Effect of omega-3 polyunsaturated fatty acid treatment over mechanical allodynia and depressive-like behavior associated with experimental diabetes

Redivo, Daiany Darlly Bello; Schreiber, Anne Karoline; Adami, Eliana Rezende; Ribeiro, Deidiane Elisa; Joca, Sâmia Regiane Lourenço; Zanoveli, Janaína Menezes; Cunha, Joice Maria da

doi:10.1016/j.bbr.2015.10.058

Cited by 36 publications

(18 citation statements)

References 67 publications

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“…In the CCI model, fluctuation in the time-dependency of depressive-like behaviours could also be explained by the inter-individual variability in pain induction that may be present in this model. Similarly, in a chemotherapy-induced neuropathy an early onset of depressive-like behaviour has been reported (Redivo et al, 2016;Toma et al, 2017). Regarding inflammatory pain models, increased immobility time in FST has been detected between 7 and 35 post-induction days in CFA injected animals (Borges et al, 2014;Hamann et al, 2016;Kim et al, 2012;Le, Lee, Su, Zou, & Wang, 2014;Maciel, Silva, Morrone, Calixto, & Campos, 2013;Urban et al, 2011;Zhang et al, 2016) and at four post-induction weeks in kaolin/carrageenan injected animals (Amorim et al, 2014).…”

Section: Forced Swim Testmentioning

confidence: 82%

How to study anxiety and depression in rodent models of chronic pain?

Kremer

Becker

Barrot

et al. 2020

Eur J of Neuroscience

110

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Section: Forced Swim Testmentioning

confidence: 82%

How to study anxiety and depression in rodent models of chronic pain?

Kremer

Becker

Barrot

et al. 2020

Eur J of Neuroscience

110

100

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“…Indeed, previous studies have reported analgesic properties of FO in thermal nociception and in mechanical allodynia associated with diabetic neuropathy ( Redivo et al, 2016 ). DHA alone has also shown anti-nociceptive effect attenuating inflammatory pain, NP, and painful diabetic neuropathy in rodents ( Lu et al, 2013 ; Manzhulo et al, 2015 ).…”

Section: Discussionmentioning

confidence: 97%

Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice

et al. 2017

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Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allodynia and hyperalgesia. We tested the preventive effect of an EPA/DHA-concentrate fish oil (CFO) on NP development and regenerative features. Swiss mice received daily oral treatment with CFO 4.6 or 2.3 g/kg for 10 days after NP was induced by partial sciatic nerve ligation. Mechanical allodynia and thermal hypernociception were assessed 5 days after injury. CFO 2.3 g/kg significantly prevented mechanical and thermal sensitization, reduced TNF levels in the spinal cord, sciatic MPO activity, and ATF-3 expression on DRG cells. CFO improved Sciatic Functional Index (SFI) as well as electrophysiological recordings, corroborating the increased GAP43 expression and total number of myelinated fibers observed in sciatic nerve. No locomotor activity impairment was observed in CFO treated groups. These results point to the regenerative and possibly protective properties of a combined EPA and DHA oral administration after peripheral nerve injury, as well as its anti-neuroinflammatory activity, evidencing ω-3 PUFAs promising therapeutic outcomes for NP treatment.

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“…Although aspirin, a classic NSAID, is not able to improve depressive-like behavior, like benzodiazepines and a cholecystokinin 2 (CCK2) antagonist, it decreases Inducible nitric oxide synthase (iNOS) and COX2 in the PFC in the formalin test and a social defeat model ( Rivat et al, 2010 ). Fatty acids with anti-inflammatory properties, such as omega-3, which increases BDNF in the hippocampus and PFC ( Redivo et al, 2016 ); palmatine, which decreases GFAP and purinergic receptor P2X7 expression in the hippocampus ( Shen et al, 2018 ); and b -caryophyllene, which suppresses the levels of SP and proinflammatory cytokines in the serum of diabetic animals ( Aguilar-Ávila et al, 2019 ), may be used to attenuate pain and depression. Additionally, like fluoxetine, triptolide decreases microglial activation in the hippocampus, but only triptolide or triptolide combined with fluoxetine decreases proinflammatory cytokines and increases IL-10 in the hippocampus after improving spinal nerve ligation-induced pain and depressive behavior ( Hu et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, different fatty acids have been studied in an attempt to attenuate pain and depression. Omega-3 improves anxiety and depression in people affected with chronic pain (Cortes et al, 2013), while omega-3, palmatine and β-caryophyllene attenuate pain and depression in a preclinical diabetic model (Redivo et al, 2016;Shen et al, 2018;Aguilar-Ávila et al, 2019). Berberine, a quaternary ammonium salt derived from a protoberberine group of alkaloids, is the principal bioactive compound found in Coptis chinensis, Berberis vulgaris and other medicinal plants that are effective in treating pain and depression (Tang et al, 2009;Ye et al, 2009).…”

Section: Understanding Treatments For Persistent Pain and Depressionmentioning

confidence: 99%

Neuroinflammation, Pain and Depression: An Overview of the Main Findings

et al. 2020

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Chronic pain is a serious public health problem with a strong affective-motivational component that makes it difficult to treat. Most patients with chronic pain suffer from severe depression; hence, both conditions coexist and exacerbate one another. Brain inflammatory mediators are critical for maintaining depression-pain syndrome and could be substrates for it. The goal of our paper was to review clinical and preclinical findings to identify the neuroinflammatory profile associated with the cooccurrence of pain and depression. In addition, we aimed to explore the regulatory effect of neuronal reorganization on the inflammatory response in pain and depression. We conducted a quantitative review supplemented by manual screening. Our results revealed inflammatory signatures in different preclinical models and clinical articles regarding depression-pain syndrome. We also identified that improvements in depressive symptoms and amelioration of pain can be modulated through direct targeting of inflammatory mediators, such as cytokines and molecular inhibitors of the inflammatory cascade. Additionally, therapeutic targets that improve and regulate the synaptic environment and its neurotransmitters may act as anti-inflammatory compounds, reducing local damage-associated molecular patterns and inhibiting the activation of immune and glial cells. Taken together, our data will help to better elucidate the neuroinflammatory profile in pain and depression and may help to identify pharmacological targets for effective management of depression-pain syndrome.

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Effect of omega-3 polyunsaturated fatty acid treatment over mechanical allodynia and depressive-like behavior associated with experimental diabetes

Cited by 36 publications

References 67 publications

How to study anxiety and depression in rodent models of chronic pain?

How to study anxiety and depression in rodent models of chronic pain?

Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice

Neuroinflammation, Pain and Depression: An Overview of the Main Findings

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