Effect of obesity on the ovarian follicular environment and developmental competence of the oocyte

Andreas, E.; Winstanley, Yasmyn E.; Robker, Rebecca L.

doi:10.1016/j.coemr.2021.03.013

Cited by 8 publications

(11 citation statements)

References 46 publications

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“…The complex mechanisms regulating ovarian folliculogenesis reflect their susceptibility to maternal physiological suitability. Overweight mothers fed high-fat diets are an outstanding model of a biological condition in which the ovarian follicular environment may be compromised [ 53 ]. More in detail, uncontrolled fat intake may affect both germinal and somatic follicle compartments, with the incidence of obesity earlier in life constituting a further risk for subsequent oocyte development [ 3 ].…”

Section: High-fat Diet Affecting Ovarian Folliculogenesismentioning

confidence: 99%

“…Timely and finely regulated cleavage cellular events upon zygote formation dictate full completion of embryogenesis leading to live offspring. Any perturbations of these events determine embryo developmental defects, and literature studies concluded that the origin of these developmental problems could arise from compromised oocyte quality [ 53 , 230 ]. As mentioned above, metabolic fluctuations in the follicular environment are associated with deep changes in oocytes and their subsequent developmental competence in the blastocyst stage as shown in different mammal models (non-human primates: [ 86 ]; sheep: [ 118 ]; mice: [ 38 , 41 , 132 , 213 ]; humans: [ 79 ]; bovines: [ 182 ]; and rabbits: [ 18 ]).…”

Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 99%

“…Recently, and in agreement, a prospective study conducted on 240 infertile women showed that high dietary fat consumption was adversely related to embryonic development [ 236 ]. Moreover, recent studies are now elucidating that the impaired embryo developmental competence could be due to three main oocyte-related effects: (1) lipotoxicity, (2) mitochondrial dysfunction, and (3) epigenetic dysregulation [ 53 ].…”

Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 99%

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High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

et al. 2022

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Female reproduction focuses mainly on achieving fully grown follicles and competent oocytes to be successfully fertilized, as well as on nourishing the developing offspring once pregnancy occurs. Current evidence demonstrates that obesity and/or high-fat diet regimes can perturbate these processes, leading to female infertility and transgenerational disorders. Since the mechanisms and reproductive processes involved are not yet fully clarified, the present review is designed as a systematic and comparative survey of the available literature. The available data demonstrate the adverse influences of obesity on diverse reproductive processes, such as folliculogenesis, oogenesis, and embryo development/implant. The negative reproductive impact may be attributed to a direct action on reproductive somatic and germinal compartments and/or to an indirect influence mediated by the endocrine, metabolic, and immune axis control systems. Overall, the present review highlights the fragmentation of the current information limiting the comprehension of the reproductive impact of a high-fat diet. Based on the incidence and prevalence of obesity in the Western countries, this topic becomes a research challenge to increase self-awareness of dietary reproductive risk to propose solid and rigorous preventive dietary regimes, as well as to develop targeted pharmacological interventions.

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Section: High-fat Diet Affecting Ovarian Folliculogenesismentioning

confidence: 99%

Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 99%

Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 99%

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High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

et al. 2022

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“…Obese women have decreased fertility, with decreased numbers and quality of oocytes and embryos. Although the biology and mechanisms are still poorly understood, there is rising evidence that metabolic disturbances in obese women affect reproductive functions [ 1 , 2 , 43 , 44 ]. Among the metabolites found in follicular fluid and closely affecting follicular and oocyte development, free fatty acids were identified as key molecules contributing to the obesity-associated impaired oocyte developmental competence and metabolism [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The increasing prevalence of metabolic syndrome worldwide and its association with adverse health effects, including impaired reproductive function in women, have become issues of concern over the past decade. Maternal metabolic disorders such as obesity and diabetes are detrimental factors that compromise fertility and the success rates of medically assisted procreation (MAP) procedures [ 1 , 2 ]. Accumulating evidence in several animal studies, especially the negative energy balance (NEB) model in bovine, contributed to indicate that free fatty acids (FFA) are key molecules associated with impaired cumulus-oocyte-complex (COC) morphology and impaired oocyte developmental competence and metabolism [ 3 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin

2021

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Maternal metabolic disorders such as obesity and diabetes are detrimental factors that compromise fertility and the success rates of medically assisted procreation procedures. During metabolic stress, adipose tissue is more likely to release free fatty acids (FFA) in the serum resulting in an increase of FFA levels not only in blood, but also in follicular fluid (FF). In humans, high concentrations of palmitic acid and stearic acid reduced granulosa cell survival and were associated with poor cumulus-oocyte complex (COC) morphology. Obesity and high levels of circulating FFA were also causatively linked to hampered insulin sensitivity in cells and compensatory hyperinsulinemia. To provide a global picture of the principal upstream signaling pathways and genomic mechanisms involved in this metabolic context, human granulosa-like tumor cells (KGN) were treated with a combination of palmitic acid, oleic acid, and stearic acid at the higher physiological concentrations found in the follicular fluid of women with a higher body mass index (BMI) (≥ 30.0 kg/m2). We also tested a high concentration of insulin alone and in combination with high concentrations of fatty acids. Transcription analysis by RNA-seq with a cut off for fold change of 1.5 and p-value 0.05 resulted in thousands of differentially expressed genes for each treatment. Using analysis software such as Ingenuity Pathway Analysis (IPA), we were able to establish that high concentrations of FFA affected the expression of genes mainly related to glucose and insulin homoeostasis, fatty acid metabolism, as well as steroidogenesis and granulosa cell differentiation processes. The combination of insulin and high concentrations of FFA affected signaling pathways related to apoptosis, inflammation, and oxidative stress. Taken together, our results provided new information on the mechanisms that might be involved in human granulosa cells exposed to high concentrations of FFA and insulin in the contexts of metabolism disorders.

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L-carnitine enhances developmental potential of bovine oocytes matured under high lipid concentrations in vitro

Catandi

Cheng

Chicco

et al. 2023

Animal Reproduction Science

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Effect of obesity on the ovarian follicular environment and developmental competence of the oocyte

Cited by 8 publications

References 46 publications

High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin

L-carnitine enhances developmental potential of bovine oocytes matured under high lipid concentrations in vitro

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