Effect of Nigella Sativa seed and Thymoquinone on Reproductive Parameters in Sterptozotocine Induced Diabetic and Normal Male Albino Rats

Aithal, Manjunath; Haseena, S; Das, Kusal K.; Saheb, Shaik Hussain

doi:10.16965/ijims.2016.109

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…These are also consistent with a previous study that TQ had significantly improved the plasma testosterone level and epididymal sperm count caused by administration of lead [32]. In addition, several reports have shown that TQ plays a role to increase Leydig cell number and testosterone levels which eventually improved spermatogenesis [33,34]. Thymoquinone also exerts marked antioxidant characteristic which could ameliorate the spermatogenesis impairment caused by testicular injury through oxidative stress.…”

Section: Discussionsupporting

confidence: 91%

Ameliorative Effects of Thymoquinone on Sperm Parameters and Testosterone Level of Nicotine-Treated Sprague Dawley Rats

Rosli

Hashim

Osman

et al. 2019

Braz. arch. biol. technol.

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Thymoquinone (TQ), the main constituent of the volatile oil derived from Nigella sativa has shown pharmacological benefits against various diseases while nicotine is an active component in cigarette that is known to be detrimental. This study was conducted to assess the ameliorating effects of TQ on sperm count, membrane, mitochondria and testosterone of nicotine-treated rats. Rats were randomized into four groups: control, nicotine, TQ, and nicotine with TQ. Nicotine (5 mg/kg bwt/day) was subcutaneously injected for 30 days to induce damaging effects on sperm and testosterone level. Rats were HIGHLIGHTS• Nicotine negatively affected sperm count, membrane, mitochondria and testosterone level.Rosli, F.D.; et al.

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Section: Discussionsupporting

confidence: 91%

Ameliorative Effects of Thymoquinone on Sperm Parameters and Testosterone Level of Nicotine-Treated Sprague Dawley Rats

Rosli

Hashim

Osman

et al. 2019

Braz. arch. biol. technol.

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“…TQ significantly attenuated cadmium-and lead-induced decreases in serum testosterone in rats (Fouad, Albuali, & Jresat, 2014) and (Mabrouk & Ben Cheikh, 2016).TQ ameliorated testicular tissue inflammation and restored the normal balance of sex hormones; testosterone, LH and FSH induced by sodium nitrite both in vivo and in vitro (Alyoussef & Al-Gayyar, 2016). Aithal et al(Aithal, Haseena, Das, & Saheb, 2016) also showed that TQ increased the serum testosterone levels in arsenic-induced and sterptozotocine-induced testicular toxicity in male rats. Capsaicin significantly increased the serum levels of testosterone, FSH and LH.…”

Section: Discussionmentioning

confidence: 84%

Effects of Thymoquinone or Capsaicin against Acrylamide-Induced Testicular Failure in Rats: Impact Oxidative Stress, NF-Κb/P65, and Occludin

Hasan¹,

haleem²,

Arafa³

2020

Preprint

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Endocrine disrupting effects have become a major issue in the field of environmental toxicology. Due to the testicular toxicity reported for acrylamide and confirmed in our study, and the double jeopardy with its well-documented carcinogenicity following leaching out from overcooked starchy foods, the current study was extended to address the possible protective effects of two nutraceuticals. The present study was designed to assess the possible reproductive toxicity of acrylamide in adult male Swiss albino rats. Also, the work was extended to investigate the potential protective effects of two nutraceuticals namely; thymoquinone (TQ) and capsaicin against acrylamide-induced reproductive toxicity. Sixty male albino rats were allotted into six groups. Group 1: Rats received free tap water and served as control group. Group 2: Rats received acrylamide in a daily dose and served as the model. Group 3: Rats were administered TQ twice weekly. Group 4: Rats were administered capsaicin once daily. Group 5: Rats challenged with acrylamide were administered TQ twice weekly. Group 6: Rats challenged with acrylamide were administered capsaicin once daily. A murine model of acrylamide testicular toxicity was reproduced and was characterized biochemically, morphologically and histologically. Acrylamide increased oxidative stress, expression of testicular NF-κB/p65, in addition down regulated the expression of occludin that may further account for its testicular toxicity. Both nutraceuticals; TQ and capsaicin have proven more or less efficacy in ameliorating all the toxic insults exerted by acrylamide in the current reproductive toxicity model.

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“…In addition, TQ administration significantly increased serum testosterone level and AR expression in the testis. This may be attributed to the preservation of Leydig cells through its antioxidant effect or its ability to enhance aromatase gene expression, which subsequently enhanced spermatogenesis ( Aithal et al, 2016 ; Negi et al, 2018 ). In the same line of these findings, TQ has been described to have fertility-enhancing effect ( Wani et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression

et al. 2022

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Background: Hypothyroidism has been linked to many testicular structural and dysfunctional changes in males. Thymoquinone (TQ) has shown a potent testicular protective effect through its antioxidant, anti-inflammatory, antiapoptotic, fertility-enhancing, and endocrine modulatory activities.Objectives: This study aimed to investigate the efficacy of TQ in preserving the testicular structure of a model of experimentally induced hypothyroidism in rats and identify the mechanism behind this effect.Materials and methods: Propylthiouracil (PTU) was used to induce hypothyroidism in adult male Wistar rats, who were then treated with TQ (50 mg/kg/body weight) for 4 weeks and compared to the untreated rats. Thyroid hormonal profile, oxidants/antioxidants profile, and serum testosterone levels were assessed. Gene expression and immune expression of SIRT1 and pro-inflammatory cytokines TNF-α and NF-κB were also assessed in the testicular tissue.Results: TQ administration successfully improved PTU-induced disturbance in the thyroid hormonal profile (T3, T4, and TSH), serum testosterone level, and pancreatic antioxidants compared to the untreated hypothyroid group. TQ significantly downregulated (p = 0.001, p ˂ 0.001) TNF-α and NF-κB transcription, while it significantly upregulated (p = 0.01) SIRT1 transcription in the testes of hypothyroid rats. TQ markedly relieved the histopathological testicular changes induced by PTU and significantly increased (p = 0.002, p = 0.01) the sectional area of seminiferous tubules and germinal epithelial height, respectively. TUNEL-positive apoptotic germinal cells were significantly decreased (p ˂ 0.001), while PCNA-positive proliferating germinal cells and androgen receptor expression were significantly increased (p ˂ 0.001) in the testes of TQ-treated hypothyroid rats.Conclusion: Thymoquinone could limit the hypothyroidism-induced structural changes in the testis, mostly through the upregulation of SIRT1 expression, which seems to mediate its promising antioxidant, anti-inflammatory and antiapoptotic effects that were evident in this study. Therefore, TQ is recommended as an adjuvant safe supplement in managing hypothyroidism, especially in males.

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Effect of Nigella Sativa seed and Thymoquinone on Reproductive Parameters in Sterptozotocine Induced Diabetic and Normal Male Albino Rats

Cited by 4 publications

References 11 publications

Ameliorative Effects of Thymoquinone on Sperm Parameters and Testosterone Level of Nicotine-Treated Sprague Dawley Rats

Ameliorative Effects of Thymoquinone on Sperm Parameters and Testosterone Level of Nicotine-Treated Sprague Dawley Rats

Effects of Thymoquinone or Capsaicin against Acrylamide-Induced Testicular Failure in Rats: Impact Oxidative Stress, NF-Κb/P65, and Occludin

Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression

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