Effect of Oocytes Quality and Ovarian Reserve on the Therapeutic Potential of in Vitro Fertilization in Patients of Late Reproductive Age

Крстич, Екатерина Викторовна; Крстич, М.; Юдаев, Виктор Николаевич

doi:10.18786/2072-0505-2014-31-70-75

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Согласно последним данным возрастной фак-тор влияет на снижение фертильности и миними-зирует вероятность успешного исхода в использо-вании программ ЭКО и ПЭ чаще ввиду ухудшения качества созревающих ооцитов, происходящего на фоне снижения овариального резерва [11].…”

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EFFECT OF THE AGE OF PATIENTS ON QUALITY OF OOCYTES, EMBRYOS AND OUTcomeS OF ASSISTED REPRODUCTIVE TECHNOLOGIES PROGRAMS

Kovalenko¹,

Malko²,

Ryazantsev³

et al. 2018

Kuban. nauсh. med. vestnik

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Aim. The aim of this study was to investigate the effect of the age of patients on the quantity and quality of their oocytes, quality of embryos and the results of in vitro fertilization and embryo transfer. Materials and methods. We conducted retrospective analysis of 668 embryo records of couples with women aged from 19 to 43, who were treated by in vitro fertilization and embryo transfer. In this analysis we included the data of the quantity and quality of their oocytes, their fertilization, methods of fertilization and the results of in vitro fertilization and embryo transfer. The efficiency of treatment was estimated by the pregnancy rate.

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Section: âведениеunclassified

EFFECT OF THE AGE OF PATIENTS ON QUALITY OF OOCYTES, EMBRYOS AND OUTcomeS OF ASSISTED REPRODUCTIVE TECHNOLOGIES PROGRAMS

Kovalenko¹,

Malko²,

Ryazantsev³

et al. 2018

Kuban. nauсh. med. vestnik

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Blood serum and follicular fluid relaxin: a pilot study of the hormone effects on ovarian function and fertilization efficiency

et al. 2020

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Hypothesis/aims of study. To date, one of the most important avenues of research in the field of reproductive medicine is the searching for new biochemical markers of oocyte quality and the prediction of the effectiveness of in vitro fertilization (IVF) protocols. The aim of this study was to assess the effect of relaxin levels in blood serum and follicular fluid on the efficiency of ovulation stimulation, fertilization, and characteristics of the embryos. Study design, materials and methods. This prospective randomized cohort study included 11 patients undergoing infertility treatment in a superovulation stimulation protocol using gonadotropin-releasing hormone antagonists. Age, body mass index, hormonal status, ovarian response, endometrial thickness and structure, the number and quality of oocytes and embryos, as well as fertilization efficiency were assessed. The level of relaxin in blood serum and follicular fluid samples was determined on the day of transvaginal follicle puncture using enzyme immunoassay. Results. A correlation between follicular fluid relaxin levels and body mass index, age, the number of oocytes, and their fertilization efficiency (p 0.05) was established. Changes in follicular fluid relaxin level were revealed depending on the gonadotropin preparations (p 0.05) and triggers of final maturation of oocytes (p 0.05). The tendency of the effect of gonadotropin doses on circulating relaxin levels, and of the hormone itself on endometrial thickness and the quality of oocytes was determined. Conclusion. Determination of the relaxin concentration can be considered as a promising method for predicting the result of ovarian stimulation and the efficiency of fertilization in IVF protocols.

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Effect of Oocytes Quality and Ovarian Reserve on the Therapeutic Potential of in Vitro Fertilization in Patients of Late Reproductive Age

Cited by 2 publications

References 25 publications

EFFECT OF THE AGE OF PATIENTS ON QUALITY OF OOCYTES, EMBRYOS AND OUTcomeS OF ASSISTED REPRODUCTIVE TECHNOLOGIES PROGRAMS

EFFECT OF THE AGE OF PATIENTS ON QUALITY OF OOCYTES, EMBRYOS AND OUTcomeS OF ASSISTED REPRODUCTIVE TECHNOLOGIES PROGRAMS

Blood serum and follicular fluid relaxin: a pilot study of the hormone effects on ovarian function and fertilization efficiency

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