Effect of Neuroleptics on immunoglobulins in Schizophrenia

Abstract

Fifty four schizophrenic patients, diagnosed a s per Research Diagnostic Criteria, were studied for the imn~unoglobulin profiles. The patients were given neuroleptics and the influence 01' neuroleptics on serum immunoglobulins IgG, IgA and IgM wds assessed by comparing the pretreatment and post-treatment immunoglobulin levels. A significant elevation of IgG levels was found in paranoid schizophrenics alter neurolptic treatment. IgA and IgM showed no alterarion The etiological implications are discussed.

QSAR studies on drugs acting at the central nervous system

“…Equation 116was log (1/C) = 1.850* -0.945*2 -7.90EHomo + 5.117 (116) n = 6, r = 0.975 log (1/C) = 1.200*r + 1.633*x + 0.543 (117) n = 16, r = 0.926, s = 0.615 log (1/C) = 1.213*r + 1.205*x + 0.861 (118) n = 16, r = 0.926, s = 0.598 derived for the mouse writhing assay of imidazolines,159 and eq 117 and 118 were obtained for mouse tail flick and writhing assays, respectively, of the derivatives of XXXVI. 160 In eq 116, there is, however, one additional term, EHOmo> which denotes the energy of the highest occupied molecular orbital in a quantum mechanical treatment of a 7r-electron system. The involvement of this term refers to a charge-transfer phenomenon taking place in a drug-receptor interaction.…”