Effect of oil-based calcium hydroxide (Osteoinductal) on distraction osteogenesis in rabbit mandible

Polat, Hidayet Burak; Yeler, Hasan; Gümüş, Cesur; Bulut, Huseyin Eray; Küçük, Dervişhan

doi:10.1016/j.tripleo.2009.02.014

Cited by 8 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This oily calcium hydroxide containing paste (OCHS) (Osteora®, previously Osteoinductal®, DFS-Diamon GmbH Riedenburg, Germany) has been suggested to possess properties which may positively affect periodontal wound healing/regeneration [10-14]. It is based on calcium hydroxide (Ca(OH) 2 ) and uses a carrier substance consisting of synthetically produced porcine oleum pedum and vaselinum album.…”

Section: Introductionmentioning

confidence: 99%

“…Several animal studies which have evaluated the effects of OCHS on bone regeneration in various types of defects yielded different outcomes [10,11,20,21]. In a guided bone regeneration model using minipig calvaria, OCHS failed to exert osteoinductive properties and hampered bone healing when used in conjunction with guided bone regeneration [22].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the healing of endosseous implants was not improved when those were inserted together with OCHS [21]. On the other hand, application of OCHS during the osteotomy phase of distraction osteogenesis improved formation of new bone [10] while in experimentally created intrabony periodontal defects, the application of OCHS in conjunction with access flap surgery promoted periodontal regeneration [11]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro-activity of oily calcium hydroxide suspension on microorganisms as well as on human alveolar osteoblasts and periodontal ligament fibroblasts

et al. 2014

View full text Add to dashboard Cite

BackgroundFindings from animal and human studies have indicated that an oily calcium hydroxide suspension (OCHS) may improve early wound healing in the treatment of periodontitis. Calcium hydroxide as the main component is well known for its antimicrobial activity, however at present the effect of OCHS on the influence of periodontal wound healing/regeneration is still very limited. The purpose of this in vitro study was to investigate the effect of OCHS on periodontopathogenic bacteria as well as on the attachment and proliferation of osteoblasts and periodontal ligament fibroblasts.MethodsHuman alveolar osteoblasts (HAO) and periodontal ligament (PDL) fibroblasts were cultured on 3 concentrations of OCHS (2.5, 5 and 7.5 mg). Adhesion and proliferation were counted up to 48 h and mineralization was assayed after 1 and 2 weeks. Furthermore potential growth inhibitory activity on microorganisms associated with periodontal disease (e.g. Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans) as well as the influence of periodontopathogens and OCHS on the HAO and PDL fibroblasts counts were determined.ResultsMore than a 2-fold increase in adherent HAO cells was observed at 4 h following application of OCHS when compared to the control group (p = 0.007 for 2.5 mg). Proliferation of HAO cells at 48 h was stimulated by moderate concentrations (2.5 mg; 5 mg) of OCHS (each p < 0.001), whereas a high concentration (7.5 mg) of OCHS was inhibitory (p = 0.009). Mineralization was observed only for HAO cells treated with OCHS. OCHS did not exert any positive effect on attachment or proliferation of PDL fibroblasts. Although OCHS did not have an antibacterial effect, it did positively influence attachment and proliferation of HAO cells and PDL fibroblasts in the presence of periodontopathogens.ConclusionsThe present data suggests that OCHS promotes osteoblast attachment, proliferation and mineralization in a concentration-dependent manner and results are maintained in the presence of periodontal pathogens.

show abstract

Section: Introductionmentioning

confidence: 99%