different percentages of PbO, Bi2O3, and CdO. In order to understand how the introduction of these oxides into red clay influences its attenuation ability, the mass attenuation coefficient of the clays was experimentally measured in a lab using an HPGe detector. The theoretical shielding capability of the material present was obtained using XCOM to verify the accuracy of the experimental results. We found that the experimental and theoretical values agree to a very high degree of precision. The effective atomic number (Zeff) of pure red clay, and red clay with the three metal oxides was determined. The pure red clay had the lowest Zeff of the tested samples, which means that introducing any of these three oxides into the clay will greatly enhance its Zeff, and consequently its attenuation capability. Additionally, the Zeff for red clay with 10 wt% CdO is lower than the Zeff of red clay with 10 wt% Bi2O3 and PbO. We also prepared red clay using 10 wt% CdO nanoparticles and compared its attenuation ability with the red clay prepared with 10 wt% PbO, Bi2O3, and CdO microparticles. We found that the MAC of the red clay with 10 wt% nano-CdO was higher than the MAC of the clay with microparticle samples. Accordingly, nanoparticles could be a useful way to enhance the shielding ability of current radiation shielding materials.

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Effect of nanofibrous porosity on the X-ray attenuation properties of electrospun n-Bi2O3/epoxy–polyvinyl alcohol (PVA) nanofiber mats

Cited by 24 publications

References 12 publications

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Enhancement of Ceramics Based Red-Clay by Bulk and Nano Metal Oxides for Photon Shielding Features

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