Effect of oral ginger on prevention of nausea and vomiting after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial

Bameshki, Alireza; Namaiee, Mohammad Hasan; Jangjoo, Ali; Dadgarmoghaddam, Maliheh; Ghalibaf, Mohammad Hosein Eshaghi; Ghorbanzadeh, Atefeh; Sheybani, Shima

doi:10.19082/6354

Cited by 18 publications

(30 citation statements)

References 33 publications

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“…The results of many studies are similar to those of our study ( 12 , 18 - 21 ), but a few studies reported contradictory results ( 22 - 24 ). As Montazeri et al showed, taking 1000 mg of ginger capsules one hour before surgery could not have any effect on nausea and vomiting at four and six hours after surgery ( 25 ).…”

Section: Discussionsupporting

confidence: 90%

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The Effect of Preoperative Zintoma Capsule on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Albooghobeish¹,

Ghomeishi

Adarvishi

et al. 2018

Anesth Pain Med

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BackgroundPostoperative nausea and vomiting (PONV), as one of the complications after laparoscopic cholecystectomy, occurs in over 40% - 77% of cases. Considering the numerous complications of synthetic drugs, there is a growing tendency towards the use of herbal medicines due to their unique features. Ginger root is one of the herbal compounds effective on nausea and vomiting.ObjectivesThe aim of this study was to evaluate the effect of preoperative Zintoma capsules on PONV after laparoscopic cholecystectomy.MethodsIn this quasi-experimental study, 130 eligible patients were randomly assigned to intervention (n = 65) and control (n = 65) groups using the four-block method. The intervention group received two capsules of 500 mg and one of 250 mg Zintoma. The control group received three placebo capsules. The severity of patients’ PONV was recorded at 0, 2, 6, 12, and 24 hours after surgery using a checklist and a standard VAS instrument. Data were analyzed using t-test, Chi-square test, and LSD Post Hoc test (ANOVA) in SPSS 19.ResultsThe severity of PONV and vomiting was significantly different between the two groups (P = 0.001) at the above time points. The mean severity of nausea (by VAS) changed in the intervention group from 7.92 ± 1.28 to 0.33 ± 0.67 and in the control group from 8.00 ± 1.20 to 2.11 ± 1.55. The postoperative vomiting was less frequent in the group receiving the Zintoma capsules. The postoperative use of chemical anti-vomiting and nausea drugs was significantly lower in the intervention group than in the placebo group (P = 0.001).ConclusionsZintoma capsules can be used as a supportive treatment in the prevention of nausea and vomiting by reducing the incidence rate of PONV.

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Section: Discussionsupporting

confidence: 90%

“…These opposite results can be attributed to single-woman samples in these studies or different types of laparoscopic surgery and the different anesthetic drugs or different doses of ginger capsules (500 mg, 750 mg, 1 g, 1.250 g, 1.5 g, and 2 g) ( 12 , 18 , 20 , 21 , 25 ).…”

Section: Discussionmentioning

confidence: 76%

The Effect of Preoperative Zintoma Capsule on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Albooghobeish¹,

Ghomeishi

Adarvishi

et al. 2018

Anesth Pain Med

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“…According to the results of the study, the frequency of vomiting after eye surgery was significantly lower in the ginger group than in the placebo group (P < 0.001). A study by Bameski et al indicated that the ginger extract may play a role in reducing the frequency of vomiting (27) and another study by Hajbaghery et al showed that ginger could reduce the frequency of vomiting in post-nephrectomy surgery, which coincide with the current study (28). Vousooghian et al demonstrated that ginger could decrease vomiting but was ineffective in the onset of PONV (29).…”

Section: Discussionsupporting

confidence: 87%

“…However, another study by Morin indicated that the ginger extract did not affect PONV in the first 24 hours post-surgery (30). It is very important to know that the ginger dose in Vosoghian et al study was 500 mg (29) and in Bameshki et al study, the frequency of vomiting was almost equal in both ginger and placebo groups with no significant difference (27). The ginger dose in the present study was 1000 mg while a meta-analysis study performed by Chaiyaknaprak et al in 2006 demonstrated that a minimum dose of 1 g prevented the PONV (23).…”

Section: Discussionmentioning

confidence: 99%

Dose Ginger Have Preventative Effects on PONV-Related Eye Surgery? A Clinical Trial

et al. 2019

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BackgroundPostoperative nausea and vomiting (PONV) is considered a common complication of anesthesia, which, particularly in eye surgery, may exert pressure on stitches and open or leak the surgical wound, leading to bleeding.ObjectivesWe aimed to study the effect of ginger on PONV and changes in vital signs after eye surgery.MethodsIn this triple-blind randomized controlled trial, 120 candidate patients for eye surgery were divided into group A (n = 40) and group B (n = 40). Patients in group A received the capsules of ginger 1 g while patients in group B received a placebo one hour before the procedure with 30 mL water. The incidence of nausea and the frequency of vomiting were evaluated at 0, 15, 30 minutes, and 2 hours after the operation. Also, the vital signs of the participants were recorded at certain times.ResultsThe results demonstrated a statistically significant difference in the frequency of nausea between group A and group B (P < 0.05). The severity of nausea was lower in group A than in group B immediately and 2 hours after recovery (P < 0.05). The incidence of vomiting was significantly lower in group A than in group B (P < 0.05). The vital signs were not significantly different between group A and group B (P > 0.05).ConclusionsGinger was effective in the prevention of PONV after eye surgery but had no impact on vital signs. Hence, ginger is proposed to use as a low-cost, prophylactic measure for PONV reduction.

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“…Ginger is safe and well tolerated, which appears to be useful in both pregnancy 283 – 285 and chemotherapy-induced PONV 286 , reducing the need for antiemetic rescue medications 287 – 297 . Ginger has also reduced PONV in patients undergoing cholecystectomy 287 – 289 , nephrectomy 282 , 291 , gynecologic/obstetric surgery 293 – 295 , ambulatory surgery 292 , cataract surgery 298 , and thyroidectomy 299 . However, there are also several studies that have reported contradictory results 300 – 302 .…”

Section: Perioperative Antiemetic Drugs Used For the Treatment And/ormentioning

confidence: 99%

Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review

et al. 2020

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Postoperative nausea and vomiting (PONV) and postdischarge nausea and vomiting (PDNV) remain common and distressing complications following surgery. The routine use of opioid analgesics for perioperative pain management is a major contributing factor to both PONV and PDNV after surgery. PONV and PDNV can delay discharge from the hospital or surgicenter, delay the return to normal activities of daily living after discharge home, and increase medical costs. The high incidence of PONV and PDNV has persisted despite the introduction of many new antiemetic drugs (and more aggressive use of antiemetic prophylaxis) over the last two decades as a result of growth in minimally invasive ambulatory surgery and the increased emphasis on earlier mobilization and discharge after both minor and major surgical procedures (e.g. enhanced recovery protocols). Pharmacologic management of PONV should be tailored to the patient’s risk level using the validated PONV and PDNV risk-scoring systems to encourage cost-effective practices and minimize the potential for adverse side effects due to drug interactions in the perioperative period. A combination of prophylactic antiemetic drugs with different mechanisms of action should be administered to patients with moderate to high risk of developing PONV. In addition to utilizing prophylactic antiemetic drugs, the management of perioperative pain using opioid-sparing multimodal analgesic techniques is critically important for achieving an enhanced recovery after surgery. In conclusion, the utilization of strategies to reduce the baseline risk of PONV (e.g. adequate hydration and the use of nonpharmacologic antiemetic and opioid-sparing analgesic techniques) and implementing multimodal antiemetic and analgesic regimens will reduce the likelihood of patients developing PONV and PDNV after surgery.

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Effect of oral ginger on prevention of nausea and vomiting after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial

Cited by 18 publications

References 33 publications

The Effect of Preoperative Zintoma Capsule on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

The Effect of Preoperative Zintoma Capsule on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Dose Ginger Have Preventative Effects on PONV-Related Eye Surgery? A Clinical Trial

Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review

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