Effect of nitric oxide on auditory cortical neurons of aged rats

Lee, Jong-Ju; Cho, Young-Wuk; Huh, Youngbuhm; Il, Chang

doi:10.1016/j.neulet.2008.09.074

Cited by 10 publications

(13 citation statements)

References 26 publications

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“…The exact nature of these changes is dependent upon the anatomic location and function of the inhibitory circuits within the particular primary sensory system. Previously, we showed that aging increased NO production in rat A1 neurons (Lee et al, 2008). In addition, the present study indicate that NO suppressed GABA neurotransmission in A1 neurons.…”

Section: Discussionsupporting

confidence: 70%

“…Although several different signaling pathways may be involved in NO-mediated prestsynaptic modulation, the NO/cGMP/PKG pathway and K ＋ channels seems critical to NO-induced presynaptic GABA release in the paraventricular nucleus of the hypothalamus (Li et al, 2004;Yang et al, 2007). In addition, postsynaptic voltage-gated K ＋ channels of rat auditory cortical neurons were activated by increased levels of NO (Lee et al, 2008). However, the present findings do not suggest a role for K ＋ channels in the presynaptic NO modulation of GABAergic sIPSCs (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Age-associated changes arise from the production of free-radicals, including the superoxide, hydroxyl anions, nitric oxide, and peroxynitrite (Knight, 1995;Peinado, 1998). As the amount of NO increases with age, NO can damage the central auditory nervous system, causing age-related hearing loss (Huh et al, 2008). Aging and partial damage to the peripheral sensory systems of mammals appear to result in plastic pre-and postsynaptic changes in the inhibitory neurotransmitter systems of the primary sensory pathways.…”

Section: Discussionmentioning

confidence: 99%

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Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

Lee

2009

Korean J Physiol Pharmacol

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The auditory cortex (A1) encodes the acquired significance of sound for the perception and interpretation of sound. Nitric oxide (NO) is a gas molecule with free radical properties that functions as a transmitter molecule and can alter neural activity without direct synaptic connections. W e used whole-cell recordings under voltage clamp to investigate the effect of NO on spontaneous GABAergic synaptic transmission in mechanically isolated rat auditory cortical neurons preserving functional presynaptic nerve terminals. GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) in the A1 were completely blocked by bicuculline. The NO donor, S-nitroso-N-acetylpenicillamine (SNAP), reduced the GABAergic sIPSC frequency without affecting the mean current amplitude. The SNAPinduced inhibition of sIPSC frequency was mimicked by 8-bromoguanosine cyclic 3',5'-monophosphate, a membrane permeable cyclic-GMP analogue, and blocked by 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, a specific NO scavenger. Blockade of presynaptic K ＋ channels by 4-aminopyridine, a K ＋ channel blocker, increased the frequencies of GABAergic sIPSCs, but did not affect the inhibitory effects of SNAP. However, blocking of presynaptic Ca 2＋ channels by Cd 2＋ , a general voltage-dependent Ca 2＋ channel blocker, decreased the frequencies of GABAergic sIPSCs, and blocked SNAP-induced reduction of sIPSC frequency. These findings suggest that NO inhibits spontaneous GABA release by activation of cGMP-dependent signaling and inhibition of presynaptic Ca 2＋ channels in the presynaptic nerve terminals of A1 neurons.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

Lee

2009

Korean J Physiol Pharmacol

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“…The rat brain was quickly removed and dehydrated in 30% sucrose (in 4% PFA), and the brain was sectioned at 18 μm and slices were dried at room temperature. Finally, cresyl violet staining was conducted according to a previously reported method (Lee et al, 2008; Figure 1C ).…”

Section: Methodsmentioning

confidence: 99%

Ventral tegmental area activation promotes firing precision and strength through circuit inhibition in the primary auditory cortex

Lou

Luo

Zhang

et al. 2014

Front. Neural Circuits

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The activation of the ventral tegmental area (VTA) can rebuild the tonotopic representation in the primary auditory cortex (A1), but the cellular mechanisms remain largely unknown. Here, we investigated the firing patterns and membrane potential dynamics of neurons in A1 under the influence of VTA activation using in vivo intracellular recording. We found that VTA activation can significantly reduce the variability of sound evoked responses and promote the firing precision and strength of A1 neurons. Furthermore, the compressed response window was caused by an early hyperpolarization as a result of enhanced circuit inhibition. Our study suggested a possible mechanism of how the reward system affects information processing in sensory cortex: VTA activation strengthens cortical inhibition, which shortens the response window of post-synaptic cortical neurons and further promotes the precision and strength of neuronal activity.

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“…Recently, we reported increased expression of neuronal-type nitric oxide synthase (nNOS) and 3-NT in auditory cortical neurons of aged rats (Lee et al 2008). Although the relationship between aging and NO is well studied, little is known regarding the effects of NO on the lateral geniculate nucleus (LGN).…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in nitric oxide synthase in the lateral geniculate nucleus of rats

Hwang

Huh

2010

J Mol Hist

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Age-related changes in nitric oxide production in the visual system have not been well characterized. Therefore, we used staining and image-processing approaches to describe changes in levels of neuronal nitric oxide synthase (nNOS), the NADPH-diaphorase (NADPH-d) histochemical marker, and 3-nitrotyrosine in the lateral geniculate nucleus (LGN) of young and aged rats. The LGN plays an important role in the visual system, as it acts as a visual relay nucleus. Quantitative analysis of NADPH-d-positive and nNOS-immunoreactive neurons revealed significant optical density increases in the dorsal LGN and ventral LGN of aged rats; however, no significant changes were observed in the number of neurons with age. 3-Nitrotyrosine immunoreactivity was increased in the dorsal LGN and ventral LGN of aged rats. These results indicate that increased nitric oxide production and peroxynitrite may be associated with alterations in visual function during aging.

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Effect of nitric oxide on auditory cortical neurons of aged rats

Cited by 10 publications

References 26 publications

Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

Ventral tegmental area activation promotes firing precision and strength through circuit inhibition in the primary auditory cortex

Age-related changes in nitric oxide synthase in the lateral geniculate nucleus of rats

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