2008
DOI: 10.1111/j.1600-0781.2008.00385.x
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Effect of one session of ER:YAG laser ablation plus topical 5Fluorouracil on the outcome of short‐term NB‐UVB phototherapy in the treatment of non‐segmental vitiligo: a left–right comparative study

Abstract: We concluded that prior use of ER:YAG laser skin ablation, followed by 5FU application before NB-UVB phototherapy for vitiligo is a safe and tolerable technique that improves the outcome of short-term NB-UVB therapy and is expected to increase patient compliance.

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Cited by 78 publications
(97 citation statements)
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“…New treatment approaches such as using ablative lasers followed by topical application of 5-FU or steroids combined with NB-UVB phototherapy were studied and increased the repigmentation rate of vitiligo [9,10]. Despite their promising effects of the ablative lasers, ablation of the entire epidermis raises difficulties in the regulation of resurfacing depth and wound care, and involves a high risk of potential scars.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…New treatment approaches such as using ablative lasers followed by topical application of 5-FU or steroids combined with NB-UVB phototherapy were studied and increased the repigmentation rate of vitiligo [9,10]. Despite their promising effects of the ablative lasers, ablation of the entire epidermis raises difficulties in the regulation of resurfacing depth and wound care, and involves a high risk of potential scars.…”
Section: Discussionmentioning
confidence: 99%
“…The ablative lasers including carbon dioxide (CO 2 ) laser and erbium-YAG (Er:YAG) laser were considered superior to mechanical dermabrasion, owing to the controlled ablation [7,8]. The effects of CO 2 laser or Er:YAG laser ablation followed by topical application of 5-fluorouracil (5-FU) or hydrocortisone 17-butyrate cream combined with narrow band ultraviolet B (NB-UVB) phototherapy or not were, respectively, reported for treating nonsegmental vitiligo [9][10][11]. However, ablation of the entire epidermis frustrated the skin healing process.…”
mentioning
confidence: 99%
“…He-Ne lazer hem direkt etkisi hem de keratanositeleri tedavi etmesi ne bağlı olarak melanosit göçü önemli derecede artırarak etki gösterir 15 . Anbar ve ark., yaptıkları karşılaştırmalı bir çalışmada simetrik vitiligo lezyonlarından bir tarafa Er:YAG ablazyon ve 5 florourasil (5 FU) uygulaması sonrası darbant UVB tedavisi yapmışlar, diğer tarafa ise sadece darbant UVB tedavisi vermişler, çalışma sonucunda ise Er:YAG lazer ablazyon ve takibinde 5 FU uygulamasıyla yapılan tedavi kombinasyonun mono terapiye göre daha etkili olduğunu rapor etmişlerdir 16 .…”
Section: Vitiligounclassified
“…O vitiligo é uma doença crônica despigmentante que atinge a pele, com o surgimento de máculas brancas, ocasionadas pela perda funcional dos melanócitos da epiderme (1)(2)(3)(4)(5). Essa desordem pigmentar adquirida é comum em todas as raças, afetando pelo menos 1% do total da população antes dos 20 anos de idade (4,6).…”
Section: Introductionunclassified
“…Dentre os possíveis mecanismos que levam ao desaparecimento dos melanócitos funcionais, estão os imunomediados e os tóxicos como os mais prováveis (7). Evidências sugerem a ocorrência de um estresse oxidativo, levando à degeneração dos melanócitos (3,11,12). A estimulação dos melanócitos da epiderme, tanto as células recém-chegadas da bainha externa…”
Section: Introductionunclassified