Effect of nanotubular-micro-roughened titanium surface on cell response in vitro and osseointegration in vivo

Yun, Kwi-Dug; Yang, Yunzhi; Lim, Hyun-Pil; Oh, Gye-Jeong; Koh, Jeong‐Tae; Bae, In-Ho; Kim, Jae-Hyung; Lee, Kwang-Min; Park, Sang-Won

doi:10.1016/j.msec.2009.08.004

Cited by 39 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The surface topography of the biomaterial is another factor that is important in osteoblastic spreading (21,24,26,27). Several studies have observed that bone cells spread and flattened with greater efficacy on nanostructured porous coatings, compared with rough coatings (21,36,37). However, contrary conclusions have been drawn in other studies (38,39), and, as a result, it has been difficult to establish a simple conclusion with regard to the correlation between the surface topography and osteoblastic spreading.…”

Section: Discussionmentioning

confidence: 99%

Integrin-mediated osteoblastic adhesion on a porous manganese-incorporated TiO2 coating prepared by plasma electrolytic oxidation

Zhang

Zhu

et al. 2013

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

This study was conducted to evaluate the bioactivity of manganese-incorporated TiO2 (Mn-TiO2) coating prepared on titanium (Ti) plate by plasma electrolytic oxidation (PEO) technique in Ca-, P- and Mn-containing electrolytes. The surface topography, phase and element compositions of the coatings were investigated using scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy dispersive spectrometry (EDS), respectively. The adhesion of osteoblast-like MG63 cells onto Ti, TiO2 and Mn-TiO2 surfaces was evaluated, and the signal transduction pathway involved was confirmed by the sequential expression of the genes for integrins β1, β3, α1 and α3, focal adhesion kinase (FAK), and the extracellular regulated kinases (ERKs), including ERK1 and ERK2. The results obtained indicated that Mn was successfully incorporated into the porous nanostructured TiO2 coating, and did not alter the surface topography or the phase composition of the coating. The adhesion of the MG63 cells onto the Mn-incorporated TiO2 coating was significantly enhanced compared with that on the Mn-free TiO2 coating and the pure Ti plates. In addition, the enhanced cell adhesion on the Mn-TiO2 coatings may have been mediated by the binding of the integrin subunits, β1 and α1, and the subsequent signal transduction pathway, involving FAK and ERK2. The study indicated that the novel Mn-TiO2 coating has potential for orthopedic implant applications, and that further investigations are required.

show abstract

Section: Discussionmentioning

confidence: 99%

Integrin-mediated osteoblastic adhesion on a porous manganese-incorporated TiO2 coating prepared by plasma electrolytic oxidation

Zhang

Zhu

et al. 2013

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Webster et al [41] observed increase of vitronectin adsorption and subsequently preferable osteoblast adhesion on nanostructured surfaces compared to conventional surfaces. Several studies have shown that micro/nanostructured topography might be much compatible for good mimic of natural extracellular matrix [42,43]. Zhao et al [44] fabricated hybrid micro/nano-textured titanium surface by acid etching-anodization method and enhancements of multiple osteoblast functions compared to surface with microtopography, such as adhesion, proliferation, ALP activity were reported.…”

Section: Discussionmentioning

confidence: 99%

Surface modification of titanium by hydrothermal treatment in Mg-containing solution and early osteoblast responses

Shi

Nakagawa

Kawachi

et al. 2012

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Surface modification on titanium was carried out in order to improve its bioactivity. Pure titanium was hydrothermally treated in distilled water and 0.1 M MgCl(2) solutions at 200°C for 24 h. Surface morphology, roughness, wettability and chemical composition were characterized before and after treatment. Bovine serum albumin was used as model to study protein adsorption. MC3T3-E1 cells were cultured and initial cell attachment, morphology, proliferation were evaluated. After hydrothermal treatment, nano-sized precipitations were observed and samples showed superhydrophilicity. Magnesium (Mg) was immobilized into titanium surface by hydrothermal treatment. Protein adsorption was significantly increased on Mg-containing samples. Cell attachment was improved and cell spreading was enhanced on Mg-containing samples compared with untreated or those treated in distilled water. Increased early cellular attachment on the MgTi surface resulted in subsequent increase of number of proliferated cells. Hydrothermal treatment in MgCl(2) solution was expected to be an effective method to fabricate titanium implant with good bioactivity.

show abstract

“…Researchers have used simple anodization to create nanoscale oxide layer on pure titanium surface to improve its corrosion resistance [11][12][13]. Moreover, the osseointegration of the titanium can be greatly increased by anodization processes [13][14][15]. However, no available reports exist on corrosion durability of the titaniumporcelain bonding strength after anodization.…”

Section: Please Scroll Down For Articlementioning

confidence: 99%

Effect of Anodization on Titanium-Porcelain Bonding

Guo

Tian

et al. 2013

Materials and Manufacturing Processes

View full text Add to dashboard Cite

The effects of anodization processes on titanium-porcelain bonding were investigated. The morphologies and phase structures were evaluated by field-emission scanning electron microscopy (F-SEM) and X-ray diffraction (XRD). The bonding strength was investigated by three-point flexure test. The corrosion resistance of titanium in artificial saliva was investigated. The SEM results showed that a titanium oxide film with submicron stripes and nano-pores could be prepared by anodization and HF acid pretreatment. This titanium oxide film increased chemical bonding and mechanical interlocking between titanium and porcelain. The anodization process also enhanced the corrosion resistance of the titanium, which led to the increase of corrosion durability of the Ti-porcelain bonding strength.

show abstract

Effect of nanotubular-micro-roughened titanium surface on cell response in vitro and osseointegration in vivo

Cited by 39 publications

References 12 publications

Integrin-mediated osteoblastic adhesion on a porous manganese-incorporated TiO2 coating prepared by plasma electrolytic oxidation

Integrin-mediated osteoblastic adhesion on a porous manganese-incorporated TiO2 coating prepared by plasma electrolytic oxidation

Surface modification of titanium by hydrothermal treatment in Mg-containing solution and early osteoblast responses

Effect of Anodization on Titanium-Porcelain Bonding

Contact Info

Product

Resources

About