Effect of oral administration of acetylsalicylic acid on haemostasis in the horse

Trujillo, Osvaldo; Rios, A; Maldonado, R.; Rudolph, W

doi:10.1111/j.2042-3306.1981.tb03491.x

Cited by 11 publications

(9 citation statements)

References 6 publications

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“…In addition, in the few studies available, data are often incomplete and very few horses were used in most of them. Data from Judson and Barton 9 and Trujillo et al 10 have been included in the table for completeness, but they cannot be compared with TBT values from other studies because of the different technique used in bleeding time determination.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, TBT has been used successfully in horses to detect the effects of ASA administration on hemostasis. Prolongations between 50% and more than 100% of the basal TBT value have been observed after ASA administration at different dosing regimes 8–12 …”

Section: Discussionmentioning

confidence: 99%

“…In horses, the technique has been standardized and has been used to test the influence of different drugs on platelet function inhibition 8 . Different studies have demonstrated that TBT is prolonged after ASA administration in horses, 8–12 although no changes in TBT have been observed after treatment with other drugs such as flunixin meglumine or phenylbutazone, 8 or after administration of unfractioned and low‐molecular‐weight heparins 13…”

mentioning

confidence: 99%

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Poor Reproducibility of Template Bleeding Time in Horses

Segura

Monreal

2008

Veterinary Internal Medicne

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Background: Template bleeding time (TBT) is considered to be a useful test for detecting platelet function disorders and the effect of platelet-activating drugs, but studies in human medicine have concluded that the test has poor reproducibility and sensitivity.Hypothesis: TBT has poor reproducibility in horses and has insufficient sensitivity to detect the effect of etamsylate on platelet function.Animals: Twenty healthy horses. Methods: TBT was determined and repeated 2 hours and 30 days later. TBT was also performed 2 hours after IV administration of etamsylate.Results: Although no statistical differences were seen between the TBT values obtained at different times, the coefficients of variation for TBT replicates ranged from 26.8% to 45.5%. The reference range for TBT was 138.4-860.4 seconds. No statistically significant shortening of the mean TBT value was observed after etamsylate administration.Conclusion and Clinical Importance: TBT has poor reproducibility, and the reference range is too wide to make TBT useful in a clinical setting. Other tests with higher reproducibility should be considered when assessing platelet function disorders in horses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Poor Reproducibility of Template Bleeding Time in Horses

Segura

Monreal

2008

Veterinary Internal Medicne

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“…Decreased formation of TXPq, a potent platelet proaggregatory agent, was thought to underlie these effects and the authors considered that this might provide the basis for a clinically useful antithrombotic action of NSAIDS in, for example, navicular disease. However, it has also been proposed as one possible cause of the epistaxis which frequently affects horses in training during or after exercise (Trujillo, Rios, Maldonado and Rudolph 1981). From control levels, platelet numbers were decreased and clotting, prothrombin and bleeding times were increased when Trujillo and his colleagues gave 6 or 12 g of aspirin orally to horses, daily for five days a week in alternate weeks.…”

Section: Other Nsaidsmentioning

confidence: 99%

Clinical pharmacology and therapeutic uses of non‐steroidal anti‐inflammatory drugs in the horse

Lees

Higgins

1985

Equine Veterinary Journal

143

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Summary Weak organic acids possessing anti‐inflammatory, analgesic and antipyretic properties — commonly known as aspirin‐like drugs — have been used in equine medicine for almost 100 years. These non‐steroidal anti‐inflammatory drugs (NSAIDs) may be classified chemically into two groups; the enolic acids such as phenylbutazone and carboxylic acids like flunixin, meclofenamate and naproxen. All NSAIDs have similar and possibly identical modes of action accounting for both their therapeutic and their toxic effects. They block some part of the cyclo‐oxygenase enzyme pathway and thereby suppress the synthesis of several chemical mediators of inflammation, collectively known as eicosanoids. The available evidence indicates that some of the newer NSAIDs have a reasonable safety margin but further studies are required. The toxicity of phenylbutazone in the horse has been investigated very thoroughly in recent years and it has been shown to cause renotoxicity and, most significantly, ulceration of the gastrointestinal tract when relatively high doses are administered. Several factors may predispose towards phenylbutazone toxicity in the horse, including breed and age, but high dosage is considered to be particularly important. The absorption into, and fate within, the body of NSAIDs are considered and particular attention is drawn to the ways in which these pharmacokinetic properties relate to the drugs' toxicity and clinical efficacy. In reviewing current knowledge of the clinical pharmacology of this important group of drugs, it is hoped to provide the clinician with a rational, scientific basis for their safe and effective use in equine practice.

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“…The standardisation of bleeding times has been achieved by the use of controlled venostasis and a template incision device (Ivy, Nelson and Bucher 1941 ;Meilke, Ramos and Britten 1973). Although a controlled standardised bleeding time test is lacking in equine practice, bleeding times in the horse have previously been reported (Judson and Barton 1981 ; Trujillo, Rios, Maldonado and Rudolph 1981).…”

Section: W Z Usamentioning

confidence: 99%